Clinical, mycoIogical, histopathological and epidemiological studies were done on 26 cases of cutaneous sporotrichosis which were found during the last 5 years, from 1967 to 1971, at the out-patient clinic of department of dermatology of this hospital, and the results obtained were as follows: 1. Twenty two cases of ascending lympho-cutaneous sporotrichosis with nodules, abscesses and chancres, 2 cases of gummatous, and one of each verrucoid and impctiginous types were found in total 26 cases of the disease. 2. All the patients encountered were inhabitants in rural area, and most of them were farmers (21 cases: 81%)and children living in that area. The sources of the infection were considered as soil and plants contaminated with the causative organism. 3. Age distribution of the disease revealed highest incidence in the fourth and fifth decades (l8 cases: 69%), who were active workers in Korean farm.4. Analysis of primary focus and affected region of the body revealed highest involvement over the upper extremities (19 cases: 73%), especially right hand (9 cases: 35%) and right arm (3 cases: 12%). 5. Better culture results were obtained as following order: the best with culture material aspirated from the closed abscess with sterile needIe and syringe, the second: with embeding the tissue from the lesion in the media exposing about half, and the third: with the materials obtained from the chancre and gumrnatous lesiors. 6. Histopathological findings revealed frequently the chronic inflammatory granulomatous tissue reaction with polymorphic cellularity and occasionally some vascularity or small multiple focal necrosis in the lesions. 7. Differential diagnosis of the disease should be considered with Lepromatous leprosy, Cysticercosis cutis, Tuberculosis of the skin and other mycobacteriosis of the skin particularly in this country. 8. In Korea the rate of the incidences of the disease was found to be the highest in Chonnam province by comparing the result obtained from this study with those of the report by others. In Chonnam province the disease were distributed almost all the counties but there were some different rates of the incidence of the disease between each counties. 9. Frequency of the disease among the total number of out-patients (12. 208) was 0.2% or 1 to 500 and showed relatively high incidence of the disease in the farm workers in Chonnam province, Korea. Clinical, mycoIogical, histopathological and epidemiological studies were done on 26 cases of cutaneous sporotrichosis which were found during the last 5 years, from 1967 to 1971, at the out-patient clinic of department of dermatology of this hospital, and the results obtained were as follows: 1. Twenty two cases of ascending lympho-cutaneous sporotrichosis with nodules, abscesses and chancres, 2 cases of gummatous, and one of each verrucoid and impctiginous types were found in total 26 cases of the disease. 2. All the patients encountered were inhabitants in rural area, and most of them were farmers (21 cases: 81%)and children living in that area. The sources of the infection were considered as soil and plants contaminated with the causative organism. 3. Age distribution of the disease revealed highest incidence in the fourth and fifth decades (l8 cases: 69%), who were active workers in Korean farm.4. Analysis of primary focus and affected region of the body revealed highest involvement over the upper extremities (19 cases: 73%), especially right hand (9 cases: 35%) and right arm (3 cases: 12%). 5. Better culture results were obtained as following order: the best with culture material aspirated from the closed abscess with sterile needIe and syringe, the second: with embeding the tissue from the lesion in the media exposing about half, and the third: with the materials obtained from the chancre and gumrnatous lesiors. 6. Histopathological findings revealed frequently the chronic inflammatory granulomatous tissue reaction with polymorphic cellularity and occasionally some vascularity or small multiple focal necrosis in the lesions. 7. Differential diagnosis of the disease should be considered with Lepromatous leprosy, Cysticercosis cutis, Tuberculosis of the skin and other mycobacteriosis of the skin particularly in this country. 8. In Korea the rate of the incidences of the disease was found to be the highest in Chonnam province by comparing the result obtained from this study with those of the report by others. In Chonnam province the disease were distributed almost all the counties but there were some different rates of the incidence of the disease between each counties. 9. Frequency of the disease among the total number of out-patients (12. 208) was 0.2% or 1 to 500 and showed relatively high incidence of the disease in the farm workers in Chonnam province, Korea.
Abscess ; Age Distribution ; Arm ; Chancre ; Child ; Cysticercosis ; Dermatology ; Diagnosis, Differential ; Epidemiologic Studies* ; Fisheries* ; Hand ; Humans ; Incidence ; Jeollanam-do ; Korea* ; Leprosy, Lepromatous ; Necrosis ; Outpatients ; Skin ; Soil ; Sporotrichosis* ; Syringes ; Tuberculosis ; Upper Extremity

A case of nevus spilus, treated by, dermabrasion, was presented with discussion about the entity of the nevus. The patient, a 20 years old healthy woman, had had a palm-sized brown macule speckled with multiple darker small spots on the lateral aspect of her letf calf since birth. The pigmented macule was removed successfully by dermabrasion.
Dermabrasion* ; Female ; Humans ; Nevus* ; Parturition ; Young Adult

Intralesional injection of adrenal corticosteroids has widely teen used in the treatment of alopecia areata. But the concentration of the drug and the intrval of the injection are greatly different among the physicians practicing the method. The author evaluated the therapeutie results and untoward effects of the intralesional injetions using two different concentrations on the same lesion devided into two or on the two simultaneousely occurred lesions in each patient, to make exact comparsion of the different concentrations in total 24 patients. Intralesional injections with triamcinolone acetonide 5mg/m a 2 week interval showed appreciable hair regrowing in 4 weeks in 62.5% while 1mg/ml of the drug at equal interval showed appreciable hair regrowing in 6 weeks in 66.7%. But, in the group of 5mg/ml, 16.7% of the lesions showed considerable delay of the hair growing because of the atropy of the skin and hair follicle while no such delay was found in the group 1mg/ml. With the above data, tlie best result would be expected by th concentration between 1mg/ml and 5mg/ml in case of triarncinolone acetonide intralesional injection at 2 week intervals,
Adolescent ; Adrenal Cortex Hormones ; Alopecia Areata* ; Alopecia* ; Hair ; Hair Follicle ; Humans ; Injections, Intralesional ; Skin ; Triamcinolone Acetonide

BACKGROUND: Androgenetic alopecia (patterned baldness) occurs in both sexes showing different clinical features respectively. In men the hait thinning develops at about 20 years of age with a receding anterior hair line. In women it develops at about 30 years of age but the anterior hair liae is kept intact. Recently we have noticed female pattern baldness in young adult females in their early twenties. OBJECTIVE: The purpose of this study was to evaluate clinical and laboratory features of female patients with early onset patterned alopecia and to assess their therapeutic results. METHOD: Twenty-five cases of female pattern baldness who sought medical treatment for hair thinning before the age of 25 were examined for their clinical, laboratorial and treatment results. RESULTS: 1. 22.2 years was the average age at which the first medical care was sought and their onset of noticeable hair thinning was on average 18.3 years of age. 2. Aceording to Ludwigs classification, there were 76%(19 cases) with type I alopecia and 24%(6 cases) wit type II. Type III was not found. 3. A family history of patterned alopecia was seen in 56% of the first degree relatives. 4. Associated diseases were as follows: Seborrheic dermatitis(11 cases), hirsutism(9 cases), acne vulgaris(5 cases), menstrual irregularity(5 cases) and one case of each of polycystic ovarian disease, diabetes melitus and pulmonary tuberculosis. 5. Mild to moderate hirsutism was seen in 9(36%) cases in various anatomical locations. The most frequent location was in the linea alba area (6 cases), which was followed by the extremities and upper lip. 6. Serum iron and femtin levels were lower than the normal range in 10 cases(40%) and in 15 cases(60%) respectively, though hemoglobin levels were all normal. 7. Serum total testosterone and dehydroepiandrosterone sulfate(DHEAS) levels were increased in 52.1% and 52% patients respectively, compared to the normal range in Korean women. 8. In 12 cases who could be followed up for longer than 3 months, 11(90.2%) cases showed improvement in their hair volume on medical treatment. CONCLUSION: Androgenetic alopecia of females can occur as early as in males. The clinical and laboratory findings of such early female androgenetic alopecia were reported in 25 cases alongside their therapeutic outcomes.
Acne Vulgaris ; Alopecia* ; Classification ; Dehydroepiandrosterone ; Extremities ; Female* ; Hair ; Hirsutism ; Humans ; Iron ; Lip ; Male ; Ovarian Diseases ; Reference Values ; Testosterone ; Tuberculosis, Pulmonary ; Young Adult

No abstract available.

LSA of the glans and prepuce of the penis is uncommon. It usually appears as whitish plaques and macules and can progress to orificial narrowing, phimosis and carcinorna. The case presented herein showed distinct papules and nodules on the glans and inner side of the prepuce instead of usual flattened patches. The patient, 24 years old man, was seen first seven months after his initial notice of the illness and has been observed by the authors four years thereafter. For the first year the papuloncdules on the glans were hard in consistence and the glans itself was being contracting, From the third year, the hard papulonodules began to resolve but resulted in greatly contracted glans penis. To observe the diagncsic histopathological finding repeated biopsies were needed.
Biopsy ; Female ; Humans ; Lichen Sclerosus et Atrophicus* ; Lichens* ; Male ; Penis* ; Phimosis ; Young Adult

No abstract available.
Hair* ; Iron* ; Scalp*

The linear IgA bullous dermatosis is a rare chronic vesicobullous disease resembling dermatitis herpetiformis or bullous pemphigoid. We report a case of linear IgA bullous dermatosis developed in a 16 year old female, whose cutaneous lesions were unusually acute. The urticarial wheals started on her buttock and spread to her entire body in two hours and generalized blistering de veloped within four days, The response by dapsone was also dramatic. Routine histological and both direct and indirect immunofluorescent microscopic findings were typical of linear IgA bullous dermatosis.
Adolescent ; Adult* ; Blister ; Buttocks ; Dapsone ; Dermatitis Herpetiformis ; Female ; Humans ; Linear IgA Bullous Dermatosis* ; Pemphigoid, Bullous

BACKGROUND: Extensive involvernent of alopecia areata seems to be different from the usual common type of alopecia areata in its damage to the patient and its pragnosis. The two forms are best dealt with differently. OBJECTIVE: We performed a clinical observation of a severe form of alopecia areata to understand to its course and therapeuic respones. METHODS: Clinical analysis of 68 cases of severe alopecia areata (37 alopecia totalis, 6 alopecia subtotalis, 13 alopecia universalis, 11 alopecia subtotal universalis, 1 ophiasis) was done for 9 years from 1985 to 1994. RESULTS: 1. The sex distribution was equal. The developrnent of hair loss started before the age of 30 in 67.6%(46/68). Twenty two patients(32.4%) developed the alopecia during the early twenties. The overall mean age was 26.4 years. 2. The duration from the initial hair loss to the involvement of the whole scalp was less than 3 months in 80%(40/50~) of patierits showing whole scalp baldness. 3. Exclamation mark hairs were seen in 85% (57/67) of severe alopecia areata. In 5 patients who were examined just at the start of the hair loss, exclamation mark hairs were found several weeks later. 4. When treated by methyl prednisolone pulse therapy, duration of the disease and type of involvement are the most important prognastic factors as follows. a) 71%(32/45) of patients with less than 6 months duration showed satisfyingly good results cosmetically, but this figure dropped to 30.4% (7/23) in patients with longer than 6 months duration. b) 83.7% (36/43) of patients with alopecia totalis or subtotalis showed good results but this figure dropped to 12%(3/25) in patients with alopecia universalis, subtotal universalis or ophiasis. 5. Methyl prednisolone pulse therapy seemed to be recommended in the acute stage of extensive involvement of alopecia areata. CONCLUSION: Severe alopecia areata has predilection for young adults and seems to show extensive involvement frorn its early stage. Exclamation mark hairs need some time to appear even in their early active stage of hair hedding. Pulse methyl prednisolone therapy is thought to be recommended when the disease is in its early active stage.
Alopecia Areata* ; Alopecia* ; Hair ; Humans ; Prednisolone* ; Scalp ; Sex Distribution ; Young Adult

BACKGROUND: Extensive involvernent of alopecia areata seems to be different from the usual common type of alopecia areata in its damage to the patient and its pragnosis. The two forms are best dealt with differently. OBJECTIVE: We performed a clinical observation of a severe form of alopecia areata to understand to its course and therapeuic respones. METHODS: Clinical analysis of 68 cases of severe alopecia areata (37 alopecia totalis, 6 alopecia subtotalis, 13 alopecia universalis, 11 alopecia subtotal universalis, 1 ophiasis) was done for 9 years from 1985 to 1994. RESULTS: 1. The sex distribution was equal. The developrnent of hair loss started before the age of 30 in 67.6%(46/68). Twenty two patients(32.4%) developed the alopecia during the early twenties. The overall mean age was 26.4 years. 2. The duration from the initial hair loss to the involvement of the whole scalp was less than 3 months in 80%(40/50~) of patierits showing whole scalp baldness. 3. Exclamation mark hairs were seen in 85% (57/67) of severe alopecia areata. In 5 patients who were examined just at the start of the hair loss, exclamation mark hairs were found several weeks later. 4. When treated by methyl prednisolone pulse therapy, duration of the disease and type of involvement are the most important prognastic factors as follows. a) 71%(32/45) of patients with less than 6 months duration showed satisfyingly good results cosmetically, but this figure dropped to 30.4% (7/23) in patients with longer than 6 months duration. b) 83.7% (36/43) of patients with alopecia totalis or subtotalis showed good results but this figure dropped to 12%(3/25) in patients with alopecia universalis, subtotal universalis or ophiasis. 5. Methyl prednisolone pulse therapy seemed to be recommended in the acute stage of extensive involvement of alopecia areata. CONCLUSION: Severe alopecia areata has predilection for young adults and seems to show extensive involvement frorn its early stage. Exclamation mark hairs need some time to appear even in their early active stage of hair hedding. Pulse methyl prednisolone therapy is thought to be recommended when the disease is in its early active stage.
Alopecia Areata* ; Alopecia* ; Hair ; Humans ; Prednisolone* ; Scalp ; Sex Distribution ; Young Adult