1.The Effect of Cytochrome C in Ophthalmic Diseases.
Hee Chul KIM ; Jung Ja KIM ; Byong Gook PAK
Journal of the Korean Ophthalmological Society 1968;9(1):1-8
Cytochrome compounds which act as electron transfer agents in oxidation-reduction reactions. An important example is cytochrome c, which has a molecular weight of about 13,000 and contains one atom of iron per mol. Our attempt is to evaluate clinically the therapeutic effect of cytochrome c on the healing wound of the lesions which supposed to be oxygen concentration is lowered than in normal tissues in tissue respiration, and it used in neuropathy, muscle paralysis, retinopathy, vitreous hemorrhage, corneal chemical burns in ophthalmology. The patients included in the following series: They were five cases of retrobulbar optic neuritis, two cases of optic neuritis, one case of axial optic atrophy, two cases of simple optic atrophy, two cases of muscle paralysis, one case of central retinopathy, one case of chorio-retinal atrophy, one case of maculra degeneration, one case of diabetic retinopathy, one case of pigmentary degeneration of the retina, one case of vitreous hemorrhage, four cases of corneal chemical burn, and one case of corneal dystrophy. After intra-dermal injection with cytochrome c, evaluated the allergic character and it was given intra-venous injection. The results were as follows: 1) In total 23 cases, had excellent therapeutic effects on neuropathy, muscle paralysis, and corneal chemical burns. 2) In general, we found that it did not respond to central retinopathy and diabetic retinopathy. 3) We experienced that it have response to the old lesions. 4) It was interested that the night blindness could be disappeared by cytochrome c use in pigmentary degeneration of the retina. Yet there remain certain problems so far unsolved.
Atrophy
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Burns, Chemical
;
Cytochromes c*
;
Cytochromes*
;
Diabetic Retinopathy
;
Humans
;
Iron
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Molecular Weight
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Night Blindness
;
Ophthalmology
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Optic Atrophy
;
Optic Neuritis
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Oxidation-Reduction
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Oxygen
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Paralysis
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Respiration
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Retina
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Vitreous Hemorrhage
;
Wounds and Injuries
2.Clinical analysis of the inhalation injury of the facial burn patients.
Yark Sung JUNG ; Song KIM ; Hee Chul PARK
Journal of the Korean Surgical Society 1991;40(3):391-396
No abstract available.
Burns*
;
Humans
;
Inhalation*
4.A study on the rapid development of ciprofloxacin resistane in methicillin-resistant staphylococcus aureus.
Chul Weon CHOI ; Hee Jin JUNG ; Heung Jung WOO ; Sei Yong KANG ; Woo Joo KIM ; Seung Chul PARK
Korean Journal of Medicine 1993;45(1):92-98
No abstract available.
Ciprofloxacin*
;
Methicillin Resistance*
;
Methicillin-Resistant Staphylococcus aureus*
5.Role of Growth Factors and Cytokines on Bleomycin Induced Pulmonary Fibrosis.
Yong Hee LEE ; Soon Hee JUNG ; Chul Min AHN ; Sung Kyu KIM ; Sang Ho CHO
Tuberculosis and Respiratory Diseases 1997;44(4):871-888
BACKGROUND: It is now thought that the earliest manifestation of idiopathic pulmonary fibrosis is alveolitis, that is, an accumulation of inflammatory and immune effector cells within alveolar walls and spaces. Inflammatory cells including alveolar macrophages and resident normal pulmonary tissue cells participate through the release of many variable mediators such as inflammatory growth factors and cytokines, which contribute to tissue damage and finally cause chronic pulmonary inflammation and fibrosis. This study was performed to investigate the source and distribution pattern of transforming growth factor-beta1(TGF-beta1), platelet derived growth factor(PDGF), basic fibroblast growth factor(bFGF), interleukin 1(IL-1), interleukin 6(IL-6), tumor necrosis factor-alpha(TNF-alpha) and the role of these mediators on bleomycin(BLM)-induced pulmonary injury and fibrosis in rats. METHOD: Wistar rats were divided into three groups(control group, BML treated group, BML and vitamine E treated group). Animals were sacrifices periodically at 1, 2, 3, 4, 5, 7, 14, 21, 28 days after saline or BLM administration. The effects were compared to the results of bronchoalveolar lavage fluid analysis, light microscopic findings, immunohistochemical stains for six defferent mediators(TGF-beta1, PDGF, bFGF, IL-1, IL-6 and TNF-alpha) and mRNA in situ hybridization for TGF-beta1. RESULTS: IL-1 and IL-6 are maximally expressed at postbleomycin 1~7th day which are mainly produced by neutrophils and bronchiolar epithelium. It is thought that they induce recruitment of inflammatory cells at the injury site. The expression of IL-1 and IL-6 at the bronchiolar epithelium within 7th day is an indirect evidence of contribution of bronchiolar epithelial cells to promote and maintain the inflammatory and immune responses adjacent to the airways. TNF-alpha is mainly produced by neutrophils and bronchiolar epithelial cells during 1~5th day, alveolar macrophages during 7~28th day. At the earlier period, TNF-alpha causes recruitment of inflammatory cells at the injury site and later stimulates pulmonary fibrosis. The main secreting cells of TGF-beta1 are alveolar macrophages and bronchiolar epithelium and the target is pulmonary fibroblasts and extracellular matrix. TGF-beta1 and PDGF stimulate proliferation of pulmonary fibroblasts and TGF-beta1 and bFGF incite the fibroblasts to produce extracellular matrix. The vitamine E and BLM treated group shows few positive cells(p<0.05). CONCLUSION: After endothelial and epithelial injury, the neutrophils and bronchiolar epithelium secrete IL-1, IL-6, TNF-alpha which induce infiltration of many neutrophils. It is thought that variable enzymes and O2 radicals released by these neutrophils cause destruction of normal lung architecture and progression of pulmonary fibrosis. At the 7~28th day, TGF-beta1, PDGF, bFGF, TNF-alpha secreted by alveolar macrophages sting pulmonary fibroblasts into proliferating with increased production of extracellular matrix and finally, they make progression of pulmonary fibrosis. TNF-alpha compares quite important with TGF-beta1 to cause pulmonary fibrosis. Vitamine E seems to decrease the extent of BLM induced pulmonary fibrosis.
Animals
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Bites and Stings
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Bleomycin*
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Blood Platelets
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Bronchoalveolar Lavage Fluid
;
Coloring Agents
;
Cytokines*
;
Epithelial Cells
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Epithelium
;
Extracellular Matrix
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Fibroblasts
;
Fibrosis
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Idiopathic Pulmonary Fibrosis
;
In Situ Hybridization
;
Intercellular Signaling Peptides and Proteins*
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Interleukin-1
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Interleukin-6
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Interleukins
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Lung
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Lung Injury
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Macrophages, Alveolar
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Necrosis
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Neutrophils
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Pneumonia
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Pulmonary Fibrosis*
;
Rats
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Rats, Wistar
;
RNA, Messenger
;
Transforming Growth Factor beta
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Transforming Growth Factor beta1
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Tumor Necrosis Factor-alpha
;
Vitamins
6.Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus
Dughyun CHOI ; Bo-Yeon KIM ; Chan-Hee JUNG ; Chul-Hee KIM ; Ji-Oh MOK
Diabetes & Metabolism Journal 2021;45(3):358-367
It is known that the painful sensation of diabetic peripheral neuropathy (DPN) results in sleep problems in type 2 diabetes mellitus (T2DM). However, it is not known that the painless DPN also is associated with poor sleep quality in T2DM. The purpose of the current study was to investigate the association between painless DPN and poor sleep quality in T2DM. A total of 146 patients of T2DM who do not have any painful symptoms of DPN were recruited into the study. Among the patients, painless DPN was diagnosed by using the current perception threshold test. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire. The percentage of painless DPN was significantly higher in the poor sleep quality group than the good sleep quality group (70.0% vs. 35.5%, The current study showed that painless DPN was associated with poor sleep quality. Future studies are required to clarify the pathophysiologic causal relationship between painless DPN and sleep quality.
7.Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus
Dughyun CHOI ; Bo-Yeon KIM ; Chan-Hee JUNG ; Chul-Hee KIM ; Ji-Oh MOK
Diabetes & Metabolism Journal 2021;45(3):358-367
It is known that the painful sensation of diabetic peripheral neuropathy (DPN) results in sleep problems in type 2 diabetes mellitus (T2DM). However, it is not known that the painless DPN also is associated with poor sleep quality in T2DM. The purpose of the current study was to investigate the association between painless DPN and poor sleep quality in T2DM. A total of 146 patients of T2DM who do not have any painful symptoms of DPN were recruited into the study. Among the patients, painless DPN was diagnosed by using the current perception threshold test. Sleep quality was assessed using the Pittsburgh Sleep Quality Index questionnaire. The percentage of painless DPN was significantly higher in the poor sleep quality group than the good sleep quality group (70.0% vs. 35.5%, The current study showed that painless DPN was associated with poor sleep quality. Future studies are required to clarify the pathophysiologic causal relationship between painless DPN and sleep quality.
8.Effects of Phospholipase A2 Inhibitor, Ochnaflavone, on the TNF-alpha and NO Production in Macrophages.
Jung Hee KIM ; Chul JIN ; Jung Gil HONG ; Pan Gil SEO ; Suk Hwan BAEK
Korean Journal of Immunology 2000;22(3):157-163
No abstract available.
Macrophages*
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Phospholipases A2*
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Phospholipases*
;
Tumor Necrosis Factor-alpha*
9.A Comparative Analysis of Cervical Pap Smears Prepared by Conventional and ThinPrep Method.
Yeon Hwa LA ; Gyung Chul JO ; Sung Tae HAN ; Suk Hee JUNG ; Jung Rae SEO ; Woo Chul JUNG ; Sung Won LEE ; Yong JO ; Eui Sun RO
Korean Journal of Obstetrics and Gynecology 2000;43(8):1450-1458
No abstract available.
10.Knowledge of hepatitis B and follow-up test in HBs Ag positive patients.
Jee Hye HAN ; Duk Chul LEE ; Hye Ree LEE ; Hee Won PARK ; Gyu Chul JUNG ; Shin Gyu PARK
Journal of the Korean Academy of Family Medicine 1997;18(7):706-713
BACKGROUND: HBsAg carriers are 6-12% of population in Korea. The patients knowledge on hepatitis B and regular follow-up tests are important, because HBsAg carriers have infectivity and the disease may progress without symptoms. We surveyed their knowledge on the hepatitis B and the frequency of follow-up blood test and sonogram. METHODS: From March 1993 through September 1994, 630 patients who were diagnosed as HBsAg positive and Anti-HBs negative in a health promotion center of college hospital were surveyed by mailing questionnaire. The questionnaire included the result of HBV viral marker test, transmission routes, complications, and prevention methods of Hepatitis B, frequency of follow-up test, and doctors recommendation. RESULTS: Of the 490 questionnaires excluded the 140 questionaires returned due to wrong address, 100 were answered, making the reply rate 20.4%. As for the result of HBV marker test, 64% answered their HBV marker as HBsAg positve, 10% answered HBsAg negative, and 26% answered I dont know. 65% answered that they are HBV carrier. As for the mode of transmission, 59% answered that HBV is transmitted by blood, 57% from carrier mother at birth, 29 % by sexual intercourse. 76% of responders know that vaccination is needed for preventing vertical transmission. When making score on their knowledge, significant differences were showed according to education, income and doctors recommendation about regular follow-up test. The number of persons who took regular blood test every 6 to 12 months were 56(56%), and the number of persons who took regular abdominal ultrasonogram were 39(39%). The number of patients who were recommended regular follow-up by doctor was 76%. In this group, 51 persons(67.0%) took regular blood test and 35 persons(35%) took regular sonogram so this frequency is significantly higher than the other group(each 20.8%, 16.7%). CONCLUSIONS: The knowledge on hepatitis B in HBsAg positive patients is relatively low and the frequency of regular follow-up test is significantly higher in the group who took doctors recommendation. So it is very important that HBsAg carriers must be educated about the infectivity, preventive methods, and regular follow-up for early detection of complication like hepatocellular cancer.
Biomarkers
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Coitus
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Education
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Follow-Up Studies*
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Health Promotion
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Hematologic Tests
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Hepatitis B Surface Antigens
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Hepatitis B*
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Hepatitis*
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Humans
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Korea
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Liver Neoplasms
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Mothers
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Parturition
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Postal Service
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Ultrasonography
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Vaccination
;
Surveys and Questionnaires