We report a case of fibrous hamartoma of infancy in a 7-month-old male infant, in which a solitary, asymptomatic, walnut-sized, nomal skin-colored plaque occurred on the left middle back for about one month. Histopathologic findings showed the distinctive features of fibrous hamartoma of infancy, ie, trabeculae of dense collagenous tissue, whorls of immature spindle cells within a mucoid matrix, and interspersed mature adipose tissue, in the lower dermis. The lesion was excised without recurrence.
Adipose Tissue ; Collagen ; Dermis ; Hamartoma* ; Humans ; Infant ; Male ; Recurrence

We herein report a case of keratoderma showing the combined clinical manifestations of striate and marginal keratoderma. The patient was a 18-year-old giri who about a year ago noticed slightly yellowish, well-circurnscribed, hyperkeratotic plaques on the volar aspect of the fingers and palms of both hands in a linear pattern with bands of hyperkeratotic plaques at the edeges of the 2nd fingers. We also found hyperkeratotic plaques on the both soles which were confined to sites of pressure. She denied a history of any chronic pressure or trauma. There was no family member showing the same clinical features. The histopathological findings from the palm, volsr aspect of finger and a sole revealed marked hyperkeratosis, hypergranulosis, and acanthosis.
Adolescent ; Fingers ; Hand ; Humans

We describe a case of cutaneous chylous reflux, which is thought to be a kind of primary lymphedema, in a 19-year-old male who had suffered from multiple vesiculobullae and intermittent swelling on scrotum for about 6 years. Histopathologic findings showed multiple dilated lymphatic vascular channels in papillary dermis.
Dermis ; Humans ; Lymphedema ; Male ; Scrotum ; Young Adult

No abstract available.
Accidents, Traffic*

PURPOSE: To identify antitumor effect, indication and antitumor mechanism of p21/WAF1 gene therapy in human kidney and bladder cancer. MATERIALS AND METHODS: We cloned cDNA of wild type human p21 gene by reverse transcription-polymerase chain reaction(RT-PCR) technology and constructed a mammalian expression plasmid vector carrying cDNA of wild type human p21 and CMV enhancer/promotor(pCMV-p21). pCMV-p21 was administered in vitro in complex with HDL cationic polyliposome into human kidney cancer cells(CURC-1 and CURC-2), bladder cancer cells(RT4 and T24), and liver cancer cells(Hep3B and HepG2), followed by analysis of viable cell number, cellular morphology, cell cycle distribution and development of apoptosis. RESULTS: The expression of p21 was preserved in p53-wild type cells and markedly decreased or absent in p53-mutant cells. Administration of pCMV-p21:HDL complex induced high level expression of p21 and significant suppression of growth in all of the cancer cells examined, regardless of their genetic status of p21 and p53. Transfer of p21 to cancer cells induced not only decrease of proportion of cells in G2+M/S phase but also apoptosis. CONCLUSIONS: HDL cationic polyliposome-mediated p21 gene transfer may become a promising therapeutic modality for human kidney and bladder cancer and that p21 may have a novel function to induce apoptosis to human bladder and kidney cancer cells. Further studies are necessary on in vivo antitumor effect of p21 gene transfer and molecular mechanism of p21 gene-induced apoptosis.
Apoptosis ; Cell Count ; Cell Cycle ; Cell Line* ; Clone Cells ; DNA, Complementary ; Genetic Therapy ; Humans ; Kidney Neoplasms ; Kidney* ; Liver Neoplasms ; Plasmids ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Lymphomatous involvement of the gallbladder is rarely identified and manifests mostly as a local involvement of disseminated disease. There have been reported only about 20 primary malignant lymphomas of the gallbladder without involvement of other sites. A 63-year-old woman presented with jaundice, epigastric pain, and weight olss of two months duration. There was no systemic lymphadenopathy elsewhere. Abdominal computed tomograph revealed a focal thickening of the gallbladder wall. The removed gallbladder contained a well circumscribed, 5x3 cm-sized, slightly elevated firm area with accentuated mucosal papillary excrescences near the neck protion. The lesion involved whole thickness of the wall, and was made up of diffuse atypical lymphoid cell infiltrates of variable size accompanying plasmacytoid differentiation in areas. Some large tumor cells were pleomorphic and contained prominent nucleoli. To our knowledge, this is the first case of primary malignant lymphoma of the gallbladder in Korean literature.
Female ; Humans

No abstract available.
Humans ; Peritoneal Dialysis, Continuous Ambulatory* ; Peritonitis*

No abstract available.
Biopsy* ; Cytoplasm* ; Follow-Up Studies* ; Glomerulonephritis* ; Kidney Transplantation*

No abstract available.
Humans ; Renal Insufficiency, Chronic* ; Rhabdomyolysis*

No abstract available.
Arachnoid* ; Arachnoiditis* ; Magnetic Resonance Imaging* ; Tuberculosis*