1.Anthelmintic effect of oxantel and oxantel/pyrantel tablets against intestinal nematode infections.
Soon Hyung LEE ; Chul Yong SONG ; Jung Kyoo LIM
The Korean Journal of Parasitology 1977;15(2):121-126
Present trial was carried out to evaluate the anthelmintic efficacy of oxantel/pyrantel tablets against intestinal nematode infections, and to determine the efficacy of oxantel tablels against Trichuris infection. A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg. All stool examinations were done before the treatment and 3 weeks after the treatment. The cellophane thick smear (Kato's technique) and Stoll's dilution egg counting method were employed. The results of the trial were summarized as follows: The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3 percent and 97 percent in trichuriasis, 100 percent each in ascariasis and ancylostomiasis. The oxantel tablet treated group demonstrated a cure rate of 90.9 percent and an egg reduction rate of 96.3 percent in the treatment of Trichuris. There were no detectable objective and subjective side effects in this trial. Both oxantel/pyrantel and oxantel pamoate tablets were readily accepted and well tolerated.
parasitology-helminth-nematoda
;
Enterobius vermicularis
;
Ancylostoma duodenale
;
Trichuris trichiura
;
chemotherapy-oxantel/pyrante
;
oxantel pamoate
2.A study on the lipids of Chinese liverfluke, Clonorchis sinensis.
Soon Hyung LEE ; Chul Yong SONG ; Byong Ha CHO
The Korean Journal of Parasitology 1977;15(2):109-114
The present study was undertaken to observe the quality and quantity of lipids in the adult worms of Chinese liverfluke, Clonorchis sinensis. Lipid extraction was done by the methods of Folch et a1. (l957) and Kenny (1952), and then the extracted lipid fractions of the worm were separated by thin layer chromatography. Those fractions were also subjected to perform the quantitative analyses of glycerides, cholesterols and phospholipids. The results obtained were summarized as follows: Total amount of glyceride was 37.56 mg per gram of worm tissue and the amount of monoglyceride was 8.34 mg per gm; diglyceride, 15.46 mg per gm; and triglyceride, 12.86 mg per gm. Total amount of cholesterol was 3.30 mg per gm of worm tissue, and the esterified cholesterol (1.72 mg/gm) was a little more than that of free cholesterol (1.26 mg/gm). The following 8 phospholipids were detected in the worm tissue of C. sinensis, i.e., lysophosphatidylcholine, phosphatidylcholine, phophatidylinositol, sphingomyelin, phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and an unknown phospholipid.
parasitology-helminth-trematoda
;
Clonorchis sinensis
;
biochemistry
;
glyceride
;
cholesterol
;
phospholipid
;
lipid
;
lysophosphatidylcholine
;
phosphatidylcholine
;
phophatidylinositol
;
sphingomyelin
;
phosphatidylglycerol
;
phosphatidylserine
;
phosphatidylethanolamine
3.An experimental study on the mouse intraperitoneal inoculation of the adult worm of Clonorchis sinensis.
Chul Yong SONG ; Soon Hyung LEE ; Je Geun CHI
The Korean Journal of Parasitology 1977;15(2):75-92
The present experimental study was undertaken to observe the chronological change of the worm structure of Clonorchis sinensis and the pathological findings of the liver when this fluke was inoculated to the mouse intraperitoneally. The recovery rate, survival rate, location and size of the inoculated worms as well as the pathological changes of the liver were investigated for the comparison among the groups of mice, classified by number of worms and the duration of experiment. The results obtained were summarized as follows: The recovery and survival rates of the worms decreased especially 28 days after the inoculation. Most of worms (90.l percent) were collected from the peritoneal cavity and some of worms were found tightly adherent to the capsules of the liver, spleen, stomach, intestine and diaphragm. There were no worms recovered penetrated in the parenchymes of these organs. The mean worm size after inoculation was smaller than that before inoculation. At the 10th day after the inoculation, the shrinkage of posterior portion of the worm body was observed. Remarkable atrophy in the reproductive organs of the worm, such as spermatheca, testes, vitelline glands and ovary was frequently observed at the 10th day of inoculation. Histopathologically the liver failed to show any parasitic worm inside the intrahepatic biliary system. However, multiple well formed egg-containing granulomas were present along the liver capsule. These necrotic granulomas were occasionally found under the fibrotic liver capsule. Focal necrosis and focal phlebitis together with vascular dilatation were prominent features seen in the liver. The bile duct in the liver showed mild dilation of the lumen, flattening of epithelial cells and periductal small round cell infiltration. Neither adenomatous hyperplasia nor portal fibrosis was seen in the whole experimental groups. Foci of intralobular micro-granulomas were found in some experimental animals. The worms recovered in the capsule of the liver were degenerated and necrotized. Usually, there were remarkable capsulitis and granuloma formation around the eggs.
parasitology-helminth-trematoda
;
Clonorchis sinensis
;
pathology
;
liver
;
spleen
;
stomach
;
intestine
;
diaphragm
;
granuoma
;
peritoneal cavity
4.A Case of Pericarditis as a Complication of Meningococcal Meningitis.
Moo Young OH ; Seung Won PARK ; In Soon PARK ; Chul Ho KIM ; Soon Yong LEE
Journal of the Korean Pediatric Society 1983;26(8):799-802
No abstract available.
Meningitis, Meningococcal*
;
Pericarditis*
5.A Case of Aplastic Anemia Following hepatitis.
Gae Soon YEO ; Doo Kweon KIM ; Chul Ho KIM ; Soon Yong LEE
Journal of the Korean Pediatric Society 1990;33(6):864-869
No abstract available.
Anemia, Aplastic*
;
Hepatitis*
6.A Case Report of Congenital Hypoplastic Anemia.
Hyun Gi JUNG ; Tai Gyo WHANG ; In Soon PARK ; Chul Ho KIM ; Soon Yong LEE
Journal of the Korean Pediatric Society 1983;26(3):279-283
No abstract available.
Anemia, Hypoplastic, Congenital*
7.A Case of Hereditary Spherocytosis.
Eui Lim CHOI ; Chul Hwan PARK ; Tae Gyu HWANG ; In Soon PARK ; Soon Yong LEE
Journal of the Korean Pediatric Society 1983;26(11):1120-1124
No abstract available.
8.A Case of Chronic Atrial Tachycardia.
Seung Won PARK ; Moo Young OH ; In Soon PARK ; Chul Ho KIM ; Soon Yong LEE
Journal of the Korean Pediatric Society 1983;26(9):905-908
No abstract available.
Tachycardia*
9.3 Cases of Congenital Hypothyroidism.
Chul Hwan PARK ; Moo Young OH ; Tae Gyu HWANG ; Soon Yong LEE ; Yeon Soon KIM
Journal of the Korean Pediatric Society 1987;30(3):320-326
No abstract available.
Congenital Hypothyroidism*