A case of Peutz-Jeghers syndrome was experienced with melanin pigmentation in the oral cavity and lips associated small intestine polyposis. Diagnosis of Peutz-Jeghers syndrome was established by clinical characteristics of skin and X-ray studies of gastrointestinal tracts.
Diagnosis ; Gastrointestinal Tract ; Intestine, Small ; Lip ; Melanins ; Mouth ; Peutz-Jeghers Syndrome* ; Pigmentation ; Skin

Hidradenitis suppurativa is a rare disease which represents a chronic suppurative and scarring process, affecting the apocrine glands due to persistent bacterial infection and apocrine dysfunction. We have experienced a case of hidradenitis suppurativa, 22-year-old female which involved both axillary region. Diagnosis was established by clinical characteristicsymptoms, histopathological findings and bacteriological examinations.
Apocrine Glands ; Bacterial Infections ; Cicatrix ; Diagnosis ; Female ; Hidradenitis Suppurativa* ; Hidradenitis* ; Humans ; Rare Diseases ; Young Adult

No abstract available.
Adult* ; Human Body* ; Humans* ; Male*

No abstract available.
Bronchogenic Cyst*

Atypical fibroxanthoma(AFX) occurs most on sun-exposed area of the head and neck of elderly person. It has an excellent prognosis after conservative, but complete, excision. However, because of its potential, albeit small, for metastasis, it is widely regarded as a low-grade sarcoma. We present herein two cases of atypical fibroxanthoma. The case 1 was a 86-year-old female who had a small egg-sized, dome shaped nodule with eroive surface on the left cheek. The other case was a 60-year-old male who had solitry bean-sized, nodulo-ulcerative lesion on the vertex. Immunohistochemical studies revealed positive reaction for vimntin and a-antichymo trypsin. These patients have received completely total surgical ecis on and remained free of recurrence for a period of about, 2 years follow up.
Aged ; Aged, 80 and over ; Cheek ; Female ; Follow-Up Studies ; Head ; Humans ; Male ; Middle Aged ; Neck ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Sarcoma ; Skin* ; Trypsin

No abstract available.
Hysterectomy* ; Lymph Node Excision* ; Lymph Nodes*

No abstract available.
Hysterectomy* ; Lymph Node Excision* ; Lymph Nodes*

Using immunohistochemical methods, the authors investigated the distribution of tubulin in normal skin and 31 skin tumors, including 11 benign skin tumors and 20 malignant skin tumors, In normal skin, tubulin was strongly expressed in basal cells of the epidermis, sebaceus celis and dermal nerves. Myoepithelial cells, ductalI cells of sveat ducts and outer root sheath cells of hair follicles stained moderat,ely. Lermal fi broblasts showed no staining. In benign tumors including keratoacanthoma, trichoepithelioma, and nevocellular nevus the strornal fibroblast.s were entirely tubulin negative as well as the turnor cells. In basal cell carcinoma, the stromal fibroblasts were negative',whereas tumor cells were weakly positive. In squarnous cell carcinoma(SCC), tumor cells weri, tubulin positive weakly, the degree of tubulin expression of its stroma1 fibroblasts tencied to be in proportional to the grade of malignanr.u. Tumor cells of malignant melanoma and nevocellular nevus were tubulin positive moderately bist the stromal fibrobla.sts were strongly positive only in the cases of malignant melanoma. These results show that the degree of the tubulin; expression in adjacent, stromal cells of epidermal tumors is in proportiona.l to that of their malignancy, These suggest that the expression of tubulin in fibroblasts surrounding tumor cells of malignant melanoma and SCC reflects a stromal alt,eration that might contribute to tumor in vasion, and play a role for cellular motility.
Carcinoma, Basal Cell ; Epidermis ; Fibroblasts ; Hair Follicle ; Keratoacanthoma ; Melanoma ; Nevus ; Skin* ; Stromal Cells ; Tubulin*

No abstract available.

Previous observations have demonstrated that fibronectia (FN) is deposited high abundance in basal cell carcinoma (BCC) stroma. Since FN is a glycoprotein which promotes interaction between cells and extracellular matrix, it may been important component of slowly expansile carcinoma such as BCC. Furthermore, BCCs aggressiveness varies with it's histologic appearance. The authors investigated distribution of plasma FN (pFN) in 8 BCC cases with various histologic types (3 nodulocystic type, 2 infiltrative type, 2 keracotic type, 1 adenoid type) and 4 squamous cell carcinomas (SCC), which have a more aggrcisive biologic behavior than BCC using immunohistochemical staining. In normal skin, pFN was strongly positive at the clenzoepidermal junction and perivascular area with a linear pattern, and in the papillary dermis with a reticular pattern, and was weakly positive in the reticular dermis. In BCC, pFN was strongly positive in nodulocystic BCC, with the highest concentration along the periphery of the tumor island in a filamentous pattern, .hereas, it was moderately positive in adenoid, keratotic, infiltrative BCC stroma. In SCC, pFN was weakly positive around tumor the margins with a thin, coarse deposition These results show that with epidermal tumors, the degree of the pFN expression in stroma is propotional to their aggressiveness.
Adenoids ; Carcinoma, Basal Cell* ; Carcinoma, Squamous Cell ; Dermis ; Extracellular Matrix ; Fibronectins* ; Glycoproteins ; Plasma* ; Skin