No abstract available.
Humans ; Mothers*

No abstract available.
Animals ; Hepatocytes* ; Organelles* ; Rats*

No abstract available.
Geriatrics* ; Primary Health Care*

The ability of nicotinic acid and its substitutes to increase cutaneous blood flow has been measured by laser Doppler flowmeter in 30 healthy human volunteers. We applied nicotinarnide, nicotinic acid ethyl ester, nicotinic acid methyl ester, hexyl nicozinate each in an acqeous solution at a concentration of 10 mM/liter for 10 minutes occlusion on the forearm. The change of blood flow was serially checked at 5 to 10 minutes intervals for one hour. The study results were as follows : l. The relative maximum cutaneous blood flow response was in following order nicotinic acid methyl ester(100%), nicotinic acid ethyl ester(98%), hexyl nicotinate (84%) and nicotinic acid(63%). However, there was no statistically significant difference(p>0.05) between each drug. There was statististically significant difference between nicotinamide and all other nicotinic acid substitutes(p<0.05). 2. The time required to reach maximum blood flow response was 6.7 minutes for hexyl nicotinste, 10 minutes for nicotinic acid ethyl ester, 12.5 minutes for nicotinic acid methyl ester and 20 minutes for nicotinic acid. However, there was statistically significant difference between hexyl nicotinate and nicotinic acid only(p<0.05). 3. Significant decrease of cutaneous blood flow was observed one hour after the removal of the patches in all drugs.
Flowmeters ; Forearm ; Healthy Volunteers ; Niacin* ; Niacinamide

No Abstract available.
Diagnosis* ; Sleep Apnea, Obstructive*

PURPOSE: This study was conducted to assess the effects of x-irradiation on the expression of the novel glutathione S-transferase K1 gene. MATERIALS AND METHODS: Human glutathione S-transferase K1 (hGSTK1) DNA was purified and ligated to a pcDNA3.1/Myc-His(+) vector for the overexpression of hGSTK1 gene. MCF-7 cells were transfected with or without the recombinant hGSTK1 gene, and irradiated with 6 MV x-ray. After incubation of 14 days, cell survival was measured and compared. The expression of hGSTK1 and the effect of x- irradiation on hGSTK1 expression were also estimated in MCF-7 cells transfected with or without the hGSTK1 gene by RT-PCR. RESULTS: Following 2 to 12 Gy of x-irradiation, the cell survivals were higher in the MCF-7 cells transfected with the hGSTK1 gene than in those without transfection. Despite the higher cell survival in the hGSTK1-transfected cells, RT-PCR for hGSTK1 mRNA revealed no significant differences according to radiation dose, fractionation, and time after irradiation. CONCLUSION: The MCF-7 cells transfected with the hGSTK1 gene showed higher cell survival than those without transfection of the gene. The hGSTK1 gene might be associated with the radiosensitivity of MCF-7 cell line and further analysis should be needed.
Cell Survival ; DNA ; Glutathione Transferase* ; Glutathione* ; Humans ; MCF-7 Cells* ; Radiation Tolerance ; RNA, Messenger ; Transfection

Contact Dermatitis due to cosmetics is also common in Korea. as in other developed countries. However. detection of the causative antigens is in a difficult situation due to many reasons. We have routinely patch tested with Japanese cosmetic series patch test allergens, Types 17 and 18 in addition to Hollister standard battery and patients own cosmetics to 4Q cases of suspected cosmetic contact dermatitis who have visited our Environmental and Occupational Clinic during the past one year. The study result was as follows. Total 55% ositive reaction related to cosmetics was observed in 4p patch tested patients. 2 The most frequently observed antigens were hydroxycitronellal, benzyl saliylate and cinnamic alcohol.
Allergens ; Asian Continental Ancestry Group ; Dermatitis, Contact* ; Developed Countries ; Humans ; Korea ; Patch Tests*

The efficacy of Thayer-Martin media (abbreviated TM media) recently introduced by the government, is a great concern to us. The results of culture on TM media are compared with the results obtained from Gram stained filrn. The subjects were 235 male patients with urethral discharge who visited the VD clinic of Choong-ku Puhlic Health Center in Seoul during 3 months period from 21th May to 20th August 1979. CDC recommendations are closely followed for Gram staining as well as for cultural identification. Among 151 positives with Gram staining, 142 were also culture positive (94.0%) while 8 were negative(5.2%) indicating reasonably good correlation. One patient was culturally positive(0. 8%) while negative by Gram staining. TM media supplied by Seoul Metropolitian Institute of Public Health which was used for this study is considered to be adequate.
Centers for Disease Control and Prevention (U.S.) ; Gonorrhea* ; Humans ; Male ; Public Health ; Seoul

INTRODUCTION: Sleep has numerous important physiological and cognitive functions that may be particularly important to elite athletes. Sleep deprivation can have significant effects on athletic performance. However, there are few published data related to the amount of sleep obtained by elite athletes. We investigated sleep patterns of Korean women golfers using sleep-related questionnaires. METHODS: For this study, 98 Korean university women golfers and 46 age- and sex-matched controls were recruited. All subjects were asked to complete the self-administered sleep questionnaire consisting of questions about habitual sleep patterns (sleep onset time, sleep latency, awakening time in the morning, day time napping time), exercise habits, Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISS), Pittsburgh Sleep Quality Index (PSQI), validation of the Perceived Stress Scale (PSS), and Beck Anxiety Inventory (BAI). RESULTS: The sleep onset time was significantly earlier (pm 23 : 05 +/- 00 : 52 and 00 : 14 +/- 00 : 51 ; t = 5.287, p < 0.001), the waking time was later (am 07 : 21 +/- 01 : 09 and 6 : 35 +/- 00 : 32; t = -2.715, p = 0.008), the weekday total sleep time was greater (417.77 +/- 78.18 minute and 351.52 +/- 77.83 minute ; t = 4.406, p = 0.001), and the daytime nap time was greater (77.73 +/- 41.28 minute and 20.22 +/- 33.03 minute ; t = 7.623, p < 0.001) in the golf athletes compared to the controls. The PSQI scores were significantly lower, but estimated sleep latency and ESS, ISS, PSS, and BAI scores were not different among the two groups. CONCLUSION: This study suggests that Korean university women golfers have good sleep patterns resulting in no difference in sleep-related stress compared to age- and sex-matched control students.
Anxiety ; Athletes ; Athletic Performance ; Female ; Golf ; Humans ; Surveys and Questionnaires ; Sleep Deprivation ; Sleep Initiation and Maintenance Disorders

No abstract available.
Risk Factors*