1.Diagnostic Evaluation of Dyspnea.
Journal of the Korean Medical Association 1997;40(4):493-500
No abstract available.
Dyspnea*
2.Two cases of intrabronchial neurilemmoma.
Chul Min AHN ; Heung Bum LEE ; Yong Chul LEE ; Yang Keung RHEE
Tuberculosis and Respiratory Diseases 2000;49(2):225-230
Neurilemmoma is rare benign tumor originating from the Schwann cell of the nerve sheath. Intrabronchial neurilemmoma are extremely rare and only few cases have been reported previously in Korea. Neurilemmoma at all ages but are most common in persons between the ages of 20 and 50 years. It affects the head, neck, flexor regions of the extremities. Neurilemmoma was confirmed histologically because of the presence of Verocay bodies, Antoni A or B tissue pattern and of S-100 protein. We report two cases of intrabronchial neurilemmoma with chronic coughing and nonspecific radiologic findings.
Cough
;
Extremities
;
Head
;
Humans
;
Korea
;
Neck
;
Neurilemmoma*
;
S100 Proteins
3.Peak Expiratory Flow in Normal Healthy Korean Subjects Measured by mini-Wright Peak Flow Meter.
Young Sam KIM ; Ahn Ae RAN ; Se Kyu KIM ; Joon CHANG ; Chul Min AHN ; Jai Joon OH ; Sung Kyu KIM
Tuberculosis and Respiratory Diseases 2001;50(3):320-333
BACKGROUND: Peak expiratory flow (PEF) provides a simple, quantitative, and reproducible measure of the existence and severity of airflow obstructions. Peak flow meters are designed to monitor the condition asthma patients. There are many reports showing the normal predicted value of PEF in other countries. studies on healthy Korean adults have been performed in a relatively small sample number and a lower limit for the normal value was not reported. therefore, an attempt to provide normal predictive PEF value with a lower limit was made. METHOD: The PEF(Mini-Wright peak Flow Meter) measurements and spirometry were done in 233 men and 631 woman without history of respiratory disease. all subjects were non-smokers with no respiratory symptoms. the normal predictive value and its lower limit were developed by multiple regression analysis. The result was compared with regression equations in other reports. RESULTS: The regression equation for the normal PEF predictive value(L/min) is 25.117+4.587×Age(year)-0.064×Age2+2.931×Height(cm) in men in men(R2=0.25), and 146.942-0.011×Age2+1.795×Height(cm)+0.836×Weight (kg) in women(R2=0.21). The regression equation for the lower limit of this value (L/min) is 25.117+4.587×Age(year)-0.064×Age2+1.936×Height (cm) in men, and 146.942-0.011×Age2+1.232× Height (cm)+0.481×Weight (kg) in women. The residuals were normally distributed. The PEF in Korean males was similar to those reported in British and Japanese subjects. The PEF in Korean females was similar to that in British subjects, But higher than the PEF in Japanese subjects. The lower limit of normal value was 71% of normal predictive PEF value in men and 76% in women. CONCLUSION: The normal predictive PEF value and its lower limit was measured from 233 male and 631 female asymptomatic, lifelong non-smoking participants. The normal predictive value was different from those of other studies on Korean subjects. Therefore, further studies are required.
Adult
;
Asian Continental Ancestry Group
;
Asthma
;
Female
;
Humans
;
Male
;
Reference Values
;
Spirometry
4.A clinical analysis of 50 cases of renal transplantation.
Hyung Min JIN ; Chul Woo YANG ; Suk Young KIM ; Chang Joon AHN ; Rae Sung KANG
The Journal of the Korean Society for Transplantation 1993;7(1):95-105
No abstract available.
Kidney Transplantation*
5.Right pneumonectomy in a patient with poor pulmonary function.
Suck Jung JOO ; Doo Yun LEE ; Hae Kyoon KIM ; Chul Min AHN
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(11):1218-1220
No abstract available.
Humans
;
Pneumonectomy*
6.Toxoplasma gondii: ultrastructural localization of specific antigens and inhibition of intracellular multiplication by monoclonal antibodies.
Boo Young LEE ; Myoung Hee AHN ; Hyun Chul KIM ; Duk Young MIN
The Korean Journal of Parasitology 2001;39(1):67-75
This experiment was focused on the characterization of anti-Toxoplasma monoclonal antibodies (mAbs) and the effect of mAbs on the parasite invasion of mouse peritoneal macrophages. Twenty eight mAbs including M110, M556, R7A6 and M621 were characterized by Ab titer, immunoglobulin isotyping and western blot pattern. Antibody titer (optical density) of 4 mAbs, M110, M556, R7A6 and M621, were 0.53, 0.67, 0.45 and 0.39 (normal mouse serum; 0.19) with the same IgG1 isotypes shown by Enzyme-linked immunosorbent assay (ELISA). Western blot analysis showed that M110, M556, R7A6 and M621 reacted with the 33 kDa (p30), 31 kDa (p28), 43 kDa and 36 kDa protein. Immunogold labelling of mAbs M110, M556, R7A6 and M621 reacted with the surface membrane, dense granules and parasitophorous vacuolar membrane (PVM), rhoptries and cytoplasm of tachyzoite, respectively. For in vitro assay, preincubation of tachyzoites with four mAbs, M110, M556, R7A6 and M621 resulted in the decrease of the number of infected macrophages (P < 0.05) and the suppression of parasite multiplication at 18 h post-infection. Four monoclonal antibodies including M110 (SAG1) were found to have an important role in the inhibition of macrophage invasion and T. gondii multiplication in vitro, and these mAbs may be suitable for vaccine candidates, diagnostic kit and for chemotherapy.
Animals
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*Antibodies, Monoclonal/pharmacology
;
*Antibodies, Protozoan/pharmacology
;
Antigens, Protozoan/*analysis/immunology
;
Cells, Cultured
;
Depression, Chemical
;
Macrophages, Peritoneal/parasitology
;
Mice
;
Mice, Inbred ICR
;
Support, Non-U.S. Gov't
;
Toxoplasma/growth & development/*immunology
7.Retroperitoneal Synovial Sarcoma: A case report.
Seoung Wan CHAE ; Jung Weon SHIM ; Hye Kyung AHN ; Min Chul LEE ; Young Euy PARK
Korean Journal of Pathology 1995;29(4):540-542
Synovial sarcoma most commonly affects the extremities, especially the lower thigh and knee region. However, a smaller number develops in a central or axial distribution, an area which encompasses the trunk, orofacial, cervical and parapharyngeal regions. The retroperitoneum is an extremely unusual site and has never been recorded in the literature as primary a site for synovial sarcoma. We investigated a case of retroperitoneal synovial sarcoma in a 40-year-old woman. The specimen consisted of fragmented large bulky multinodular masses separated by slit-like spaces. The tumor was 130 gm in weight. Microscopically, the tumor was composed of nests of plump ovoid to polygonal shaped cells and bundles of spindle shaped cells, which had vesicular nuclei and a small amount of cytoplasm. In some areas, there were cleft like spaces and pseudoglandular structures lined by flat or cuboidal cells. Myxoid change, collagen deposition, foci of calcification and osseous metaplasia were also present. Immunohistochemically, the polygonal cells and some of the spindle cells reacted positively for keratin. The spindle cells, especially in the perivascular area were positive for vimentin. S-100 protein and GFAP were negative in both type of cells.
Female
;
Humans
8.Role of Growth Factors and Cytokines on Bleomycin Induced Pulmonary Fibrosis.
Yong Hee LEE ; Soon Hee JUNG ; Chul Min AHN ; Sung Kyu KIM ; Sang Ho CHO
Tuberculosis and Respiratory Diseases 1997;44(4):871-888
BACKGROUND: It is now thought that the earliest manifestation of idiopathic pulmonary fibrosis is alveolitis, that is, an accumulation of inflammatory and immune effector cells within alveolar walls and spaces. Inflammatory cells including alveolar macrophages and resident normal pulmonary tissue cells participate through the release of many variable mediators such as inflammatory growth factors and cytokines, which contribute to tissue damage and finally cause chronic pulmonary inflammation and fibrosis. This study was performed to investigate the source and distribution pattern of transforming growth factor-beta1(TGF-beta1), platelet derived growth factor(PDGF), basic fibroblast growth factor(bFGF), interleukin 1(IL-1), interleukin 6(IL-6), tumor necrosis factor-alpha(TNF-alpha) and the role of these mediators on bleomycin(BLM)-induced pulmonary injury and fibrosis in rats. METHOD: Wistar rats were divided into three groups(control group, BML treated group, BML and vitamine E treated group). Animals were sacrifices periodically at 1, 2, 3, 4, 5, 7, 14, 21, 28 days after saline or BLM administration. The effects were compared to the results of bronchoalveolar lavage fluid analysis, light microscopic findings, immunohistochemical stains for six defferent mediators(TGF-beta1, PDGF, bFGF, IL-1, IL-6 and TNF-alpha) and mRNA in situ hybridization for TGF-beta1. RESULTS: IL-1 and IL-6 are maximally expressed at postbleomycin 1~7th day which are mainly produced by neutrophils and bronchiolar epithelium. It is thought that they induce recruitment of inflammatory cells at the injury site. The expression of IL-1 and IL-6 at the bronchiolar epithelium within 7th day is an indirect evidence of contribution of bronchiolar epithelial cells to promote and maintain the inflammatory and immune responses adjacent to the airways. TNF-alpha is mainly produced by neutrophils and bronchiolar epithelial cells during 1~5th day, alveolar macrophages during 7~28th day. At the earlier period, TNF-alpha causes recruitment of inflammatory cells at the injury site and later stimulates pulmonary fibrosis. The main secreting cells of TGF-beta1 are alveolar macrophages and bronchiolar epithelium and the target is pulmonary fibroblasts and extracellular matrix. TGF-beta1 and PDGF stimulate proliferation of pulmonary fibroblasts and TGF-beta1 and bFGF incite the fibroblasts to produce extracellular matrix. The vitamine E and BLM treated group shows few positive cells(p<0.05). CONCLUSION: After endothelial and epithelial injury, the neutrophils and bronchiolar epithelium secrete IL-1, IL-6, TNF-alpha which induce infiltration of many neutrophils. It is thought that variable enzymes and O2 radicals released by these neutrophils cause destruction of normal lung architecture and progression of pulmonary fibrosis. At the 7~28th day, TGF-beta1, PDGF, bFGF, TNF-alpha secreted by alveolar macrophages sting pulmonary fibroblasts into proliferating with increased production of extracellular matrix and finally, they make progression of pulmonary fibrosis. TNF-alpha compares quite important with TGF-beta1 to cause pulmonary fibrosis. Vitamine E seems to decrease the extent of BLM induced pulmonary fibrosis.
Animals
;
Bites and Stings
;
Bleomycin*
;
Blood Platelets
;
Bronchoalveolar Lavage Fluid
;
Coloring Agents
;
Cytokines*
;
Epithelial Cells
;
Epithelium
;
Extracellular Matrix
;
Fibroblasts
;
Fibrosis
;
Idiopathic Pulmonary Fibrosis
;
In Situ Hybridization
;
Intercellular Signaling Peptides and Proteins*
;
Interleukin-1
;
Interleukin-6
;
Interleukins
;
Lung
;
Lung Injury
;
Macrophages, Alveolar
;
Necrosis
;
Neutrophils
;
Pneumonia
;
Pulmonary Fibrosis*
;
Rats
;
Rats, Wistar
;
RNA, Messenger
;
Transforming Growth Factor beta
;
Transforming Growth Factor beta1
;
Tumor Necrosis Factor-alpha
;
Vitamins
9.Treatment for Multi-drug Resistant Tuberculosis.
Tuberculosis and Respiratory Diseases 1999;46(6):757-766
No abstract available.
Tuberculosis, Multidrug-Resistant*
10.Giant Cystic Adenomatoid Tumor of the Uterus: A case report.
Young Hee CHOI ; Seoung Wan CHAE ; Hye Kyung AHN ; Min Chul LEE ; Young Euy PARK
Korean Journal of Pathology 1993;27(1):85-87
Adenomatoid tumor of the uterus is a rare benign neoplasm which has been known as mesothelial origin. Characteristically, it appears as a small nodular lesion less than 2.0cm in the myometrium of subserosal region. We describe a case of giant adenomatoid tumor of the uterus having multicystic gross appearance. A 49-year-old woman complained of vaginal bleeding. The tumor was an intramural mass with maximum diameter of 10 cm and located at posterior wall of the uterus. Histologically, the tumor was composed of multiple cystic cavities of variable size lined by flattened cells, lying among thin septa of connective tissue. Immunohistochemically, the cells are positive for low molecular weight cytokeratin(CAM 5.2) and are negative for factor VIII.
Female
;
Humans