Malignant germ cell tumors occur in children and young women in reproductive age, of all the germ cell malignancies, only pure dysgerminomas had a high cure rate prior to 1970. This was due to the exquisite radiosensitivity of these tumors. Multiple-agent chemotherapy has dramatically improved the pmgnosis of patients with malignant ovarian germ cell tumors. Clinicopathological analysis was performed on 21 cases of malignant germ cell tumors of the ovary, 9 cases at the department of Obstetrics & Gynecology, Kyung-pook National University Hospital, 4 cases, at the department of Obstetrics and Gynecology, Dong-guk University Kyungju Hospital and 8 cases, at the department of Obstetrics and Gynecology, Dae-gu Fatima Hospital during the period 10 years from July. 19S8 to June. 1997 The results were summarized as follows: 1. The mean age of the patients was 21.8 years old, ranging from 10 to 61 years old. 2. Main initial symptoms were abdominal distension(33.3%), abdominal mass palpation(33.3%), abdominal pain(28.6%), amenorrhea(4.8%) in order. 3. Histologically, the tumors were classified as immature teratoma(57.1%), dysgerminoma(19%), mixed germ cell tumor(9.5%), endodermal sinus tumor(9.5%), embryonal cell carcinoma(4.8%). 4, According to FIGO classification Stage I was the most prevalent(57.1%) at the time of diagnosis while Stage III was forward in 48.6%, Stage II in 9.5%, and no Stage IV, 5. The 5-year survival rate was 80.4% and three patients have died of malignancy and the other 18 patients live without disease from 11 to 102 months, with a median follow-up of 34.2 months. 6. Prognostic factors of malignant germ cell tumors in this study were the clinical stage, the presence of ascites and the residual tumor mass.
Ascites ; Child ; Classification ; Daegu ; Diagnosis ; Drug Therapy ; Dysgerminoma ; Endoderm ; Female ; Follow-Up Studies ; Germ Cells* ; Gyeongsangbuk-do ; Gynecology ; Humans ; Middle Aged ; Neoplasm, Residual ; Neoplasms, Germ Cell and Embryonal* ; Obstetrics ; Ovary* ; Radiation Tolerance ; Survival Rate

No abstract available.
Erythropoietin* ; Humans* ; Renal Dialysis*

Alpasia cutis congenita is an anomaly characterized by absence of localized areas of the integument. The most common type of aplasia cutis congenita is Aplasia cutis congenita limited to the scalp, although other areas of the body may also be involved. We experienced a case of aplasia cutis congenita in a male newborn infant. The skin defects were extensive with symmetrical involvement of lower extremities. The multiple bullae were found on the both fingers and toes. No similar conditions and other associated congeital anomalies were found in the family membes of this particular case. The light microscopic examinaton of the denuded skin areas how absence of epidemis and the demis contain atrophic and hypoplastic adnexa. The bullae have a split within the dermis below lamina densa on electron microscopy. The skin defects were healed by supportive therapy for 4weeks.
Dermis ; Ectodermal Dysplasia* ; Epidermolysis Bullosa* ; Fingers ; Humans ; Infant, Newborn ; Lower Extremity ; Male ; Microscopy, Electron ; Scalp ; Skin ; Toes

No abstract available.
Dacryocystorhinostomy*

BACKGROUND: Aspiration of gastric contents into the lungs is one of the most feared complications during anesthesia. Various factors combine to make pediatric patients more susceptible to regurgitation and aspiration than adults. We compared the risk of incidence of acid aspiration in two groups, after examining the pH, and volume of gastric contents in pediatric and adult patients. METHODS: This study was carried out with inpatients scheduled for elective surgery under general anesthesia. Sixty patients from 1 to 13 years old were included in the pediatric age group, and sixty patients from 18 to 60 years old were included in the adult age group. After induction of anesthesia and stabilization of the condition of the patient, gastric contents were collected via a 10 - 18 French Salem Sump tube. Gastric volume and pH were measured. RESULTS: The mean gastric volume in the pediatric group was significantly higher than those in the adult group, whereas, The mean gastric pH in the adult group was significantly higher than those in the pediatric group. CONCLUSIONS: We concluded that pediatric patients have a lower gastric pH but a higher gastric volume than adult patients.
Adolescent ; Adult* ; Anesthesia ; Anesthesia, General ; Child* ; Humans ; Hydrogen-Ion Concentration ; Incidence ; Inpatients ; Lung ; Middle Aged

BACKGROUND: For anesthesia in cesarean section N2O and low concentrations of inhalation anesthetics are regarded as the anesthetic agent of choice. But a low level of anesthesia frequently leads to increased maternal hemodynamic responses and awareness. The effects of a 3 microgram/kg fentanyl bolus injection after umbilical cord clamping was evaluated in 20 full-term parturients, scheduled for elective cesarean section, versus to 20 parturients without fentanyl. METHODS: The forty parturients (ASA physical status 1, 2) scheduled for cesarean section were randomized to either a N2O-enflurane (E group) or a N2O-enflurane-fentanyl (F group). Thiopental sodium (4 mg/kg) and succinylcholine (1.5 mg/kg) were administered intravenously for the induction and endotracheal intubation. Anesthesia was maintained with 50% N2O and 1% enflurane in oxygen until delivery. After delivery, the intravenous injection of 0.5 mg/kg of atracurium was administered, controlled ventilation was applied to maintain PetCO2 at 30 to 35 mmHg with N2O (3 L/min) and O2 (1.5 L/min). Immediately after clamping the umbilical cord, 3 microgram/kg of fentanyl (F group only) was administered. Heart rate, blood pressure, awareness, recovery time, postoperative complication and recall were evaluated. RESULTS: Heart rate values at 10 and 20 min after umbilical cord clamping and 5 min after extubation, and mean arterial pressure at 5, 10 and 20 min after umbilical cord clamping in group F were found to be significantly lower than in group E. CONCLUSIONS: We conclude that N2O-enflurane-fentanyl at 3 microgram/kg is clinically satisfactory in anesthesia for cesarean section, having no adverse effects on the mother.
Anesthesia ; Anesthesia, General ; Anesthetics, Inhalation ; Arterial Pressure ; Atracurium ; Blood Pressure ; Cesarean Section* ; Constriction* ; Enflurane ; Female ; Fentanyl* ; Heart Rate ; Hemodynamics ; Humans ; Injections, Intravenous ; Intubation, Intratracheal ; Mothers ; Oxygen ; Postoperative Complications ; Pregnancy ; Succinylcholine ; Thiopental ; Umbilical Cord* ; Ventilation

OBJECTIVES: Over the last 30 years, despite the increasing sophistication in medical care, the mortality of acute renal failure(ARF) has remained virtually unchanged at 40-50%, but the reasons remain unknown. This study intend to identify prognostic risk factors influencing survival and predict the mortality in ARF patients. METHODS: We retrospectively analyzed 152 patients with ARF who required renal replacement therapy, or whose serum creatinine level above 5 mg/dl, from Jan. 1988 to May. 1995. Multiple factors which may influence mortality were evaluated by univariate and multivariate analysis. RESULTS: 1) Of the 152 patients, 97 were male and 55 were female. The mean age was 47 years and the overall mortality was 36.8%. 2) Based on the univariate analysis, age>60 years, cause of ARF, APACHE II score, number of failing organs, peak serum creatinine level, PaO2, coma, hypotension, ARDS, GI bleeding, ventilatory support, need for antiarrhythmics, DIC, cardiovascular failure, pulmonary failure, neurological failure, and gastrointestinal failure were all significant factors discriminating between survivors and nonsurvivors(p<0.05) 3) By multivariate analysis, hypotension, coma, ventilatory support, and age over 60 years were significant independent predictors influencing survival in ARF patients and logistic equation and logit score were as follows : z=-2.04+1.32(age over 60)+2.18(hypotension)+2.88 (ventilatory support) + 3.28(coma) P=ez/(1+ ez) 4) In ROC(receiver-operating characteristic)curve, when the cutoff point was 0.2, maximum sensitivity was 75% and maximum specificity was 82%. CONCLUSION: In ARF, prognostic risk factors for mortality were age over 60 years, hypotension, assisted ventilation and coma. The logit score by multiple analysis is a reliable predictor of mortality in ARF patients, however the further studies are required to confirm these results.
Acute Kidney Injury* ; APACHE ; Coma ; Creatinine ; Dacarbazine ; Female ; Hemorrhage ; Humans ; Hypotension ; Male ; Mortality* ; Multivariate Analysis ; Renal Replacement Therapy ; Retrospective Studies ; Risk Factors* ; Sensitivity and Specificity ; Survivors ; Ventilation

Polydipsia occurs frequently in chronic schizophrenic patients, some of whom develop hyponatremia. Although the underlying pathophysiology of polydipsia among psychiatric patients, recent reports indicate that clozapine treatment improves polydipsia-hyponatremia in schizophrenia. Two schizophrenic patients with polydipsia, followed for more than two years, showed improvement on clozapine. Case 1 was a patient without history of hyponatremia who improved from polydipsia and psychosis. Case 2 was an inpatient with polydipsia and hyponatremia who showed improvement of polydipsia and did nor recur hyponatremia. The limited information provided by these case reports suggest the need for controlled studies of the clozapine effect on schizophrenic patients with polydipsia.
Clozapine* ; Humans ; Hyponatremia ; Inpatients ; Polydipsia* ; Psychotic Disorders ; Schizophrenia*

This study was designed to compare the percutaneous endoscopic gastrostomy(PEG) tube feeding with the nasogastric(NG) tube feeding for the patients with dysphagia after the stroke, and to find out the most optimal timing for the PEG tube feeding. We monitored the nutritional parameters, the frequency and the timing of complications, and other risk factors in 54 stroke patients with dysphagia. In the group of patients with the nasogastric(NG) tube feeding, a reduction in nutritional parameters was greater than in the group of patients with PEG tube feeding. Especially the reduction in serum hemoglobin and albumin level was statistically significant. Thirteen cases of aspiration pneumonia who had frequent self removal of feeding tubes developed in the group with NG tube feeding. Most cases of aspiration pneumonia in the NG tube feeding group developed within the first 2 weeks. Complications from the PEG tube feeding group were three cases of upper gastrointestinal bleeding and three cases of local infection. There were no correlations between the duration of dysphagia and the location of brain lesions, the history of tracheostomy, the age, the initial mental status, or the artificial ventilation. But, there was a significant prolongation of duration of dysphagia in the group of patients who had a vocal cord palsy, an absence of gag reflex, a paralytic dysarthria and a prolonged intensive medical care. We conclude that the PEG tube feeding is a safer and the more effective method to provide a long term enteral nutrition to patients with neurological dysphagia than the NG tube feeding. Since the most complications developed in the first 2 weeks, the PEG tube feeding should be applied within the initial 2nd to 3rd week for the stroke patients with dysphagia and aspiration risks. Further prospective study will be needed to decide an ideal timing of PEG tube feeding after an acute stroke.
Brain ; Deglutition Disorders ; Dysarthria ; Enteral Nutrition* ; Gastrostomy* ; Hemorrhage ; Humans ; Pneumonia, Aspiration ; Reflex ; Risk Factors ; Stroke* ; Tracheostomy ; Ventilation ; Vocal Cord Paralysis

OBJECTIVE: It has been well known that many of patients with stroke have developed secondary poststroke complications which encompassed pneumonia, urinary tract infection, depression, fall and/or fracture, deep vein thrombosis, decubitus ulcer, and others. Our experience with Korean stroke patients indicated that the incidences of such complications were not as high as reported on the western literatures. This study was aimed to obtain the precise data in terms of occurrence of poststroke complications in Korea as compared with those in western countries. METHOD: Nine-hundred-eighty-four (984) charts of Stroke patients who were hospitalized at Asan Medical Center during the periods of 3 years from 1994 through 1997 were reviewed. The data from the review were compared with the data excerpted from the literatures. RESULTS: The review of charts disclosed that there was a great disparity of the incidences of complications in stroke patients between Korea and Western (U.S.A.) countries. The incidences of all stroke complications were uniformly much lower in Korea than Western countries. CONCLUSION: Compared with western countries, stroke patients in Korea presented significantly lower incidences of poststroke complications: 5.8% pneumonia; 3.7% urinary tract infection; 3.0% fall; 2.7% decubitus ulcer; and 2.4% deep vein thrombosis. Although there were a many factors accounting for lower incidences of complication, an extensive nursing service around the clock seemed to be a major attributing factor. However, the nursing services such as position change, massage, joint motion exercise etc. have been rendered not by registered nurse but by a caregiver hired by patient's family or a member of patient's family. Since patient's family or caregiver had not formally received an education of health care, their service may be liable for incidences against patient's quality care. Therefore, the strengthening of the manpower of registered nurse is essential to meet a standard of nursing service.
Caregivers ; Chungcheongnam-do ; Delivery of Health Care ; Depression ; Education ; Humans ; Incidence* ; Joints ; Korea* ; Massage ; Nursing Services ; Pneumonia ; Pressure Ulcer ; Rehabilitation ; Stroke* ; Urinary Tract Infections ; Venous Thrombosis