1.A Case of Palmar Digital Vein Thrombosis.
Ju Hee HAN ; Hyun Jeung JU ; Chul Jong PARK ; Kyung Ho LEE
Korean Journal of Dermatology 2016;54(10):822-823
No abstract available.
Thrombosis*
;
Veins*
2.A case of lead poisoning.
Mee Kyung JANG ; Kuk Sin JANG ; Young Chul HAN ; Dong Gui JANG ; Chul Ju JUNG
Journal of the Korean Pediatric Society 1992;35(9):1286-1290
No abstract available.
Lead Poisoning*
3.A case of salmonella group C meningitis.
Dae Chul KIM ; Ju Hyun HAN ; So Young LEE ; Jeh Hoon SHIN ; In Joon SEOL
Journal of the Korean Pediatric Society 1992;35(10):1449-1453
No abstract available.
Meningitis*
;
Salmonella*
4.Recent developments in systemic chemotherapy for hepatocellular carcinoma.
The Korean Journal of Hepatology 2008;14(1):4-11
Despite recent developments in various chemotherapeutic agents and the performing of numerous clinical trials, chemotherapy still produces unsatisfactory results in hepatocellular carcinoma due to poor clinical benefit compared with untreated controls and its significant toxicity. The presence of liver cirrhosis, its complications, and decreased liver function increase the complexity of chemotherapy. There is recent evidence that targeted agents and antiangiogenic agents such as thalidomide are somewhat effective whilst having minimal toxicities. Some patients are cured by aggressive chemotherapy alone or in combination with other modalities. Therefore, if a patient is in good condition and the tumor shows some response to chemotherapy, aggressive chemotherapy might be considered. Although conventional chemotherapeutic agents are not very effective in many patients, their utility might be improved by lowering toxicities using reduced doses or by selecting only responsive patients if adequate chemosensitivity tests are available. Imaging studies have been conventional tools for evaluating tumor responses, but their results are not always reliable. Establishing criteria for accurately determining tumor responses is urgently needed, along with better chemotherapeutic drugs and regimens.
Antibodies, Monoclonal/therapeutic use
;
Antimetabolites, Antineoplastic/therapeutic use
;
Antineoplastic Agents, Hormonal/therapeutic use
;
Carcinoma, Hepatocellular/*drug therapy
;
Combined Modality Therapy
;
Deoxycytidine/analogs & derivatives/therapeutic use
;
Fluorouracil/analogs & derivatives/therapeutic use
;
Humans
;
Immunologic Factors/therapeutic use
;
Liver Neoplasms/*drug therapy
;
Tegafur/therapeutic use
5.The Effect of Milk on the Bioavailability of 6-mercaptopurine.
Sun Kyu PARK ; Ran Ju KIM ; Pyoung Han HWANG ; Soo Chul CHO ; Jung Soo KIM
Journal of the Korean Pediatric Society 1994;37(12):1732-1737
The purine antimetabolite 6-Mercaptopurine (6-MP) has been in clinical use for over 30 years and is still a widely used agent in the treatment of childhood acute lymphoblastic leukemia. The bioavailibility, clinical efficacy and toxicity of 6-MP administered orally for maintenance therapy of children with acute lymphoblastic leukemia are highly variable in many studies, as well as at differnt times in same patient. there are many factors affecting the bioavailibility of 6-MP. The most notably factor being that concomitantly administered drugs and foods might contribute to a decrease in the bioavailibity of this drug. In our sociocultural environment milk is a major constituent of child's foods. Cow's milk contains a high concentration of xanthine oxidase, which could potentially transform 6-TM into 6-thioxanthine (6-TX) and 6-thiouric acid (6-TUA) which have no more therapeutic effects. In this study, we evaluated the effect of various milk products on the bioavailability of 6-MP. Incubation at 37degrees C for 30 min raw or pasteurized milk resulted in transformation of a large quantity of clinically relevant concentration of 6-MP into 6-TUA. The concomitant adminstration of folic acid and allopurinol has markedly inhibitory effect on the 6-MP destroying activity of milk at clinically relevant concentrations. These observations may help to optimize modalities of administration of 6-MP for the treartment of patients with childhood leukemia.
6-Mercaptopurine*
;
Allopurinol
;
Biological Availability*
;
Child
;
Complement Factor B
;
Folic Acid
;
Humans
;
Leukemia
;
Milk*
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma
;
Xanthine Oxidase
6.Could HBsAg Quantification Predict Sustained Response Following Antiviral Therapy for Chronic Hepatitis B?.
The Korean Journal of Gastroenterology 2011;58(6):364-366
No abstract available.
7.Molecular Typing of Salmonella typhi by Random Amplified Polymorphic DNA Analysis.
Chul Hun CHANG ; Jeong Whan SHIN ; Han Chul SON ; Chul Min KIM ; Ju Hyun LEE
Korean Journal of Clinical Microbiology 1998;1(1):51-56
BACKGROUND: In the year 1996, there were some outbreaks of Salmonella typhi infection in Pusan and therefore, the incidence of S. typhi infection was markedly increased in comparison with the previous year. To differentiate the isolates epidemiologically, a random amplified polymorphic DNA(RAPD) fingerprinting method has been developed. METHODS: A total of 9 arbitrary primers were screened with S. typhi strains isolated in Pusan, 1996. This allowed selection of a panel of primers capable of detecting DNA polymorphisms among S. typhi isolates. This panel was used to examine 54 strains of S. typhi, which had been isolated in Pusan including the cases of outbreaks that was previously characterized by phage typing. RESULTS: Four single primers and one combination of two primers were selected to discriminate the S. typhi isolates. RAPD analysis resolved the 54 strains into 20 different subtypes. At least two outbreaks were found by RAPD analysis. The isolates of E1 phage type, which are the most common in Korea, were perfectly differentiated with each other, except the strains isolated within the outbreaks. CONCLUSION: The RAPD approach is the useful epidemiologic tool to S. typhi subtyping, which is providing high discriminatory power. There were at least two outbreaks when the epidemic Salmonella infections of Pusan in 1996 had been occurred. The primers or their comb ination capable to discriminate the S. typhi isolates were described.
Animals
;
Bacteriophage Typing
;
Bacteriophages
;
Busan
;
Comb and Wattles
;
Dermatoglyphics
;
Disease Outbreaks
;
DNA*
;
Incidence
;
Korea
;
Molecular Typing*
;
Salmonella Infections
;
Salmonella typhi*
;
Salmonella*
8.Expression of bcl-2 and Apoptosis and Its Relationship to Clinicopathological Prognostic Factors in Breast Cancer - A Study with Long Term Follow-up.
Ju Han LEE ; Eun Sook LEE ; Chul Hwan KIM
Journal of Korean Breast Cancer Society 2004;7(2):92-97
PURPOSE: The aims of this study were to evaluate the prognostic roles of bcl-2 and apoptosis in patients with breast cancer after long term follow-up, and the correlation with the known clinicopathological parameters. METHODS: 88 primary breast cancers were selected between March 1988 and February 1994. These cases were clinically followed up over 10 years (median follow-up 139 months). The immunohistochemical expression of bcl-2 protein and apoptosis were studied, and the findings compared to the clinicopathological parameters, such as estrogen receptor (ER), progesterone receptor (PR) and clinical stage. RESULTS: The bcl-2 protein was identified in 42 (47.7%) cases. The bcl-2 expression correlated positively with large tumor sizes, well differentiated tumors, and ER expression. No significant associations were seen between the apoptosis index and the clinicopathological parameters. The expression of bcl-2 and apoptosis were not correlated with the survival rate. The clinical stage and status of lymph node metastases were correlated with the survival rate, but no other clinicopathological parameters were correlated. CONCLUSION: Long term follow-up for breast cancer patients revealed that the expression of bcl-2 and apoptosis was not correlated with the survival rate.
Apoptosis*
;
Breast Neoplasms*
;
Breast*
;
Estrogens
;
Follow-Up Studies*
;
Humans
;
Lymph Nodes
;
Neoplasm Metastasis
;
Prognosis
;
Receptors, Progesterone
;
Survival Rate
9.Two Cases of Poland Syndrome.
Kul Ha YOO ; Ki Soo PAI ; Byung Ju CHUNG ; Chul LEE ; Dong Gwan HAN ; Jong Doo LEE
Journal of the Korean Pediatric Society 1989;32(5):713-717
No abstract available.
Poland Syndrome*
;
Poland*
10.Survival and Prognostic Factors in Patients with Small Hepatocellular Carcinoma after Curative Resection.
Gwang Hoon WOO ; Jung Hwan YOON ; Chul Ju HAN ; Hyo Suk LEE ; Kun Wook LEE ; Chung Yong KIM
Korean Journal of Medicine 1997;53(5):686-693
BACKGROUND: The survival in patients with hepatocellular carcinoma (HCC) has recently been improved by the advancement in the early detection of HCC. Among the various treatment modalities, the surgical resection has been considered as the most effective for small HCC, and the clinical course of patients with small HCC who underwent curative resection is known to be dependent on the etiology of HCC. Since the differences in the etiology of HCC depend on the different geographical area, it is necessary to verify the clinical outcomes and their affecting factors in patients with small HCC after curative resection in Korea, one of the hepatitis- B-virus(HBU)-endemic areas. METHODS: A total of 89 patients with small HCC (
Carcinoma, Hepatocellular*
;
Classification
;
Follow-Up Studies
;
Hepatitis B Surface Antigens
;
Humans
;
Korea
;
Liver
;
Liver Cirrhosis
;
Mortality
;
Prognosis
;
Recurrence
;
Retrospective Studies
;
Seoul
;
Survival Rate