Lovastatin, a competitive inhibitor of the rate limiting enzyme in cholesterol biosynthesis was administered to 34 patients with primary hypertlipidemia, 20 mg once daily with the evening meal. Patients experienced mean total and LDL cholesterol reductions of 30.9% and 34.0% respectively. HDL cholesterol level was significantly increased by 15.4% and plasma triglyceride level was decreased by 11.2%. maximal hypocholesterolemic effects were evident at 8 weeks, after which the effects were stable. Adverse effects were noted in 2 patients who had mild gastrointestinal symptoms, that subsided after discontinuing the drug. We concluded that lovastatin is a well tolerated and effective agent for the treatment of primary hyperlipidemia.
Cholesterol ; Cholesterol, HDL ; Cholesterol, LDL ; Humans ; Hyperlipidemias* ; Lovastatin ; Meals ; Plasma* ; Triglycerides

No abstract available.
Leiomyoma* ; Stomach*

No abstract available.
Astrocytes* ; Gene Expression* ; Humans* ; Polymerase Chain Reaction*

Brain Ischemia* ; Hemodilution* ; Intracranial Embolism ; Rabbits*

Adventitial cystic disease of the popliteal artery is a rare disorder that causes localized stenosis or occlusion by compression of the vessel lumen. The disease produces lower extremity claudication, typically in young and middle-aged men. We report a case of the adventitial cystic disease of the popliteal artery in a 55-year-old man with symptom of left calf claudication. Diagnosis was done by ultrasound, angiography, and magnetic resonance imaging. The patient was treated with resection of the diseased popliteal artery followed by interposition of saphenous vein graft. Postoperatively, the symptom and sign resolved completely.
Angiography ; Constriction, Pathologic ; Diagnosis ; Humans ; Lower Extremity ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Popliteal Artery* ; Saphenous Vein ; Transplants ; Ultrasonography

No abstract available.
Mesenteric Cyst*

We report a case of perigastric histiocytic sarcoma (HS) involving the lesser omental sac in a 30-year-old man. HS is an exceedingly rare malignancy of mature tissue histiocyte. The tumor was a multi-lobulated, bulging enhancing mass in the lesser omentum with metastasis to lymph nodes and liver. The tumor consisted of diffuse non-cohesive proliferation of pleomorphic large oval to round neoplastic cells with giant cells showing vesicular chromatin and ample eosinophilic cytoplasm. In some areas, the tumor cells showed spindling with elongation of the nuclei and cellular shapes. Many of the tumor cells, especially giant forms contained phagocytosed lymphocytes. Immunohistochemical analysis of the tumor cells showed expression of leukocyte common antigen, CD68, lysozyme, vimentin, CD4, and CD163. Ki-67 index was 50-60%. After the operation, he was treated with chemotherapy, but the response was poor.
Adult ; Antigens, CD45 ; Chromatin ; Cytoplasm ; Eosinophils ; Giant Cells ; Histiocytes ; Histiocytic Sarcoma ; Humans ; Liver ; Lymph Nodes ; Lymphocytes ; Muramidase ; Neoplasm Metastasis ; Omentum ; Sarcoma ; Vimentin

Trichoadenoma is a rare, benign, cutaneous tumor with differentiation towards the infundibular portion of the pilosebaceous canal. Clinically, it occurs as a solitary tumor, and most commonly on the face. Histologically, it is characterized by numerous horn cysts lined with squamous epithelium and solid tumor islands in the dermis. A 25-year-old female patient presented with a solitary 0.7x0.7cm sized, skin-colored, central, depressed papule on the right cheek, which had been present for 7 years. Histopathologic findings showed the characteristic features of trichoadenoma.
Adult ; Animals ; Cheek ; Dermis ; Epithelium ; Female ; Horns ; Humans ; Islands

No abstract available.
Appendix* ; Pseudomyxoma Peritonei*

No abstract available.
Hepacivirus* ; Hepatitis C* ; Hepatitis* ; Myositis*