This study was carried out not only to determine blood alcohol levels by time but also to examine the changes of working ability and reaction speed after ingestion of alcohol. Fifteen healthy students aged from 21 to 27 volunteered as subjects for this study. Liguor (So)oo) in concentration of 25% ethyl alcohol was administrated with the amount of lml of ethyl alcohol per kg of body weight to the subjects. The concentration of alcohol in the blood were determined by the "Alcohol Sensor 100" at 5, 30, 60 and 90 minutes after the administration of alcohol. Also, the choice reactiontest, the eye-hand coordination test and kraepelin test were examined at the same time after checking of alcohol concentration in the blood. The results of this study can be summarized as follows. 1. Mean blood alcohol level changes resulting from administration of lml of ethyl alcohol per kg of body weight were 0.16%(160+/-57mg/100ml, 0.10%(100+/-42mg/100m1), 0.08%(80+/-36mg/100ml) and 0.03% (30+/-24mg/100%1) at the 3, 30, 60 and 90 minutes after the administration respectively. The peak in the concentration of blood alcohol was 5 miniutes after the ingestion according to alcohol examination by the respiration. 2. As for choice reaction test, reaction times became prolonged as blood alcohol levels increased. The reaction time showed a significant changes when the blood alcohol concentration reached 0.08% or more after alcohol ingestion. 3. In eye and hand coordination test, the accuracy of the performance became decreased as blood alcohol levels increased. The difference of accuracy of the test was significantly shown when alcohol levels in the blood reached 0.08% or more after alcohol intake. 4. As for kraepelin test, the abilities of calculation also became lowered as blood alcohol levels increased. The abilities of calculation differed signigicantly from control group when aichool levels of 0.08% and more.
Body Weight ; Eating ; Ethanol ; Hand ; Humans ; Reaction Time ; Respiration

No abstract available.
Low Back Pain* ; Prevalence* ; Risk Factors*

A 21-year-old male suffered from generalized anhidrosis and heat intolerance for about 15 years. Other clinical features included multiple angiokeratoma on the back, scrotum and extremities, together with ocular involvement. The electronmicroscopic studies of the skin demonstrated laminated intracytoplamic inclusions in the endothelial cells, pericytes of dermal vessels, fibroblasts and eccrine glandular cells. a Galactosidase assay of leukocytes from the patient and his uncle showed nearly absence of the activity,
Angiokeratoma ; Endothelial Cells ; Extremities ; Fibroblasts ; Galactosidases ; Hot Temperature ; Humans ; Hypohidrosis* ; Leukocytes ; Male ; Pericytes ; Scrotum ; Skin ; Young Adult

The present study was carried out to find a simple and safe in. vitro test for phtotoxic drugs. Authors selected two strains of Salmonella typhimurium(TA98 and TA102) which have been used in Ames test for the detsction of mutagenecity af various chemical substances. Both strains are genuine products of genetic enzineering. The etrain TA98 should be highly vulnerable to ultraviolet radition because it lacks normal I)NA excision repair gene. The strain TA102 was chosen as control since it maintained the DNA repair gene. These strains were subjected to increasing dosea of UVA with or without pretreatment of 8 methoxypsoralsn(8-MOP) which is a prototype of photatoxic druge. The authors made use of a perforated stain-less steel template which provided a simple and eosy monitoring of ultraviolet irradiation effects i.e. clear zones due to inhibition of the atrains could be determined. By using this methad, the authors acquired the following results .' I. 8-MOP alone exerted no inhibition on both strains at concentration upto 100mg /ml. 2. UVA irradiation alone showed no growth inhibition at dose upto 5J/cm. 3. UVA irradiation after pretreatment with 8 MOP resulted varying growth inhibition in proportion to irradiation doses. 4. Authors found a suitable concentration of 8-MOP for this test is 10pg/ml. With this ccncentrstion, minimal phatatoxic dose of UVA were O.l J/cm for the strain TA98 and 1.0J/cm for the strain TA102 respectively.
Dermatitis, Phototoxic ; DNA Repair ; Methoxsalen ; Salmonella ; Steel

One of the most difficult problems confronting the orthopedic surgeon today is what to do when faced with a large defect in a peripheral nerve. Recent advances in engineering and neurophysiology have improved our technical ability to understand the consequences of severing a nerve. We have treated a large traumatic ulnar nerve defect with microsurgical nerve graft technique. In a follow-up study of twehre monthes post surgery, the results were satisfactory.
Follow-Up Studies ; Neurophysiology ; Orthopedics ; Peripheral Nerves ; Transplants ; Ulnar Nerve

We report a case of juvenile xanthogranuloma associated with neurofibromatosis. The patient was a 10-month-old female who had multiple yellowish papules on the face and shoulders A Biopsy of these lesions revealed foamy histiocytes with an admixture of inflammatory cells and Touton giant cells. Multiple, more than 6, cafe-au-lait spots, measuring more than 1.5cm in diameter were scattered on the trunk and buttocks Retardation of physical growth and development was observed.
Biopsy ; Buttocks ; Cafe-au-Lait Spots ; Female ; Giant Cells ; Growth and Development ; Histiocytes ; Humans ; Infant ; Neurofibromatoses* ; Shoulder ; Xanthogranuloma, Juvenile*

We report a case of juvenile xanthogranuloma associated with neurofibromatosis. The patient was a 10-month-old female who had multiple yellowish papules on the face and shoulders A Biopsy of these lesions revealed foamy histiocytes with an admixture of inflammatory cells and Touton giant cells. Multiple, more than 6, cafe-au-lait spots, measuring more than 1.5cm in diameter were scattered on the trunk and buttocks Retardation of physical growth and development was observed.
Biopsy ; Buttocks ; Cafe-au-Lait Spots ; Female ; Giant Cells ; Growth and Development ; Histiocytes ; Humans ; Infant ; Neurofibromatoses* ; Shoulder ; Xanthogranuloma, Juvenile*

Twenty-two cases of non-tuberculous spinale pidural abscess treated at the Dept. of Neurosurgery, Kyungpuk University Hospital during the past 7 years from 1962 to 1969 were observed clinically. The results were summarized as follows: 1. The ratio between male and female was 2; 1. The peak age incidence of these cases was between 40 and 50 years old with 36% of patients and between 10 and 20 years old with 27% of patients falling into this range. 2. The most important source of infection was the furuncle or abscesses of the skin, which was responsible for 50% of total known cases. The most frequent site of infection was thoracolumber area, which was responsible for 50% of total cases. Among others, thoracic (32%) and lumbar (18%) areas were included. Bacterial culture was performed in 14 cases and staphylococcus was isolated in 11 cases. 3. As for clinical symptoms 12 cases revealed back pain, there showed fever, root pain and headache in some cases. Paraplegia or paraparesis observed in 19 cases, sphincter disturbance in 18 cases, sensory deficits in 17 cases, back tenderness and stiff neck were included in these groups. Pyogenic pus was aspirated in 3 cases through lumbar puncture from the epidural space. Manometric studies during the lumber puncture revealed a partial or complete blockage in 13 cases. The CSF analysis showed an increase of protein in 15 cases and an increase of cell count in 12 cases. 4. The operative findings were classified in three types. The type I, which was composed of pus only, was 4%, The type Ii of pus and granulation tissue was 50% and the type II of granulation tissue and adhesion was 36%. The postoperative prognosis has revealed to be excellent in 5 cases, good recovery in 8 cases and unimprovement of neurological deficits in 6 cases. Three cases succumbed to uncontrollable sepsis and pneumonia.
Abscess ; Back Pain ; Cell Count ; Epidural Abscess* ; Epidural Space ; Female ; Fever ; Furunculosis ; Granulation Tissue ; Headache ; Humans ; Incidence ; Male ; Middle Aged ; Neck ; Neurosurgery ; Paraparesis ; Paraplegia ; Pneumonia ; Prognosis ; Punctures ; Sepsis ; Skin ; Spinal Puncture ; Staphylococcus ; Suppuration ; Young Adult

The present study was carried out to investigate the HHsAg in the normal skin, dis- eased skin and skin specimens of window period of HBsAg positive patients in their serum with normal liver function. This study was done by immunoperoxidase techniques using the monoclonal antibody to hepatitis E3 surface antigen and by electron microscopy. Immunoperoxidase staining was dane on twenty specimeris of normal skin Group .D twenty specimens of diseased skin (15 cases of dermographism, 2 cases of purpura, 1 case of follicuht,is and 1 cases of morbilliform eruption) (Ciroup II ) and three specimens of normal skin af window period (Group III ) of HBsAp positive patients in their serum. Twelve cases of Group I, eleven cases of Group IL (1(J cases of dremographism and 1 rase of purpura) and two cases of Group II were stained positively for HBsAg. Positive sites were keratinocyte of epidermis, sweat gland, blood vessel and hair follicle. Electron microscopy failed to reveal viral particle, The above resuts suggest the possibility of transmission of viral hepatitis B thraugh the skin and skin appendages.
Antigens, Surface ; Blood Vessels ; Epidermis ; Hair Follicle ; Hepatitis B Surface Antigens ; Hepatitis B* ; Hepatitis* ; Humans ; Immunoenzyme Techniques ; Keratinocytes ; Liver ; Microscopy, Electron ; Purpura ; Skin* ; Sweat Glands ; Virion

No abstract available.
Cervix Uteri* ; Female