The aim of this study was to investigate viral etiology in dilated cardiomyopathy (DCM) by polymerase chain reaction (PCR) or nested reverse tanscription PCR (RT-PCR), and characterize the enteroviral RNA presented in the clinical specimens. Twenty-eight paraffin-embedded heart tissue samples were assayed to detect cytomegalovirus, herpes simplex virus type 1, type 2, parvovirus, adenovirus, and enterovirus (EV) with each specific primer. Of these 28 patients (mean age: 27, M: 24, F: 4), 26 were histologically diagnosed as DCM and 2 as myocardial infarction (MI). Nested RT-PCR detected enteroviral RNA in 7 (26.9%) of 26 patients with DCM, and none of patients with MI. And none of DNA viruses tested were detected from the samples. Amplified products were also genotyped by single-variation of EV is present in the explanted heart tissues from patients with DCM. Although most of the sequences among the wild isolates have the greatest similarity to those of coxsackievirus B3, there are specific regions of variable sequences (no 490 - no 510). The data suggest that enterovirus may be a major viral pathogen for the DCM in Korea and nucleotide sequence data indicate that coxsackievirus B3 may be a leading etiologic agent of DCM.
Adenoviridae ; Base Sequence ; Cardiomyopathy, Dilated* ; Cytomegalovirus ; DNA Viruses ; Enterovirus ; Heart* ; Herpesvirus 1, Human ; Humans ; Korea ; Myocardial Infarction ; Parvovirus ; Polymerase Chain Reaction ; RNA*

PURPOSE: There have been few studies of bee-sting anaphylaxis in patients visiting the Emergency Department. Thus, this study was performed to observe the general characteristics and the various clinical presentations of beesting anaphylaxis. METHODS: The study was performed for two years between January 2001 and December 2002. The objects of the study were 42 patients who were diagnosed as having anaphylaxis due to bee stings among patients who visited Pundang Jae-Saeng Hospital's Emergency Department. Emergency medicine residents directly followed the beesting anaphylaxis protocol. RESULTS: Males were 33 cases (78.6%), and female wewe 9 cases (21.4%). Severe anaphylaxis occurred in 25 cases (59.5%) and mild anaphylaxis in 17 cases (40.5%). The most frequent month was September with 12 cases (28.6%), and the most frequent place was the mountains with 15 cases (35.7% ). Of the 18 cases (42.9%) presenting with a prior bee-sting history, the incidence of severe anaphylaxis was 14 cases (77.8%) whilst of the 24 cases (57.1%) without any prior history, the incidence was 11 (45.8%)(p= 0.037). CONCLUSION: The history of a previous beesting is more related to the incidence of severe anaphylaxis, and of those patients presenting with systemic symptoms, the incidence rate of severe anaphylaxis is higher at 59.5%. Thus, it seems reasonable to treat patients presenting with systemic symptoms from bee stings or with a history of previous bee stings with early administration of epinephrine and to keep them under close observation.
Anaphylaxis ; Bee Venoms ; Bees* ; Bites and Stings* ; Emergencies* ; Emergency Medicine ; Emergency Service, Hospital* ; Epinephrine ; Female ; Humans ; Incidence ; Male

PURPOSE: This study was conducted to estabilish the prevalence, clinical features and relationship between ECG findings and echocardiographic findings of Wolff-Parkinsion-White(WPW) syndrome in asymptomatic preschool children. METHODS: An electrocardiographic screening study was performed on 77,824 preschool children in Jeonbuk province from April, 1999 to August, 2001. Patients with WPW syndrome underwent echocardiographic study. RESULTS: Twenty three patients with WPW syndrome were discovered by electrocardiographic screening of preschool children. The prevalence rate was 2.9 per 10,000 preschool children and there was no significant sexual difference. Two patients had a history of symptoms related to tachyarrythmia. According to the ECG classification of Rosenbaum et al., five patients were type A and 18 were type B. Utilizing the criteria of Gallagher et al, right anterior, 12 patients; right anteiror paraseptal, four patients; left anteiror, three patients. Nineteen of 23 patients underwent echocardiographic study. Four of five patients with type A WPW syndrome had abnormal early systolic anterior motion of left ventricular posterior wall. Twelve of 14 patients with type B had abnormal interventricular septal motion characterized by early sytolic posterior motion immediately after inscription of the delta wave. CONCLUSION: The prevalence rate of preschool children in Jeonbuk province was 2.9/10,000. By the classification according to the electrocardiographic findings, the accessory pathway location was dominant right side than left side. In the echocardiographic study, type A WPW syndrome showed abnormal left ventricular posterior wall motion and type B WPW showed abnormal interventricular septal motion.
Child, Preschool* ; Classification ; Echocardiography* ; Electrocardiography* ; Humans ; Jeollabuk-do ; Mass Screening ; Prevalence ; Wolff-Parkinson-White Syndrome*

The objective of study was to evaluate the incidence and mortality rates of disasters and mass casualty incidents (MCIs) over the past 10 yr in the administrative system of Korea administrative system and to examine their relationship with population characteristics. This was a population-based cross-sectional study. We calculated the nationwide incidence, as well as the crude mortality and injury incidence rates, of disasters and MCIs. The data were collected from the administrative database of the National Emergency Management Agency (NEMA) and from provincial fire departments from January 2000 to December 2009. A total of 47,169 events were collected from the NEMA administrative database. Of these events, 115 and 3,079 cases were defined as disasters and MCIs that occurred in Korea, respectively. The incidence of technical disasters/MCIs was approximately 12.7 times greater than that of natural disasters/MCIs. Over the past 10 yr, the crude mortality rates for disasters and MCIs were 2.36 deaths per 100,000 persons and 6.78 deaths per 100,000 persons, respectively. The crude injury incidence rates for disasters and MCIs were 25.47 injuries per 100,000 persons and 152 injuries per 100,000 persons, respectively. The incidence and mortality of disasters/MCIs in Korea seem to be low compared to that of trend around the world.
Cross-Sectional Studies ; Databases, Factual ; Disasters/*statistics & numerical data ; Humans ; Incidence ; Mass Casualty Incidents/*mortality ; Republic of Korea/epidemiology

BACKGROUND: Endoscopic Ultrasonography(EUS), a combination of endoscopy and ultrasonography is one of the most useful tools for diagnosis of digestive system diseases. EUS is useful in staging the primary tumor invasion and regional lymph node metastasis because of its ability to image the gut wall and adjacent structures in unique detail. We performed a study preoperatively for assessing the accuracy and limitation of EUS in gastric carcinoma. METHODS: In 75 patients(Male 54, Female 21, Mean age 62.3 years) with a gastric carcinoma confirmed by endoscopic biopsy, we performed EUS preoperatively. The results were compared with the postoperative histopathologic staging. RESULTS: 1) In assessing the depth of tumor invasion, EUS accuracy on depth of invasion was 76.0% and overstaging and understaging were 14.7% and 9.3%, respectively. 2) In assessing the lymph node metastasis, the accuracy rate of EUS was 65.3%. A rate of false-positive diagnosis was 27.3%, and a rate of false-negative diagnosis was 24.5%.3) In assessing the incidence of lymph node metastasis for each T stage, the involve rate was 10.5% in pT1, 36.4% in pT2, 95.7% in pT3, 100% in pT4. CONCLUSIONS: EUS is the most accurate diagnostic methods presently available to determine tumor infiltration depth and lymph node metastasis.
Biopsy ; Diagnosis ; Digestive System Diseases ; Endoscopy ; Endosonography* ; Esophagus* ; Female ; Humans ; Incidence ; Intestines* ; Lymph Nodes ; Neoplasm Metastasis ; Stomach* ; Ultrasonography

No abstract available.
Acalculous Cholecystitis* ; Churg-Strauss Syndrome* ; Colitis, Ischemic* ; Ulcer*

PURPOSE: At the Emergency Department (ED), echocardiography of patients with chest pain, dyspnea, and syncope is essential to identify the underlying etiology such as acute coronary diseases or other cardiac diseases. Therefore, we studied the accuracy and the clinical value of echocardiography for use by the emergency physician as a tool for the identification and evaluation of cardiac diseases. METHOD: From first, September, 2003 to first, November, 2003, we collected the case histories of 40 patients with suspected cardiac diseases, on whom formal echocardiography had been performed within 2 hours after their initial ED echocardiography. The emergency physicians had a 4-hour didactic training course by cardiologists and 1 month of practical training at a formal echocardiography center, then, they performed the echocardiography using an Acuson ASPENT M ultrasound system with a 3.5-MHz phased-array transducer. Data from the emergency physicians and from the formal echocardiographers were analyzed using the wilcoxson sign test, and the correlation coefficient and p value were calculated. RESULT: There were 28 male patients (70.0%) and 12 female patients (30.0%) and the average age of all patients was 60.9+/-15.5 years. The left ventricular end diastolic diameters (LVEDD) from ED and formal echocardiography were, respectively, 44.6+/-7.9 mm and 48.7+/-6.6 mm (p=0.000), the interventricular septum thicknesses (IVS) were 11.6+/-3.6 mm and 10.9+/-3.0 mm (p=0.064), the left ventricular posterior wall thicknesses (LVPW) were 10.9+/-3.4 mm and 10.1+/-2.00 mm (p=0.178), the ejection fractions (EF) were 59.7+/-15.8% and 60.0+/-16.4%(p=0.312), the left atrium diameters were 36.5+/-6.3 mm and 37.0+/-5.8 mm (p=0.770), the aortic root diameters were 29.2+/-4.0 mm and 33.6+/-3.7 mm (p=0.001), and the inferior vena cava diameters (IVC) were 15.9+/-8.1 mm and 13.3+/-2.5 mm (p=0.444). Except for the LVEDD and the aortic root diameters, there were no significant differences between ED and formal echocardiography, and the presences of regional wall motion abnormalities (RWMA), relaxation abnormalities, right atrium enlargement (RAE), and right ventricle abnormalities were all concordant between the two groups. The correlation coefficients and the p values between ED and formal echocardiography were, respectively, 0.806 and 0.000 for LVEDD, 0.662 and 0.000 for IVS thickness, 0.725 and 0.000 for LVPW thickness, 0.922 and 0.000 for EF, 0.729 and 0.001 for left atrium diameter, 0.331 and 0.037 for aortic root diameter, and 0125 and 0.443 for IVS diameter. CONCLUSION: We suggest that ED echocardiography, like formal echocardiography, with additional focused training can measure and assess the structural and the functional parameters of the heart.
Chest Pain ; Coronary Disease ; Dyspnea ; Echocardiography* ; Emergencies* ; Emergency Medicine* ; Emergency Service, Hospital ; Female ; Heart ; Heart Atria ; Heart Diseases ; Heart Ventricles ; Humans ; Male ; Relaxation ; Syncope ; Transducers ; Ultrasonography ; Vena Cava, Inferior

PURPOSE: This study was performed to determine whether the anion gap, the base excess, the lactate, and the strong ion gap obtained in the emergency department correlate with the prognosis and whether the strong ion gap is the most useful marker compared to the prognostic ability of the anion gap, the base excess, and the lactate. METHODS: We reviewed the records of 106 patients admitted to the intensive care unit via the emergency department. We measured the anion gap, the base excess, and the lactate and we calculated strong anion gap by using a formula. We divided the patients into survivors and nonsurvivors and compared the prognostic abilities of the four variables by using the Student's t-test and receiver operator characteristic curves. RESULTS: The mean age of the patients was 67+/-14, and the numbers of males and females were similar (58 males vs 48 females). The number of survivors was 92 (86.7%), and that of nonsurvivors was 14 (3.2%). The anion gap ( 24.8+/-8.8 vs. 16.4+/-4.8 mmol/L, p value=0.000), the base excess (-11.9+/-8.7 vs. -3.49+/-6.5 mmol/L, p value = 0.001), the lactate (9.1+/-7.7 vs. 4.5+/-3.1 mmol/L, p value = 0.011 ) and the strong ion gap (16.6+/-3.6 vs. 10.9+/-3.7, p value=0.000) of the nonsurvivors were higher. All of the four varibles were associated with the prognosis, but among them, the strong ion gap discriminated most strongly with an area under the receiver operator characteristic curve of 0.866 (95% confidence interval, 0.787 to 0.92). CONCLUSION: The initial emergency-department acid-base variables, the anion gap, the base excess, the lactate and the strong ion gap have prognostic abilities, but the strong ion gap is the variable that most strongly predicts of mortality.
Acid-Base Equilibrium ; Critical Illness* ; Emergencies* ; Emergency Service, Hospital* ; Female ; Humans ; Intensive Care Units ; Lactic Acid ; Male ; Mortality ; Prognosis ; Survivors

PURPOSE: Acute otitis media(AOM) has variable clinical symptoms and is diagnosed with injection, bulging, and decreased mobility of tympanic membrane. There are many misdiagnoses because children who are suspected of having acute otitis media are uncooperative during diagnosis with an otoscope. An inaccurate diagnosis of acute otitis media when using an otoscope results in wasted of medical resourses and increased tolerance to antibiotics. Therefore, this study was conducted to evaluate the usefulness of a video otoscope as a tool of diagnosis of acute otitis media. METHODS: Among 416 patients who visited Pundang Jesaeng Hospital Emergency Medical Center with a complaint of otalgia from 1 October 2002 to 30 September 2003, we studied 51 patients who were followed up at the otorhinolaryngology depatment. Emergency Medicine residents recorded the findings for tympanic membrane by using an otoscope and by using a video otoscope. we used kappastatistics to carry out a prospective study in which the accuracy of diagnosis of AOM was analyzed by comparison with the confirmed diagnosis by an otolaryngologic specialist. RESULTS: In this study, the number of males was 24 (47%) and that of females was 27 (53%). Of the 51 Patients, 22 (43%) presented with rhinorrhea, 15 (29%) with cough, 11 (22%) with sputum, 10 (20%) with fever, 8 (16%) with a sore throat, 7 (14%) with otorrhea, 4 (8%) with hearing difficulty, 3 (6%) with irritability, 3 (6%) with tinnitus, 3 (6%) with vomiting and 2 (4%) with dizziness. A comparison of the diagnostic accuracy of AOM between otolaryngologic specialist and residents in emergency department, when was undertaken by using kappa statistics, and a diagnostic agreement of 65% (kappa=0.28) for the otoscope, and 76 %( kappa=0.45) for the video otoscope. The diagnostic sensitivity of acute otitis media by video otoscope was 75%, and specificity was 82%. CONCLUSION: When the tympanic membrane of the patient suspected of a having AOM is examined in an emergency medical center, video otoscopy should be a useful diagnostic tool for AOM owing to its high diagnostic accuracy.
Anti-Bacterial Agents ; Child ; Cough ; Diagnosis* ; Diagnostic Errors ; Dizziness ; Earache ; Emergencies ; Emergency Medicine ; Emergency Service, Hospital ; Female ; Fever ; Hearing ; Humans ; Male ; Otitis Media* ; Otitis* ; Otolaryngology ; Otoscopes* ; Otoscopy ; Pharyngitis ; Prospective Studies ; Sensitivity and Specificity ; Specialization ; Sputum ; Tinnitus ; Tympanic Membrane ; Vomiting

PURPOSE: A patient at the emergency department (ED) with blunt abdominal trauma may still have the possibility of liver injury, even though they are hemodynamically stable. Computed tomography (CT) scanning or ultrasonography (US) is available if they are hemodynamically stable. However ultrasonography (US) has technical differences between physicians depending on their skill and computed tomography (CT) is expensive and time consuming, while liver transaminase is widely available, relatively inexpensive. Therefore, we studied diagnostic value of liver transaminase as a screening test for liver injury in hemodynamically stable patients with blunt abdominal trauma. METHODS: From March 2000 to February 2001, we treated 44 hemodynamically stable patients with suspected blunt abdominal trauma who were patients with elevated liver transaminase. An evaluation protocol including patient's age, sex, injury mechanism, history, physical examination, Glasgow Coma Scale (GCS), Revised Trauma Score (RTS), Injury Severity Scale (ISS), liver transaminase, abdominal US and abdominal CT was prospectively performed on all patients by residents and the staff of the emergency department. Based on the confirmed diagnosis of abdominal CT, patients were divided into two groups: group I with liver injury and group II without liver injury. We analysed the two groups by using the t-test and the chisquare test, and calculated the sensitivity, the specificity and the predictive value of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) by using multiple cutoff values. RESULTS: There were 34 male patients (76.3%) and 10 female patients (23.7%) and the average age of all patients was 37 years. Triage RTS and GCS were, respectively, 11.7+/-0.7 and 13.9+/-2.1 in group I, and 11.4+/-1.2 and 13.2 +/-3.5 in group II, the differences between the two groups were statistically insignificant. The ISS was 26.8+/-9.4 in group I and 21.1+/-8.0 in group II, and the differences was statistically significant. AST and ALT were, respectively, 288.0+/-113.7 IU/L and 177.9+/-95.8 IU/L in group I and 148.1+/-84.8 IU/L and 95.1+/-59.8 IU/L in group II. The maximum value of the highest sensitivity and minimal specificity of AST and ALT, calculated using the receiver operator curve, were AST > 256.3 IU/L and/or ALT > 122.0 IU/L, for which the sensitivity and the specificity were 61.1% and 84.6%, and the positive and the negative predictive values were 73.3% and 75.8%, respectively. CONCLUSION: We recommend that all patient with suspected blunt abdominal trauma be evaluated using serum liver transaminase as a screening test for liver injury even though they are hemodynamically stable. If AST > 256.3 IU/L and/or ALT 122.0 >IU/L, they should be evaluated with abdominal CT to confirm liver injury.
Alanine Transaminase ; Aspartate Aminotransferases ; Diagnosis ; Emergency Service, Hospital ; Female ; Glasgow Coma Scale ; Humans ; Liver* ; Male ; Mass Screening ; Physical Examination ; Prospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Triage ; Ultrasonography