BACKGROUND: c-erbB-1 (epidermal growth factor receptor) and c-erbB-2 oncoprotein have common tyrosine kinase activities, and alteration in their expression has been defined in various visceral tumors. However, relatively little is known about their expression in skin tumors. OBJECTIVE: Our aim was to evaluate the distribution and expression pattern of c-erbB-1 and c-erbB-2 in skin neoplasms. METHODS: We have undertaken an immunohistochemical survey of c-erbB-1 and c-erbB-2 in the tissue specimens of keratoacanthoma (KA), actinic keratosis (AK), squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). RESULTS: Membranous c-erbB-1 expression had a tendency to be down-regulated in some specimens of SCC and dysplastic portions of AK. In invasive lesions of SCC, we observed increased cytoplasmic accumulation of c-erbB-1. Most specimens of BCC showed rather decreased expression of c-erbB-1 compared with other skin tumors. c-erbB-2 oncoprotein showed strong cytoplasmic staining in SCC, especially in the invasive tumor mass, and in some deeply dysplastic or hyperplastic portions of AK, though the difference of intensity was not striking between tumors. BCC revealed relatively weaker expression of c-erbB-2 than other skin tumors, which was similar in pattern to c-erbB-1. CONCLUSION: The expression patterns of c-erbB-1 and c-erbB-2 are altered in various skin neoplasms, and seem to be related to the dysplastic status or differentiation level of tumor cells.
Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cytoplasm ; Keratoacanthoma ; Keratosis, Actinic ; Protein-Tyrosine Kinases ; Skin Neoplasms ; Skin* ; Strikes, Employee

OBJECTIVES: To evaluate the occurrence of patient adverse events in Korean hospitals as perceived by nurses and examine the correlation between patient adverse events with the nurse practice environment at nurse and hospital level. METHODS: In total, 3096 nurses working in 60 general inpatient hospital units were included. A two-level logistic regression analysis was performed. RESULTS: At the hospital level, patient adverse events included patient falls (60.5%), nosocomial infections (51.7%), pressure sores (42.6%) and medication errors (33.3%). Among the hospital-level explanatory variables associated with the nursing practice environment, 'physician- nurse relationship' correlated with medication errors while 'education for improving quality of care' affected patient falls. CONCLUSIONS: The doctor-nurse relationship and access to education that can improve the quality of care at the hospital level may help decrease the occurrence of patient adverse events.
Accidental Falls ; Accidents, Occupational ; Adult ; Cross Infection/etiology ; Female ; Hospitals ; Humans ; Logistic Models ; Male ; Medication Errors ; Middle Aged ; Nurses/*psychology ; Odds Ratio ; Pressure Ulcer/etiology ; *Quality of Health Care ; Questionnaires

OBJECTIVES: To evaluate the occurrence of patient adverse events in Korean hospitals as perceived by nurses and examine the correlation between patient adverse events with the nurse practice environment at nurse and hospital level. METHODS: In total, 3096 nurses working in 60 general inpatient hospital units were included. A two-level logistic regression analysis was performed. RESULTS: At the hospital level, patient adverse events included patient falls (60.5%), nosocomial infections (51.7%), pressure sores (42.6%) and medication errors (33.3%). Among the hospital-level explanatory variables associated with the nursing practice environment, 'physician- nurse relationship' correlated with medication errors while 'education for improving quality of care' affected patient falls. CONCLUSIONS: The doctor-nurse relationship and access to education that can improve the quality of care at the hospital level may help decrease the occurrence of patient adverse events.
Accidental Falls ; Accidents, Occupational ; Adult ; Cross Infection/etiology ; Female ; Hospitals ; Humans ; Logistic Models ; Male ; Medication Errors ; Middle Aged ; Nurses/*psychology ; Odds Ratio ; Pressure Ulcer/etiology ; *Quality of Health Care ; Questionnaires

Necrotizing fasciitis, first described by Wilson in 1952, is one of the most dramatic infectious diseases which develops at the level of superficial fascia and involves the overlying dermis. Clinical diagnosis is often initially confused with cellulitis, and delay in the diagnosis and treatment is associated with high mortality in the range from 30% to 70%. Early diagnosis and prompt excision of all devitalized tissue are critical because any remaining necrotic tissue will continue the rapidly progressive infectious process. We, herein, report a 64-year-old man who was presented with a typical clinical course of necrotizing fasciitis.
Cellulitis ; Communicable Diseases ; Dermis ; Diagnosis ; Early Diagnosis ; Fasciitis, Necrotizing* ; Humans ; Middle Aged ; Mortality ; Subcutaneous Tissue

No abstract available.
Adenocarcinoma, Papillary* ; Thyroid Gland*

Spontaneous rupture of intrahepatic cholangiocarcinoma is rare due to its abundant fibrous stroma. We report our experience in a case of spontaneous rupture of intrahepatic cholangiocarcinoma in a pregnant patient. In our case, multiple hepatic masses with intratumoral hemorrhage were noted on post-delivery computed tomography and magnetic resonance imaging and they caused hemoperitoneum. A right hemi-hepatectomy was carried out to control the bleeding and the diagnosis of intrahepatic cholangiocarcinoma with metastasis was performed.
Bile Ducts, Intrahepatic ; Cholangiocarcinoma* ; Diagnosis ; Hemoperitoneum ; Hemorrhage ; Humans ; Magnetic Resonance Imaging ; Neoplasm Metastasis ; Pregnancy ; Rupture ; Rupture, Spontaneous*

The treatment of choice for post-intubation tracheal stenosis is partial tracheal resection and end-to-end anastomosis. The surgical treatment of tracheal restenosis that results from unsuccessful repair of post-intubation tracheal stenosis is not easy. Failed reoperation results in permanent tracheostomy and loss of voice. If the first operation fails, about 4~6 months of period for resolution of inflammatory reaction, edema, and fibrosis is needed. The exact evaluation of the patient's status is necessary and success rate of reoperation for the appropriate candidates is over 90%. We report the results of treatment in two cases of tracheal restenosis that resulted from unsuccessful repair of post-intubation tracheal stenosis with review of literatures.
Edema ; Fibrosis ; Reoperation ; Tracheal Stenosis* ; Tracheostomy ; Voice

This study was developed and validated for the determination of oxyclozanide residue concentrations in beef and commercial milk, using high-performance liquid chromatography system. Oxyclozanide was successfully separated on a reverse phase column (Xbridge-C18, 4.6x250 mm, 5 microm) with a mobile phase composed of acetonitrile and 0.1% phosphoric acid (60:40, v/v%). This analytical procedure involved a deproteinization process using acetonitrile for beef and 2% formic acid in acetonitrile for commercial milk, dehydration by adding sodium sulfate to the liquid analytical sample, and a defatting process using n-hexane; after these steps, the extract was exposed to a stream of nitrogen dryness. The final extracted sample was dissolved in the mobile phase and filtered using a 0.45 microm syringe filter. This method had good selectivity and recovery (70.70+/-7.90-110.79+/-14.95%) from the matrices. The LOQs ranged from 9.7 to 9.8 microg/kg for beef and commercial milk. The recoveries met the standards set by the CODEX guideline.
Acetonitriles ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Dehydration ; Formates ; Milk ; Nitrogen ; Oxyclozanide ; Phosphoric Acids ; Rivers ; Sodium ; Sulfates ; Syringes

Erythromelalgia is an extraordinary condition of unknown etiology characterized by recurrent attacks of burning pain, redness, swelling, and warmth of the extremities. Characteristically the symptoms are provoked by heat, exercise, and dependency. Several classifications of erythromelalgia have been documented and include an erythromelalgia associated with thrombocythemia, primary erythermalgia, and secondary erythermalgia. Secondary erythermalgia develops in association with certain diseases or as a consequence of adverse drug reactions. So treat the underlying disease or withdrawal the offending drug leads to resolution of these symptoms. But primary erythermalgia occurs in the absence of any underlying disorder and is refractory to pharmacologic measures.We present a 28-year-old woman with primary erythermalgia who had recurrent episodes of severe burning pain on her feet. The pain did not respond to analgesics but relieved by immersion in cold water. The results of clinical, laboratory, and electrophysiologic investigations showed no underlying disorder. She was treated with aspirin and morphine, but it provided minimal relief only.
Adult ; Analgesics ; Aspirin ; Burns ; Classification ; Drug-Related Side Effects and Adverse Reactions ; Erythromelalgia* ; Extremities ; Female ; Foot ; Hot Temperature ; Humans ; Immersion ; Morphine ; Thrombocythemia, Essential ; Water

The editorial department of Journal of Korean Neurosurgical Society(JKNS) polled more than 1,210 members of the Korean Neurosurgical Society(KNS) to evaluate the present status of JKNS from a viewpoint of readers or authors. The survey form includes questions about the impressions and opinions of JKNS regarding to its contents, style, and service. The responses were collected by means of e-mail and a total of 107 replies could be gathered during 2 months. Analysis of the responses revealed that majority of members of the KNS recognized the efforts to improve the quality of JKNS during recent years. However, there was also apprehensions and discontent about the quality of articles and review process in some KNS members.
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