[Objective]Based on the traditional Chinese medicine theory of"spleen aversion to dampness",to investigate the role of Akkermansia muciniphila(AKK)in the construction and regulation of intestinal mucus barrier,as well as the application of traditional Chinese medicine(TCM)in the treatment of AKK-related intestinal diseases.[Methods]Based on the regulatory mechanism of AKK on the intestinal mucus barrier,this paper expounds the understanding of TCM on the intestinal mucus barrier,analyzes the relationship between AKK and the"spleen"according to the theory of"spleen aversion to dampness",and discusses the treatment ideas of TCM for AKK-related intestinal diseases.[Results]AKK plays an important role in the construction of the intestinal mucous barrier,reflecting the characteristics of"spleen is damp soil"in the physiological state.It can increase the thickness of the intestinal mucous layer and enhance the integrity of intestinal epithelial cells through the degradation of mucin and participation in cell communication.In the pathological state,the bacterial disorder caused by"spleen deficiency and dampness"leads to the reduction of AKK,which in turn causes damage to the intestinal mucous barrier.Traditional Chinese medicine can regulate AKK by"Thickening the intestine"method to strengthen the Spleen,thereby restoring the steady-state relationship between the intestinal flora and the intestinal mucous barrier.[Conclusion]AKK plays an important role in the construction and regulation of the intestinal mucus barrier,and TCM has potential in the treatment of related intestinal diseases.However,more research is needed to confirm its pharmacodynamic mechanism.