1.Endovascular interventional treatment of bronchial artery aneurysm: case report and review of literature
Wei CHEN ; Xiaoyun HU ; Xuan WANG ; Jiasheng HUANG ; Chuanxian HU
Chinese Journal of Thoracic and Cardiovascular Surgery 2010;26(5):340-342
Objective To present one case of bronchial artery aneurysm successfully treated with endovascular interventional procedure and review literature. Methods A 67-year-old man was diagnosed with mediastinal bronchial artery aneurysm accompanied with tuberculous pleurisy by chest imaging. The aneurysm was treated via transcatheter bronchial artery embolization combined with endovascular stent-graft placement in the thoracic aorta under DSA guidance. Results Postprocedural angiography showed satisfactory exclusion of the aneurysm and no endolead. Conclusion Interventional therapeutic management of bronchial artery aneurysm is feasible and accurate.
2.Differentially expressed mRNAs and their upstream miR-491-5p in patients with coronary atherosclerosis as well as the function of miR-491-5p in vascular smooth muscle cells
Hui DING ; Quanhua PAN ; Long QIAN ; Chuanxian HU
The Korean Journal of Physiology and Pharmacology 2022;26(3):183-193
MicroRNAs (miRNAs) regulate gene expression and are biomarkers for coronary atherosclerosis (AS). A novel miRNA-mRNA regulation network of coronary AS still needs to be disclosed. The aim of this study was to analyze potential mRNAs in coronary AS patients and the role of their upstream miR-491-5p in vascular smooth muscle cells (VSMCs). We first confirmed top ten mRNAs according to the analysis from Gene Expression Omnibus database (GSE132651) and examined the expression levels of them in the plaques and serum from AS patients. Five mRNAs (UBE2G2, SLC16A3, POLR2C, PNO1, and AMDHD2) presented significantly abnormal expression in both plaques and serum from AS patients, compared with that in the control groups.Subsequently, they were predicted to be targeted by 11 miRNAs by bioinformatics analysis. Among all the potential upstream miRNAs, only miR-491-5p was abnormally expressed in the plaques and serum from AS patients. Notably, miR-491-5p overexpression inhibited viability and migration, and significantly increased the expression of contractile markers (α-SMA, calponin, SM22α, and smoothelin) in VSMCs. While silencing miR-491-5p promoted viability and migration, and significantly suppressed the expression of α-SMA, calponin, SM22α, and smoothelin. Overall, miR-491-5p targeted UBE2G2, SLC16A3, and PNO1 and regulated the dysfunctions in VSMCs.
3.Relationship between heart rate and failure of biological valve: slowing the heart rate could delay the failure of biological valve?
Qiuxia SHI ; Chuanxian HU ; Xiaotong HOU ; Ming JIA ; Zhiwei XU ; Jinsheng XIE
Chinese Medical Journal 2014;127(8):1588-1589
Aged
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Aortic Valve
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physiology
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Female
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Heart Rate
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physiology
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Humans
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Male
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Middle Aged
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Retrospective Studies