OBJECTIVE: To develop a set of consummated comprehensive application platform that meets the actual demand so as to promote hospital treatment level and pharmaceutical care quality.METHODS: The protocol and standard meeting the international standard was adopted for system design.The currently popular combination tools(Apache+PHP+MySQL) set was developed and an open information resources management system and multi-structured architecture were established.RESULTS & CONCLUSIONS: This system is practical,advanced and safe and it is composed of 5 modules: drug inquiry system,rational drug use system,management on adverse drug reactions,pharmacy administrative management and network management.The system can not only guarantee the compatibility and the expandability of system,but also meet the needs of the development of hospital pharmacy and effectively enhance the rational drug use.

The whole pharmaceutical care package was given by clinical pharmacist to a patient with infective endocarditis and renal insufficiency .The pharmacist performed pharmaceutical care by analyzing the condition of the patient ,evaluating and making treat-ment plan and adjusting the drug dosage .With the cooperation of clinical pharmacist ,the doctor optimized the treatment plan to individ-ualize treatment ,and ensured the effectiveness and safety of medications .

Objective: To understand the relationship between childhood abuse and social anxiety and its influencing factors,so as to provide a theoretical basis for the intervention targeting social anxiety in adolescents. Methods: The Metaanalysis was conducted on the 30 selected articles using randomeffects models, comprising 93 independent effect sizes and a total sample of 19 354. Odds ratio (OR) was used to integrate the relationship between childhood abuse and social anxiety. Results: There was a significant positive correlation between childhood abuse and social anxiety (r=0.22), and its subtypes (emotional abuse, emotional neglect, emotional maltreatment, physical abuse, physical neglect, sexual abuse) could also positively predict social anxiety (OR=3.14,1.97,2.42,1.78,1.68,1.54)(P<0.01). The moderating effect showed that cultural background could significantly moderate the relationship between emotional neglect and the composite index and social anxiety (Qb=3.95,3.93), and the relationship between emotional abuse and composite index and social anxiety were significantly moderated by age (Qb=7.65,8.72)(P<0.05). Conclusions Childhood abuse is a positive predictor of social anxiety. Cultural background and age have a significant moderating effect on the relationship between childhood abuse and social anxiety, but gender has no significant moderating effect.

OBJECTIVE To explore the clinical efficacy of clarithromycin sustained-release tablets in the primary eradication of Helicobacter pylori. METHODS Retrospective analysis of the data of patients with primary eradication of Helicobacter pylori admitted to the outpatient department of Tongde Hospital of Zhejiang Province from January 2019 to December 2020 was conducted. They were divided into three groups according to the choice of clarithromycin dosage form and dosage, namely, clarithromycin tablets 500 mg bid treatment group(group A), clarithromycin sustained-release tablets 500 mg bid treatment group(group B), and clarithromycin sustained-release tablets 500 mg qd treatment group(group C). At least 4 weeks after the end of treatment in each group, telephone follow-up was conducted to compare and analyze the efficacy, compliance, recurrence rate, incidence of adverse reactions, and cost effectiveness ratio of different treatment schemes for eradication. RESULTS After eliminating lost visits, a total of 350 cases were included in this study, including 132 cases in group A, 101 cases in group B, and 117 cases in group C. The overall eradication rates in each group were 95.45%, 92.08%, and 97.44%, respectively. Six patients with low compliance were excluded (3 in group A, 3 in group B, and 0 in group C), with eradication rates of 95.35%, 92.86%, and 97.44%, respectively. There was no significant difference in the eradication rate, compliance, recurrence rate, and incidence of adverse reactions among the groups, but the cost effectiveness ratio in group C was the lowest. Taking group A as a reference, the incremental cost effectiveness ratio for group C was ‒156.459. CONCLUSION Clarithromycin sustained-release tablets can be safely and effectively used in the primary eradication treatment of patients with Helicobacter pylori infection, and can be used according to the recommended dosage in the instructions.