Objective To analyze the outputof hotliteratures on pharmacology & toxicology in the world .Methods Es-sential Science Indicators Database were retrievedandthe national distribution ,published journals and hot research topics of hot literatures were analyzed .Results There were 76 papers in ESI on pharmacology & toxicology ,which were publishedin 22 countries or regions ,involved 5 hot research topics .Conclusion The influence of hot literatures on pharmacology & toxicology from China was behind European and American countries .Chinese journals should focus on the hot research on pharmacological& toxicology and improve the influence and scope of journals .