Objective:To evaluate the effect of modified Tianma-Gouteng Decoction combined with conventional western medicine in the treatment of cerebral hemorrhage with syndrome of hyperactive liver yang causing wind. Methods:From May 2017 to December 2019, 120 patients of cerebral hemorrhage with syndrome of hyperactive liver yang causing wind were randomly divided into two groups, 60 in each group. The control group was treated with conventional western medicine treatment, and the observation group was with modified Tianma-Gouteng Decoction on the basis of the control group. Before and after treatment, the TCM symptom scores were evaluated. Serum norepinephrine (NE), epinephrine (E), dopamine (DA) were detected by ELISA. Serum MDA was detected by ELISA. Serum homocysteine (Hcy), endothelin (ET) were detected by fluorescence polarization immunoassay, the National Institutes of Health Stroke Scale (NIHSS) was used to assess the degree of neurological impairment, and Barthel index was used to assess activities of daily living. The rebleeding during the treatment was observed and recorded to evaluate the clinical efficacy. Results:The total effective rate was 90.0% (54/60) in the observation group and 70.0% (42/60) in the control group, with significant difference between the two groups ( χ2=7.500, P=0.006). After 3 and 6 weeks of treatment, the TCM syndrome score of the observation group were significantly lower than those in the control group ( t=10.670, 14.022, P<0.001). After treatment, NIHSS score of treatment group was significantly lower than that of control group ( t=5.736, P<0.01), Barthel index score of treatment group was significantly higher than that of control group ( t=10.559, P<0.01). After treatment, serum NE [(2 897.51 ± 241.65) pmol/L vs. (6 309.25±394.16) pmol/L, t=57.160], E [(1 352.45 ± 234.15) pmol/L vs. (4 131.20 ± 431.55) pmol/L, t=43.839] and DA [(623.59 ± 45.61) pmol/L vs. (950.61 ± 51.39) pmol/L, t=36.866] levels, serum SOD [(4.08 ± 1.05) C/μg·mgHb vs. (3.16 ± 1.02) C/μg·mgHb, t=4.868], MDA [(3.15 ± 1.41) μmol/L vs. (5.86 ± 1.31) μmol/L, t=10.907] levels, serum Hcy [(12.98 ± 2.41) μmol/L vs. (17.68 ± 2.26) μmol/L, t=11.019], ET [(51.36 ± 5.29) ng/L vs. (79.58±7.65) ng/L, t=23.502] in treatment group were significantly lower than those in the control group ( P<0.01); NO [(63.19 ± 3.87) μmol/L vs. (51.26 ± 3.59) μmol/L, t=17.506] in treatment group was significantly higher than that of the control group ( P<0.01). The incidence of rebleeding was 1.7% (1/60) in the observation group and 15.0% (9/60) in the control group, where the difference was statistically significant ( χ2=6.982, P=0.008). Conclusion:Modified Tianma-Gouteng Decoction combined with conventional western medicine therapy can protect the cerebral nerve function of patients with cerebral hemorrhage with syndrome of hyperactive liver yang causing wind, prevent the secondary ischemic brain injury after cerebral hemorrhage, and improve the clinical curative effect.

Objective Different grades of glioma lead to different clinical course,treatments and prognosis,thus it is important to predict histological grades of glioma preoperatively.18F-FDG PET/CT imaging and MR perfusion imaging is considered a promising method to evaluate glioma,and the present study was to evaluated the contribution of 18F-FDG PET/CT imaging and MR perfusion imaging in grading intracranial glioma.Methods Eighteen consecutive patients with suspected primary brain glioma underwent 18F-FDG PET/CT scanning and MR perfusion scanning in our hospital.To evaluate the relative sensitivity among standardized uptake value (SUV),L/W,and rCBV,the PET/CT imaging were analyzed,and the SUV and Lesion-to-white matter ratio (L/W) were calculated.The rCBV ratios of lesions were calculated relative to the region of interest (ROI) values in contra lateral normal white matter.Results Eighteen brain gliomas were confirmed by pathologic diagnosis,including 7 WHOⅡ tumors,6 WHOⅢ tumors,and 5 WHOⅣ tumors.SUV and rCBV could not differentiate between WHOⅡ tumor and WHOⅢ tumor,however significant difference could be found among the three using L/W.Conclusion 18F-FDG PET/CT imaging and MR perfusion imaging could offer more diagnostic information than conventional MRI.All of the three semiquantitative data offer some contribution in grading intracranial gliomas,and L/W might be the best one.

Objective: To investigate the mutual prediction relationship between peer relationship and internalizing problem. Methods: One-year follow up survey was conducted with a sample of 220 preschool children from 4 kindergartens in Shandong province. The quality of peer relationship and degree of internalizing problem were evaluated with the Peer Relationship Scale and the Child Behavior Checklist Cross-lagged panel analysis was used for mutual prediction among variables. Results: The quality of preschool children’s peer relationship showed an increasing trend with grade(F=6.40, 4.81, P<0.01), while the degree of internalizing problem showed a downward trend(F=7.65, 5.46, P<0.01). The predictive effect of pre-test peer relationship and internalizing problem on post-test corresponding behaviors were all statistically significant (β=0.56, 0.49, P<0.01). The predictive effect of pre-test peer relationship on post-test internalizing problem was statistically significant(β=-0.19, P<0.05). Conclusion Both peer relationship and internalizing problem has a certain stability across time, and early peer relationship and internalizing problem could predict later corresponding behaviors. Early peer relationship can predict later internalizing problem, while early internalizing problem cannot predict later peer relationship.

Objective To investigate the biodistribution of 18F-Alfatide II in patients with breast diseases and to compare its uptake with 18F-fluorodeoxyglucose(FDG)uptake.Methods A total of 44 female patients(age:(50.7±8.0)years)with clinically suspected breast cancer from December 2015 to May 2017 were prospectively enrolled and underwent 18 F-Alfatide II and 18F-FDG PET/CT prior to treatment.By drawing regions of interest in normal organs and breast lesions,differences between 18F-Alfatide II uptake and l8F-FDG uptake were evaluated in all patients.Paired t test,two-sample t test and Wilcoxon rank sum test were used for data analysis.Results There were 53 breast lesions confirmed by histopathology in 44 patients.Among them,42 lesions were malignant and the others were benign.The uptake of 18F-Alfatide II was very low in the brain,vocal cords,lungs,blood pool and muscle.But the renal cortex and bladder had high 18F-Alfatide II accumulation.Different levels of 18F-Alfatide II uptake were found in other normal organs including normal breast tissue.There were differences(t values:2.04-41.65,all P<0.05)between 18F-Alfatide II and 18F-FDG maximum standardized uptake value(SUVmax)and mean standardized uptake value(SUVmean)in many normal organs except for the choroid plexus,salivary glands,liver,colon and normal breast tissue.The uptake of 18F-Alfatide II was significantly lower than 18F-FDG in breast cancer lesions(SUVmax:3.77±1.78 vs 7.37±4.48,SUVmean:2.25±0.98 vs 4.54±2,82;t values:4.89,4.82,both P< 0.05),but it was still higher in benign breast lesions(SUVmax:2.37±1.62,SUVmean:1.50±0.92;t val-ues:2.35,2.29,both P<0.05).Also,target/non-target(T/NT)of 18F-Alfatide II in breast cancer lesions was higher than that in benign breast lesions(5.32±3.08 vs 2.60±2.37;t = 2.72,P<0.05).Condusion The biodistribution of 18F-Alfatide II in patients is favorable and 18F-Alfatide II can be clinically used for breast cancer imaging.