Objective To investigate the role of miR-203 in radiation-induced thymic lymphoma (RITL).Methods A 60Co irradiator was used for total-body irradiation.MicroRNAs(miRNAs) level was assayed by qRT-PCR.Cell proliferation was assayed by MTT assay.Cell apoptosis was examined by fluorescence activated cell sorter (FACS).Dual luciferase reporter assay system was used to detect the 3'UTR reporter.Results MiR-203 was down-regulated in RITL tissues.Overexpression of miR-203 strongly inhibited the proliferation of both NIH3T3 cells and EL4 cells and vice versa.MiR-203 inhibited cells proliferation and induced apoptosis via TANK-binding kinase (TBK1),SLUG (SNAI2) and Cyclin D1 (CCND1).Conclusions Radiation down-regulated the level of miR-203 in thymic,which promoted radiation-induced thymic lymphoma by targeting TBK1,SNAI2 and CCND1.

Objective: To investigate the effect of progressive early rehabilitation training in patients with severe acute pancreatitis. Methods: A total of 67 patients with severe acute pancreatitis requiring mechanical ventilation who were treated in the intensive care department of Shanghai first people's hospital from May 2015 to May 2018 were selected. According to the order of admission, they were divided into the control group (n=32) and the intervention group (n=35). On the basis of this nursing, the intervention group was jointly evaluated by the ICU rehabilitation team and adopted the progressive early rehabilitation nursing mode according to the different degrees of patients' conditions. The intervention effects of the two groups were compared. Results: The success rate of one-time weaning, mechanical ventilation time and ICU hospitalization time in the intervention group were 97.14% (34/35), (4.62±1.98) d, (8.76±1.02) d, and 78.12% (25/30), (9.01±2.15) d, and (14.01±2.87) d, respectively, in the control group. The difference between the two groups was statistically significant (χ² = 3.986, t=-5.012, -8.260, P < 0.05 or 0.01). The incidence of delirium, Barthel index (BI) scale score and grip strength score were 2.86% (1/35), 47.54±4.32, (34.05±10.68) kg, in the intervention group, 12.50% (4/32), 41.68±3.18, and (26.79±8.97) kg, in the control group, respectively. The difference between the two groups was statistically significant (χ²=4.024, t=7.651, 3.194, P < 0.05 or 0.01). Conclusions Progressive early rehabilitation training and nursing has a great influence on the prognosis of patients with severe acute pancreatitis, which can effectively improve the prognosis of patients, accelerate the recovery of patients, shorten the length of hospital stay and the duration of use of ventilator, reduce the incidence of delirium, help patients to restore muscle strength, and improve the Barthel index score of patients, which is worthy of promotion and application.