2.Efficacy of Lugua polypeptide injection on active rheumatoid arthritis.
Sheng-yu GUO ; Lian-jie LIN ; Hua CHU ; Chuan YANG ; Dan-dan GONG ; Jia TIAN ; Hai-xiang FU
China Journal of Orthopaedics and Traumatology 2008;21(8):610-612
OBJECTIVETo investigate the therapeutic effect of Lugua polypeptide on active rheumatoid arthritis (RA).
METHODSFifty patients with active RA were selected for the study and were randomly divided into study group and control group. Patients in study group were treated with Lugua polypeptide intravenously at a dose of 16 mg per day and those in control group were given Celecoxib 200 mg twice a day for successive 2 weeks. Two groups were given the same basic treatment. Tenderness and swelling of joints, morning stiffness, erythrocyte sedimentation rate, C-reactive protein,rheumatoid factor and so on were recorded before and after treatment.
RESULTSThe above index on joints in study group was significantly improved compared with that in control group and the level before treament. No apparent side effects were observed.
CONCLUSIONLugua polypeptide is effective and safe on active RA. It is a promising agent in the treatment of RA.
Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal ; administration & dosage ; Arthritis, Rheumatoid ; drug therapy ; Female ; Humans ; Injections ; Male ; Middle Aged ; Peptides ; administration & dosage
3.Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice.
Chen CHU ; Lu YU ; Joelle HENRY-BERGER ; Yan-Fei RU ; Ayhan KOCER ; Alexandre CHAMPROUX ; Zhi-Tong LI ; Miao HE ; Sheng-Song XIE ; Wu-Bin MA ; Min-Jie NI ; Zi-Mei NI ; Yun-Li GUO ; Zhao-Liang FEI ; Lan-Tao GOU ; Qiang LIU ; Samanta SHARMA ; Yu ZHOU ; Mo-Fang LIU ; Charlie Degui CHEN ; Andrew L EAMENS ; Brett NIXON ; Yu-Chuan ZHOU ; Joël R DREVET ; Yong-Lian ZHANG
Asian Journal of Andrology 2020;22(6):590-601
The mammalian epididymis not only plays a fundamental role in the maturation of spermatozoa, but also provides protection against various stressors. The foremost among these is the threat posed by oxidative stress, which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids, proteins, and nucleic acids. In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5) as a major luminal scavenger in the proximal caput epididymidal segment. Accordingly, the loss of GPX5-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx5
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