Objective To preliminary evaluate the efficacy and safety of Lev therapy in infant with epilepsy .Methods To chil-dren with infant epilepsy in the Department of Neurology of Chongqing Children′s Hospital from May 2010 to February 2012 were enrolled .All of them took Lev mono-therapy or adjunctive therapy .Investigation was done by self-controlled and retrospective re-search .There were 70 patients received Lev therapy ,aging from one month to one year old ,and 39 patients received mono-therapy , 31 patients received adjunctive therapy .All subjects were divided into 2 groups ,12 patients in partial seizure group and 58 patients in generalized seizure group .Then all patients took a 7 months Lev therapy after initial medication .The seizure frequency change , seizure situation ,side effect were observed .Results During the follow-up ,5 patients lost their follow-up(3 case in mono-therapy group ,2 case in adjunctive therapy group)and 3 patients died .In mono-therapy group ,83 .33% of patients got responder and 16 . 67% of patients unmodified or worsen ,while those in adjunctive therapy group were 58 .62% and 41 .38% ,respectively .And there was significant difference between two groups(P<0 .05) .In the partial seizure group ,81 .81% of patients got responder and the 18 .18% of patients unmodified or worsen ,while those in generalized seizure group were 70 .37% and 29 .63% .And there was no significant difference between partial and generalized seizure group(P>0 .05) .During the study ,22 patients ended Lev therapy for some reasons .77 .27% of patients discontinued in 1-6 months and 22 .73% of patients in 7-34 months .Number of the adverse reac-tions was 14 .Main adverse reactions observed were anorexia and sleep disorders in early .3(4 .61% )of 65 patients discontinued ther-apies for the adverse reaction ,but there was no death caused by adverse reaction .Conclusion The Lev mono-therapy and adjunctive therapy are both effective in infant with epilepsy ,and Lev therapy is effective in infant epilepsy .

Objective To investigate the morbidity and influencing infactors of plantar fasciitis in nurses. Methods The clinical nursing staff of 829 people were included in this series. 71 people of them conform to the standard of plantar fasciitis. According to the proportion of 1:1, 71 nurses without plantar fasciitis were included in the control group. The thickness and hardness index of the plantar fascia were detected by ultrasound elasticity. The survey contents including age, the average working hours every day (h), the average standing time in working day (h), body weight, body mass index (BMI), number of night shift, average walking time every day (min) and the average weekly running time (hour) were conducted. The single factor and multi-factor regression method were used to analyze the influence factors of the onset of plantar fascia. Results 71 cases of 829 nurses were with plantar fasciitis, and the incidence was 8.56%. The thickness in observation group was (3.86±0.53) mm, which was significantly smaller than (2.67±0.39) mm of the control group (P<0.05). Hardness index was 2.01±0.23, lower than 3.83±0.70 in control group (t=14.09, P<0.05). Single factor analysis results showed that the average standing time in working day, weight, BMI, average walking time every day, the average weekly running time were different between the two groups (P<0.05). The regression equation: the plantar fascia hardness index =-25.34 + 4.78 × the average standing time in working day + 3.45 × weight + 1.22 × BMI. The equation of the ability to explain the plantar fascia hardness index reached 72.2%, and had a good effectiveness. Conclusions Body weight and BMI, prolonged standing work may induce the nurse plantar fasciitis, and they are independent risk factors.

Objective To find out the defects existing in the rinsing and sterilizing process of the automatic bottle washer and to put forward an improvement measure and efficiency assessment.Methods To make the washer more effective,an automatic brush pre-washing process and a rotary spraying device were designed and used.The total bacteria amount,the total coliform group and the disinfectant (ClO2) residual level were employed as the assessment parameters.Results An external automatic pre-washing machine was installed on the bottle washer;the bottle washer was innovated so that its spray nozzle could be in directions and the rinsing and sterilizing process could be enhanced.The results showed that the improved machine ran well in treating the polluted and recycled bottles and all the assessment indexes were better than that of before improvement.Conclusion The improved automatic bottle washer is considered effective in cleanout and sterilization of bottles with a satisfactory result.

OBJECTIVETo observe the effect of Tetramethyl pyrazine (TMP) on the cytokines and inflammatory mediators in the serum and the synovial fluid of collagen-induced arthritis (CIA)rats, and further to investigate its possible mechanisms for treating rheumatoid arthritis (RA).

METHODSType II CIA rat model was established. Rats in the TMP group were administered with TMP at 50 mg/kg and 100 mg/kg, once daily. Dexamethasone at 2.0 mg/kg was intramuscularly injected to those in the Dexamethasone treated group, once daily. Normal saline at 2 mL/kg was given to those in the normal control group and the model group, once daily. All medication was started from the 7th day, lasting to the 35th day. CIA rats' foot swelling degree was observed. Contents of serum IL-1, IL-6, IL-2, NO and PGE2in the synovial fluid were detected by radioimmunoassay and nitrate reduction method.

RESULTSCompared with the normal group, the foot swelling obviously increased, contents of NO and PGE2 in the synovial fluid were obviously elevated in the model group (P < 0.01). Compared with the model group, the foot swelling could be obviously inhibited by 100 mg/kg TMP and Dexamethasone; serum levels of IL-1 and IL-6 obviously decreased, serum IL-2 level obviously increased, contents of NO and PGE, decreased (P < 0.01). TMP 50 mg/kg could obviously inhibit the foot swelling of CIA rats (P < 0.01). There was no statistical difference in other indices (P > 0.05).

CONCLUSIONSTMP at 100 mg/kg showed obvious inhibition on CIA rats. Its inhibitory effect might be correlated to inhibiting activities of endogenous cytokines and the generation of inflammatory mediators in inflammation local regions, improving contents of anti-inflammation cytokines, and inducing the balance of the inflammatory cytokine network.

Animals ; Arthritis, Experimental ; blood ; metabolism ; Dinoprostone ; metabolism ; Female ; Interleukin-1beta ; blood ; Interleukin-2 ; blood ; Interleukin-6 ; blood ; Male ; Nitric Oxide ; metabolism ; Pyrazines ; pharmacology ; Rats ; Rats, Sprague-Dawley ; Synovial Fluid ; metabolism

Aged ; Aged, 80 and over ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Otorhinolaryngologic Diseases ; therapy ; Retrospective Studies

The morbidity of deep vein thrombosis (DVT) after total hip replacement,total knee replacement or hip fractures surgery is high,and there is no effect way to prevent.Rivaroxaban is an oral,direct factor Xa inhibitor.The prevention effect of rivaroxaban to DVT after orthopedic surgery is stronger than enoxaparin.The view summarizes the mechanism,pharmacokinetics,interaction of drugs and the antithrombotic effect after orthopedic surgery.

IgA nephropathy is the most common primary glomerular disease in China without any specific treat-ment. Corresponding treatments are usually adopted according to different clinical types. Referred to the clinical classification principles and the experiences of his own, Professor Huang Chunlin presented traditional Chinese medicine (TCM) medication experiences for different clinical types of IgA nephropathy which had some clinical instructive significance .

This paper summarized Professor Huang Chunlin's traditional Chinese medicine (TCM) medication expe-riences for patients with hypoalbuminemia in refractory nephrotic syndrome (RNS). This paper was divided into three parts. The first part was the overview of hypoalbuminemia in RNS. The second part was the TCM medica-tion experiences for patients with hypoalbuminemia in RNS which included the integrated application of tonifying the spleen, nourishing the liver and reinforcing the kidney. The third part was the explanation of the comprehen-sive application of Professor Huang Chunlin's TCM medication experiences for patients with hypoalbuminemia in RNS through the introduction of a typical case. TCM medication experiences for RNS treatment based on experi-ences of famous TCM doctors provided theoretical and practical basis for therapeutic regimen.

Cell smears were made from fresh mammary tissue during operation. There are 32 samples with definite pathological diagnosis. DNA content was measured in interphase nuclei of single epithelial cells of lesions of the human breast by a microspectrophotometric technique. The normal lymphocytes from 2 cases of normal blood samples and from 4 cases of mammalopathic tissue were used as a reference for the DNA value corresponding to a diploid number of chromosomes. The normal lymphocyte had mean DNA value in 11.2?0.2 A.U. and 10.9?1.3 A.U. The rest of the measurements showed: 12.1?1.3 A.U. in the, epithelial nuclei of 10 cases of neighbouring mammalopathic tissue; 22.6?1.0 A.U. in 9 cases of fibrcma of the breast; 31.9?2.3 A.U. in 8 cases of carcinomas of the breast. The cell nuclei of carcinomas showed abnormal DNA values and the multiploid cells were dominant. It's histograms showed a shift to right and either a double-peak or multiploid-peak distribution. The DNA contents of the benign lesion cells were significantly lower than that of cancer cells, but higher than that of normal cells. The peak of their histogram showed they are between 2C-4C.

Polymorphism, Genetic ; Gene Frequency ; China ; Genetics, Population ; Microsatellite Repeats/genetics*