The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements tocompare, But there are several difficulites in the way of knowledge of the sensitivity and reaction of the liverto radiation. Perhaps the most important is the regenerative abillity of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necrosis of the liverin man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in resum enezymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The resuls obtained are asfollows; 1. Serum SGOT activities were significatnly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltration, loss of intra cytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.
Alanine Transaminase ; Aspartate Aminotransferases ; Cytoplasm ; Epithelium ; Glycogen ; Hepatitis ; Hepatocytes ; Liver ; Necrosis ; Radiation Injuries ; Skin ; Stomach

Osteoarthritic changes in experimental animals has been induced by several different methods. In order to study the changes of the articular cartilage induced by injuries of ligaments and/or meniscus of the knee joints, the author performed the experimental study that section of the medial collateral and anterior cruciate ligaments (group I) and section of the medial collateral and anterior cruciate ligaments combined with excision of the medial meniscus (group II) in twenty adult rabbit's knees caused instability. Histological changes of the articular cartilage were observed up to four months. The results were as follows: 1. The changes of the articular cartilage were gradually advanced depend on the time lapse after experimental procedures, in group I and ll. 2. The changes of the articular cartilage could be noticed from eighth week after experimental procedures in group I and from fourth week in group II, and more severe at sixteenth in group I and at twelfth week in group II. 3. The changes of the articular cartilage in group ll were appeared earlier and more severe than in group l. 4. The changes of the articular cartilage in the medial side of the knee joint were noticed more severe than in the lateral side.
Adult ; Animals ; Anterior Cruciate Ligament ; Cartilage, Articular ; Humans ; Knee Joint ; Knee ; Ligaments ; Menisci, Tibial ; Rabbits

No abstract available.
Flow Cytometry* ; Humans* ; Leukocytes* ; Microscopy* ; Phagocytosis* ; Staphylococcus aureus* ; Staphylococcus*

No abstract available.
Flow Cytometry* ; Humans* ; Leukocytes* ; Microscopy* ; Phagocytosis* ; Staphylococcus aureus* ; Staphylococcus*

No abstract available.
Peritoneal Dialysis*

No abstract available.
Magnetic Resonance Imaging*

The purpose of this paper is to review the colonoscopic fingings of twenty two patients with colonic tuberculosis which were diagnosed by colonoscopic finding, histopathology, and follow-up observation after antituberculosis chemotherapy at Pusan National University Hospital from January 1992 to December 1994. The results were as follows: 1) The male to female ratio was 1: 1.2, and the average age of the patients was 39.4 years with a slight predominance in women. The age of peak incidence was the 4th decade 40.9%). 2) Abdominal pain(95%), diarrhea(63%), and weight loss(50%) were the most common clinical findings. Others were constipation, melena, and palpable abdominal mass. The location of the pain was right lower abdomen, epigastrium, central abdomen, and left lower abdomen in decreasing order. 3) Hematologic findings showed decrease in hemoglobin level, increase in ESR, and positive CRP(61.5%). The white blood cell counts were mostly normal. 4) The stool examination showed positive occult blood in 7 cases among 18 cases (38.9%). Acid-fast bacteria was observed in stool of one case. 5) On colonoscopy, the lesion sites were ileoeecal valve(75%), ascending colon(72.7 %), terminal ileum(52.6%), cecum(42.9%), transverse colon(31.8%), descending colon (27.3%), sigmoid colon(9%), and rectum(9%) in decreasing order of frequency. Most of them involved ileocecal area. 6) On colonoscopy, the shape of ulcer revealed circular(41%), fusion(36%), and irregular pattern(18%). It found skipped area in 9 cases, pseudopolyp in 8 cases, patency of ileocecal valve in 5 cases, and severe deformity of ileocecal valve in 6 cases. 7) Microscopic finding of biopsy specimens revealed noncaseating granulomatous inflammation in 12 cases, and nonspecific ulcerative inflammation in 10 cases. In conclusion the diagnostic yield may be greatly enhanced by obtaining multiple target biopsies frorn tbe deep portion of the ulcer bed and margins. Judged from the colonoscopic finding and clinical improvement after antituberculosis chemotherapy, more accurate diagnosis can be acquired.
Abdomen ; Bacteria ; Biopsy ; Busan ; Colon* ; Colon, Descending ; Colon, Sigmoid ; Colonoscopy ; Congenital Abnormalities ; Constipation ; Diagnosis ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Ileocecal Valve ; Incidence ; Inflammation ; Leukocyte Count ; Male ; Melena ; Occult Blood ; Tuberculosis* ; Ulcer

Neonatal lupus erythematous is a rare syndrome, which is characterized by a transient lupus dermatitis, hematologic abnormalities and isolated congenital heart block. We detected the atrioventricular dissociation, bradycardia and pericardial effusion by fetal echocardiography in a female fetus at 25th weeks of gestational age. The baby was born in the 38th week of pregnancy by Cesarean section with 1790 gram of body weight. In spite of atrioventricular dissociation with bradycardia and pericardial effusion, cardiac pacemaker was not needed during neonatal period because she was doing well, no evidence of congestive heart failure and around 80 beat per minute of heart rate. The serologic markers for diagnosis of neonatal lupus are the autoantibodies specific to SS-A/Ro and/or SS-B/La. These antibodies are produced by the mother and passed to the fetus through the placenta. Autoantibodies of cytoplasmic SS-A antigens or SS-B antigen were found in the blood of this patient and her mother. We report a case of neonatal lupus syndrome with congenital atrioventricular dissociation with Rt. Bundle branch block and hematologic abnormality.
Antibodies ; Autoantibodies ; Body Weight ; Bradycardia ; Bundle-Branch Block ; Cesarean Section ; Cytoplasm ; Dermatitis ; Diagnosis ; Echocardiography ; Female ; Fetus ; Gestational Age ; Heart Block* ; Heart Failure ; Heart Rate ; Heart* ; Humans ; Mothers ; Pericardial Effusion ; Placenta ; Pregnancy

Appendiceal diverticula are uncommon lesions. A retrospective study of appendiceal diverticula was done for 1379 appendectomies is performed from June 1991 to May 1996. Thirty-six cases (2.6%) of appendiceal diverticula were found. Only one case was detected operatively; the rest of them were diagnosed pathologically. These thirty-six cases have been classified into three groups: 23 cases of primary appendiceal diverticulitis, 8 of secondary appendiceal diverticulitis, and 5 of simple diverticulosis. The clinical manifestations of primary appendiceal diverticulitis were different from those of typical acute appendicitis. Primary appendiceal diverticulitis was seen mainly after the fourth decade of life. The pain came on rather insidiously and seemed to extend over a longer period. A history of previous attack was frequent. The rate of perforation in primary appendiceal diverticulitis was 78.2%.The false form of appendiceal diverticula was more common in most series. Also, no case was detected in appendectomies performed on many patients under 10 years of age with a diagnosis of appendicitis. They seemed to develop after birth and were seen frequently along the mesenteric border. The rate of mucosal hyperplasia in appendiceal diverticula was 61.1%, higher than that for appendicitis. Vascular hiatus between muscular bundles along the mesenteric side, and the mesenteric covering over the diverticula, as well as the inability of false diverticula to endure high intraluminal pressures, seem to be pathophysiologically associated with the cause and the high perforation rate in appendiceal diverticula. The clinical picture and the pathologic findings of primary appendiceal diverticulitis are definitely different from those of acute appendicitis. We suggest primary appendiceal diverticulitis be regarded as a clinical entity, not a variant of acute appendicitis. The patient with atypical right lower quadrant pain should be examined with this diagnosis in mind.
Appendectomy ; Appendicitis ; Diagnosis ; Diverticulitis* ; Diverticulum ; Humans ; Hyperplasia ; Parturition ; Retrospective Studies

Chronic postirradiation changes of skin reflect the injury of dermal structures particularly the vasculature and connective tissue. The clinical signs include atrophy, partial or complete destruc tion of cutaneous appendatges, telangiectasis, sclerosis of underlying tissue, pigrnentary changes, and in rare instances, ulceration with or without var ious premalignant and malignant neoplasms. The patient, was a 65-year-old man, who had been exposed to a large amount. of X-ray irradi- ation on his hands incidentally or accidentally for a long time. The skin changes of his hand were thickening and hardening of all digits loss or focal consttict,ion of digits, and keratotic papules. Epidermal hyperplasia and fibrous thickening of collagen bundles were found on skin biopsy. Gradual narrowingal of the bony caliber with eventual resorption was noticed on radiologic examination. It has been rarely reported in the literature that chronic radiation dermatitis develops severe and unusal manifestions such as acrosclerosis and loss of digit due to osteoradionecrosis.
Aged ; Atrophy ; Biopsy ; Collagen ; Connective Tissue ; Dermatitis* ; Hand ; Humans ; Hyperplasia ; Osteoradionecrosis* ; Sclerosis ; Skin ; Telangiectasis ; Ulcer