59 cases of pancreatic ultrasonography, proven by clinically, radiologically or pathologically, were analyzedand the results are as follows; 1. Enchogenecity of pancreatic cancer was low echogenic in 27 cases, highechogenic in 2 cases and had similar echogenecity in 3 cases, compared with liver. 2. There were 10 cases of livermetastasis of pancreas malignancy and the metastasis was demonstrated in 7 cases by ultrasonography. Theechogenecity of liver metastasis was low in 6 of 7 cases. 3. In 14 cases of pesudocyst, inflammatory changes inthe portion other than pseudocyst were demonstrated in 5 cases. 4. The localized enlargement of pancreas head wasdemonstrated in 3 cases of pancreatitis of 10 cases.
Head ; Liver ; Neoplasm Metastasis ; Pancreas ; Pancreatic Diseases ; Pancreatic Neoplasms ; Pancreatitis ; Ultrasonography

Radiation exposure dose for patients during brain CT scan with General Electric C.T./T.8800 was measured using CaF. :Mn thermoluminescent dosimeter chips. The skin dose in single slice scan was 1.26±0.1 0 rad, and that in 9 slice scan was 2.06±0.16 rad. So the ratio was 1.63. The surface dose in profile along axial distance in multiple slice scan was also measured, and was found to be low at the junction of 2 slices. The lens dose in multiple slice scan was 0.27±0.05 rad , too small to induce any pathologic condition. As noted from the above data, the radiation exposure dose during CT scanning is not high compared with other radiologic examinations.
Brain ; Humans ; Radiation Exposure ; Skin ; Tomography, X-Ray Computed

To find any specific radiologic findings of skeletal metastases from hepatocellular carcinoma, we analyzed plain radiographs(n=25), CT(n=16) and MRI(n=5)of 25 patients with metastatic bony lesions from hepatocellular carcinoma. Vertebrae(17/25) and rids(16/25)were most frequently involved and 16 cases showed multiple metastases. The size of the lesions was larger than 5cm in 17 cases. Plain radiographs showed osteolytic destruction(2/25). CT(n=16) showed osteolytic destruction with an isodense expansile mass in all cases. Focal low attenuations suggesting necrosis were found in 2 cases. Calcification within the mass was not detected. MRI(n=5) showed a slight hyperintense area on T1WI and a defimte hyperintense mass on T2WI. After gadopentetate dimeglumine enhancement. The mass showed irregular enhancement. We concluded that skeletal metastatic lesions from hepatocellular carcinoma showed relatively large osteolytic destruction accompanying soft tissue mass and minimum central necrosis.
Carcinoma, Hepatocellular* ; Gadolinium DTPA ; Humans ; Necrosis ; Neoplasm Metastasis*

The study was undertaken to evaluate the radiological and microscopic findings of radiation pneumonitis. All 50 rats, which were used for the experiment, received a single dose of 2,000 rads of radiation on right lung using 60 Co teletherapy. Chest teleroentgenograms were checked weekly for 13 weeks and microscopic examination of irradiated lung were performed monthly after irradiation. The resuls obtained are summerized as follows. 1. Inroentgenologic examination, radiation pneumonitis began to appear 4 weeks after irradiation and progressed withtime intervals and began to resolve after 11 weeks. 2. Chest roentgenologic findings were pneumonic consolidation,atelectasis, and pleural effusion of irradiated right lung with compensatory hyper-inflation of left lung. 3. Inthe microscopic examination, pneumonitis appeared 2 weeks after irradiation and progressed with time intervals andbegan to resolve after 8 weeks. 4. The microscopic findings were fibrin deposit in alveoli and increased septalcellularity, vascular thickening, edema and congestion. After septal fibrosis and hyperplasia of bronchialmucosa, suggseting early regenerative change of radiation fibrosis, were noted 12 weeks after irradiation.
Animals ; Edema ; Estrogens, Conjugated (USP) ; Fibrin ; Fibrosis ; Hyperplasia ; Lung ; Pleural Effusion ; Pneumonia ; Radiation Pneumonitis ; Rats ; Thorax

The experimental study was performed to evaluate the microvascular changes in post irradiation injury of small intestine. With a total of 28 rats, 24 rats were irradiated on right upper quadrant of abdomen with a single dose of 2000 rads and each group of 4 rats were followed up in 1,2,4,5,12, and 16 weeks and remaining 4 rats were used for normal control group. Evaluation of the microvascular changes were done by observing both microangiographic and histopathologic findings in groups of each follow-up week. The results were as follows; 1. The main microangiographic findings were stretching and diffuse narrowing of vessels and extravasation of microbarium in post-irradiation 1-4 weeks, and focal narrowing and dilatation, irregular branching pattern and tortuosity of vessesl in in post-irradiation 8-16 weeks. Poor opacification of capillary network was continuously observed in all follow-up period. 2. The degree of vascular tortuosity in microangiography was consistent with the degree of vascular wall thickening in histopathology. 3. It is inferred that results in this experimental study with microangiography can be used as a guide line for further studies of post-irradiation injury of small intestine.
Abdomen ; Animals ; Capillaries ; Dilatation ; Follow-Up Studies ; Intestine, Small ; Radiation Injuries ; Rats

In 101 jaundiced patients, gray scale ultrasonography of longitudinal scan in RAO position demonstrated themeasurable extrahepatic biliary system in 73 patient; 17 cases (50%) of those with nonobstructive jaundice and 56cases (84%) of those with obstructive jaundice. The size of the internal diameter of extrahepatic biliary systemindicated that obstructive jaundice was best differentiated from non-obstructive jaundice when diameter above 7mm served as abnormal extrahepatic duct in jaundiced patients, giving sensitivity 85.5% specificity 97% anddiagnostic accuracy 89.5% by decision matrix analysis. The overall etiological diagnostic accuracy in obstructivejaundice was 40% which had higher one in choledocholithiasis and pancreas head carcinoma than other diseases. Thesonography should be imaging procedure of choice in differential diagnosis of jaundiced patients, which is simple, safe, noninvasive and has high diagnostic accuracy in differentiation between the two.
Bile Ducts, Extrahepatic ; Choledocholithiasis ; Diagnosis, Differential ; Head ; Humans ; Jaundice ; Jaundice, Obstructive ; Pancreas ; Sensitivity and Specificity ; Ultrasonography

The effect of radiation on the liver should be of unusual interest in as much as there are two highly specialized kinds of epithelium besides an important endothelial system and vascular and fibrous elements tocompare, But there are several difficulites in the way of knowledge of the sensitivity and reaction of the liverto radiation. Perhaps the most important is the regenerative abillity of the liver cells. It has been assumed that the liver as an organ is relatively resistant to radiation injury. Yet there are reports of necrosis of the liverin man resulting from doses of radiation which have not caused a skin reaction or any demonstrable effect on the stomach. The author made an experiment to elucidate more clearly the changes in resum enezymes and histopathology of rat's liver following irradiation to the liver with a single dose of 2,000 rads. The resuls obtained are asfollows; 1. Serum SGOT activities were significatnly elevated, 1 and 2 weeks after irradiation, and normalized after 4 weeks. 2. Serum SGPT activities were significantly elevated 2 weeks after irradiation, and normalized after4 weeks. 3. Alakline phosphatase activity were significantly elevated 1, 2 and 4 weeks after irradiation, and normalized after 8 weeks. 4. Histopathologic changes were focal necrosis, inflammatory cell infiltration, loss of intra cytoplasmic glycogen particles, and vacuolar degenerations of hepatocytes. It appeared marked 2 weeks after irradiation, restored after 4 weeks, and normalized after 8 weeks.
Alanine Transaminase ; Aspartate Aminotransferases ; Cytoplasm ; Epithelium ; Glycogen ; Hepatitis ; Hepatocytes ; Liver ; Necrosis ; Radiation Injuries ; Skin ; Stomach

The study was undertaken to evaluate the protective effect of epinephrine on renal radiation injury. For theexperiment, 50 rabbits were divided into 3 groups; the first group of 9 rabbits were used to determine theavailable dosage of epinephrine as preliminary study, the second group of 18 rabbits were used to evaluate theradiation injury as radiation group, which were received a single dose of 2,000 rads of radiation on unilateralkidney using 60 Co teletherapy unit, and the third group of 23 rabbits were used to assess the radioprotective effedct of epinephrine as radiation
Epinephrine ; Fibrosis ; Kidney ; Rabbits ; Radiation Injuries ; Renal Artery ; Urinalysis ; Urography

To evaluate the radioprotective effects of 5-thio-D-glucose(5-TDG) on normal skin, an experimental study was carried out with total 140 mice, of which 30 mice were given 5-TDG followed by irradiation and 60 mice were given intraperitoneally (IP) two hours before irradiation, and the radiation doses were singly 2500, 3500 or 4500 radsrespectively. The skin changes of the irradiated right hind limb were inspected for 31 days and the skin scores were analized. The results are as follow; 1. Marked radioprotective effect was presented in the group of 5-TDG,1.5g/kg body weight, with 2500 rads irradiation. 2. Definite radioprotective effect was also revealed in the groupof 5-TDG, 1.5kg/ body weight, with 3500 rads irradiation, In the group of double dose 5-TDG, 3.0g/kg body weight, the radioprotective effect appeared to be enhanced. 3. In the group of 4500 rads irradiation with 5-TDG, 1.5g/kgbody weight, no radioprotective effect was noticed. 4. In addition to the radiosensitization effect on the hypoxiccells, the radioprotective effect of 5-TDG on the normal animal tissue suggests increased possiblility of itsclinical application.
Animals ; Body Weight ; Extremities ; Mice ; Skin

A study has been made on the skin response of mouse hind limb to radiation to evaluate the difference of skin response to superfractionation and conventional fractionation schedules, and to optimize the time interval betweenfractions and the dose per fraction in the superfractionated irradiation. 96 mouse hind limbs were dvided into 12groups and were irradiated with 10 consecutive fractions by intervals of 6, 12 or 24 hours and dose per fractionsof 400, 500, 600 or 700 rads. The skin changes of the irradiated hind limb were observed for 30 days and the skin response were analyzed. The results are as follows; 1. There was no significant difference of early skin response along the time interval, from 6 to 24 hours, up to 600 rads per fraction. 2. Mean duration to maximum skin reaction in superfractionation (15.48±2.80 days) is shorter than in conventional fractionation (18.05±3.20 days)by 2.57 days. (p<0.05). 3. Optimum time interval betwen fractions in superfractionation may be 6 hours or less. 4. Optimum dose per fraction in superfractionation may be 500 rads or less.
Animals ; Appointments and Schedules ; Extremities ; Mice ; Skin