1.Effects of the combination therapy of the West and Taditional Chineses Medicine for 59 acute appendicitis patients with postoperative diarrhea
Chinese Journal of Primary Medicine and Pharmacy 2015;22(1):111-113
Objective To find out the efficacy of the combination therapy of the West and Taditional Chineses Medicine for acute appendicitis patients with postoperative diarrhea.Methods According to the digital table,109 acute appendicitis patients with postoperative diarrhea were randomly divided into 59 cases of the treatment group and 50 cases of the control group.The control group were given with the conventional therapy and Western medicine therapy,and the treatment group were given with the Traditional Chinese Medicine based on the control group.Test results of stool specimens pathogen,the efficacy and the occurrence of adverse drug reactions were observed.Results 96 pathogens were detected in stool specimens of the two groups of patients,the four pathogens with thelargest constituent ratios were Vibrio,Shigella,Aeromonas and Proteus,and the constituent ratio were respectively 36.5 %,22.9%,18.8% and 11.5%.The remarkable effective rate and total efficiency of the treatment group was 83.1%,96.6%,respectively,which were significantly higher than 58.0%,84.0% of the control group(x2 =8.426,4.598,all P < 0.05).The incidence of adverse drug reactions of treatment group and the control group were 5.1%,6.0%,respectively,there was no significant difference between the two groups (x2 =1.028,P > 0.05).Conclusion The efficacy of the combination therapy of the West and Waditional Chineses Medicine for acute appendicitis patients with postoperative diarrhea was significant effect,and the incidence of adverse drug reactions was less.
2.Correlation of serum S100B, IL-6 and intracranial pressure in patients with severe craniocerebral injury
Haihang ZHOU ; Litao ZHANG ; Jianguo SHEN ; Zhengmin CHU ; Wenlai CHU
Chinese Journal of Biochemical Pharmaceutics 2016;36(12):180-182
Objective To investigate the correlation between serum S100B, IL-6 and intracranial pressure in patients with severe craniocerebral injury.Methods 81 cases of patients with severe brain injury in our hospital from August 2012 to April 2016 were selected,intracranial pressure was monitored immediately after admission to calculate the average daily ICP level ,and venous blood were collected after craniocerebral injury 6,12,24,48, 72 hours.Detection of serum S100B protein and IL-6 levels,and the correlation analysis with the level of intracranial pressure.Results Patients with severe craniocerebral injury S100B levels increased gradually after injury, reached the peak at 24 hours, then decreased gradually; while patients with IL-6 and intracranial pressure after injury gradually increased, the difference was statistically significant in different time points among the S100B,IL-6 and intracranial pressure levels (P<0.05).Conclusion The changes of intracranial pressure after severe craniocerebral injury were proportional to the levels of serum S100B and IL-6,S100B and IL-6 can reflect the changes of intracranial pressure,intracranial pressure changes predicted by S100B plasma concentration in 48 hours were more sensitive than those in the same concentration of IL-6.
3.Clinical and MRI Study on Pituitary Adenoma of Different Hormone-secreting Type
Shuguang CHU ; Tianzhen SHEN ; Xingrong CHEN
Journal of Practical Radiology 2001;0(09):-
Objective To assess the clinical history and MRI findings of pituitary adenoma of different hormonesecreting type.Methods We retrospectively studied 200 postoperated patients,from 1996 to 2000,who all had the preoperated MRI exams.All cases had histopathological evalutions.Both clinical presentation(age,sex,symtom,sign)and MRI findings(size,form,signal intensity,extension)were investigated.Results There was a great span of age with sixty percent owing for 35~55 years old.The male and female proportion was 1∶2 in PRL hormone-secreting pituitary adenoma.12 cases with luleinizing hormone-secreting and 2 cases with thyrotropin hormone-secreting pituitary adenoma were just male.In other types the incidences were similar in man and woman.Clinical symptom and sign present overlapping.The volume of tumor was from 0.5 cm?0.8 cm?1 cm to 6 cm?7 cm?8 cm with most multihormone adenoma's maxium dimension out of 5 cm.The signal intensity was not characteristic pre-and post-enhancement.No calcification could be seen.In term of extension,most was to suprasellar,then infrasellar,unilateral or bilateral sinus cavernous,last was to lower part of the third ventricle.Conclusion Different hormonesecreting pituitary adenomas have some speciality in clinical and MRI presentation.Although an accurate diagnosis can not be made according to it,more information have been obtained.
4.Features of brain multiple sclerosis in magnetic resonance imaging
Shuguang CHU ; Tianzhen SHEN ; Xingrong CHEN
Chinese Journal of Neurology 2001;0(03):-
Objective To obtain magnetic resonance imaging(MRI) symptoms that could be used in medical diagnosis and identification by analyzing the diverse MRI appearance of brain multiple sclerosis(MS).Methods MRI findings of 41 samples of clinically definite MS, including the numbers, distributions, sizes, and shapes of the lesions were analyzed. The symbolic characteristics and enhanced expression are also covered.Results Brain MS might happen singly and multiply, and more frequently with multiple happening. In a multiple case, 4—15 lesions were observed the most. Some samples showed with diffuse lesions which were unable to be counted accurately presenting as a “dirty-appearing white matter”. The distribution of the lesions was observed most frequently at the two sides of periventricle, and following by the subcortical, corpus callosum, and brainstem. Only two lesions were observed at cerebrum. The size of most lesions range from a few millimeters to 2 cm, accounting for about 75% of the total samples. Lesions with size above 2 cm were seen seldomly, with the biggest one of 6—7 cm. According to the shapes and symptoms, lesions might be categorized as an acute and chronic ones. The acute lesions had a shape of oval or circle, with a swelling appearance, low signal of T_1WI, and isointensity or a slightly higher signal on the circle. T_2WI showed a high signal, with different increase and showing “core+lunar” sign. This kind of lesions showed an enhancement with the circle enhancement as the most typical one, which had a complete circle or non-conplete arc shape enhancement, even the big lesions. The chronic lesion might also be divided into two categories. One was the quasi-symmetric lesion, with the distribution along two sides of periventricle and with the shape of small puncture/patch, part of them merged into the big patch; another kind of lesions was found scattered sparsely at frontal, parietal lobes and two sides of the periventricle, with small patches in shape. The chronic lesions had an appearance of shrinking, sharp edge, even signals, and had no lunar circle phenomena and obvious enhancement.Conclusion Brain MS have diverse MRI appearence, with some of which are unique and symbolic.
5.Stem cell transplantation for treating diabetic foot
Jianhua CHU ; Ruijuan SHEN ; Dalin SONG
Chinese Journal of Tissue Engineering Research 2007;0(12):-
AIM: To investigate relevant factors of stem cell transplantation for treating diabetic foot. METHODS: Disposal, outcome, adjuvant method and safety during stem cell transplantation for treatment of diabetic foot were analyzed. RESULTS: ①After autologous stem cells were depurated at a low temperature for 24-48 hours, number of malignant stem cells decreased. Compared to simple stem cell transplantation, tissue regeneration and neovascularization increased after adding fibrin base during transplantation. ②Ankle-brachial index and transcutaneous oxygen pressure were obviously elevated, rest pain and intermittent lameness were improved, new collateral circulation appeared, and arterial blood flow increased in patients undergoing bone marrow stem cell transplantation in the treatment of ischemic disease of lower extremity. ③Chinese medicine for supplement- ing qi and activating blood circulation for stem cell transplantation fully played regulatory effects of biological responses. Adjuvant methods such as ultrasound ablation in combination of stem cell transplantation could significantly increase lower collateral circula- tion of broken popliteal artery. ④No significant adverse reaction or severe outcome was detected in autologous stem cell transplan- tation in a short term. CONCLUSION: ①Autologous stem cells after purified by low temperature can effectively purify malignant stem cells in bone marrow stem cell transplantation. Transplanted outcome can be elevated by adding fibrin. ②Adjuvant methods can enhance outcome of stem cell transplantation. ③Stem cell transplantation for treating diabetic foot has obtained satisfactory outcomes, but some problems still exist.
7.A study on donor remnant liver regeneration after right lobe adult living donor liver transplantation
Qian JI ; Zhiqiang CHU ; Wen SHEN ; Hong ZHENG ; Ji QI
Chinese Journal of General Surgery 2014;29(6):444-447
Objective To evaluate donor remnant liver regeneration and influencing factors at different stages after right lobe adult living donor liver transplantation (LDLT) using multi-slice spiral computed tomography (MSCT).Methods 68 living donors were included in this study,We did CT volumetric measurement of the liver by using IQQA-Liver workstation.Liver regenerative ratio (LRR) at different stages of donors after LDLT were calculated and compared,correlation coefficient and stepwise regression analysis were calculated.Results The difference between LRRs at different stages after LDLT were significant (F =3.323,P =0.009),there were significant difference between LRR of 7-day and 1-month,3-month (respectively t =-2.065,-2.214,all P < 0.05).The inclusion of middle hepatic vein and donor gender had no influence on LRR (respectively t =0.600,-0.622,1.464,0.926,-1.228,0.624,-0.688,0.131,all P > 0.05).There were negative correlation between the remnant liver volume and LRRs (P < 0.05).Conclusions MSCT is a valid modality to evaluate remnant liver regeneration after LDLT.Most evident remnant liver regeneration occurs in early stage after adult LDLT.
8.Plasma BNP levels and serum albumin, serum total bilirubin and prothrombin time in patients with cirrhosis correlation
Qunhong SHEN ; Jinghui CHU ; Mengli LUO ; Jianbo ZHOU
Chinese Journal of Biochemical Pharmaceutics 2017;37(2):288-290
Objective To investigate the correlation of plasma brain natriuretic peptide (BNP) level with serum albumin, serum total bilirubin and thrombin time in patients with liver cirrhosis.Methods RandomLy selected from January 2014 to June 2016 to our hospital diagnosis and hospitalization of 200 cases of cirrhosis patients, according to the standard of Child-Pugh classification provided by Chinese Medical Hepatology Division in 2006, 48 cases were Child A group, 96 cases were Child B group and 56 cases were Child C group.The plasma BNP, serum albumin, serum total bilirubin, prothrombin time and QTc interval of electrocardiogram were analyzed in the clinical data of each group of patients and the correlation between plasma BNP and their correlation.Results The levels of plasma BNP in Child A, B and C groups were higher than those in B group and B group.The correlation between plasma BNP and Child's grade showed a positive correlation, and the results of each group were statistically different (P<0.05).The plasma BNP level was negatively correlated with ALB ( P<0.05 ) .The level of plasma BNP was positively correlated with ALB ( P <0.05 ) .The correlation between plasma BNP and PTIL was correlated with TBIL.The correlation between plasma BNP and TBIL was significantly correlated with TBIL ( P <0.05), The higher the plasma BNP, the regression analysis showed that plasma BNP and TBIL were positively correlated, the difference was statistically significant (P<0.05).The correlation between plasma BNP level and QTc was analyzed.The QTc interval of plasma BNP level was higher than that of the control group ( P<0.01 ) , and the difference was statistically significant ( P <0.01 ) .Conclusion The plasma BNP level in patients with liver function is closely related to ALB, TBIL, PT, QTc interval, and has the value of evaluating and predicting liver function.
9.NUTRITIONAL STUDY ON CHINESE RICE
Chihping SHEN ; Ludjen KU ; Hsuching WANG ; Liendjen CHU
Acta Nutrimenta Sinica 1956;0(02):-
Husked and milled rice samples were prepared with laboratory rice mill from 23 representative varieties of paddy collected from the main rice production areas of China. All the samples were analyzed for the contents of protein, fat, crude fiber, ash, calcium, phosphorous, thiamine, riboflavin and niacin. The nutrient content of husked rice varies with variety and locality of growth. The range of protein content of the husked rice samples ranged from 6.7% to 9.6%.Rice samples had been analyzed at successive stages of milling for studying the effect on the nutrient content of milled rice. Results of this investigation showed that nutrient content declines progressively during the process of milling. While the protein content decreased insignificantly, the other nutrients, especially thiamine, ash, phosphorous, crude fiber and fat, were lost to a greater extent. In order to keep the thiamine content of polished rice not less than 0.15 mg %, the authors advocated that the overall weight removed during milling should not exceed 9-10% of the weight of husked rice.
10.Progress in Research on Neuroprotective Effects of Statins
Jun LI ; Jiami WU ; Zhaohu CHU ; Hengsheng SHEN
International Journal of Cerebrovascular Diseases 2006;0(09):-
Statins can substantially lower the incidence of cerebral ischemia and attenuate cerebral ischemic injury. Statins may exert their protective effects via different mechanisms, including stabilizing atherosclerotic plaques, improving endothelial function, reducing inflammatory reaction and reperfusion injury. Moreover, they may also reduce the occurrence of dementia by preventing ?-amyloid from formation and reducing secretion of apolipoprotein E.