Ovarian cancer has the highest mortality rate among gynecologic malignancies in developed countries. Most women present with advanced disease and require a combination of surgery and chemotherapy. One patient presented with recurrent ovarian cancer was initially treated with taxol and platinum-based compounds. Although response to these agents occurred, tumor progression was evident by elevated CA 125 levels and CT findings after a period of 4 months. This patient was then treated with topotecan and exhibited a response and stopped therapy. Topotecan exhibited activity in this patient with ovarian cancer resistent to both platinum and paclitaxel. We report a case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.
Developed Countries ; Drug Therapy ; Female ; Humans ; Mortality ; Ovarian Neoplasms* ; Paclitaxel ; Platinum ; Topotecan*

No abstract available.
Nasal Bone*

No abstract available.
Head* ; Magnetic Resonance Imaging* ; Necrosis*

Various measurements of cerebral ventricles in 50 normal newborn infants were performed, using ultrasonography. In transverse scan using linear array real-time scanner with 3 MHz transducer, the ratio of the distance between the falx and lateral wall of lateral ventricle to the hemispheric width was measured, In coronal scan through the anterior fontanelle using gray scale B-mode scanner with 5 MHz trand ucer, the ratios of the bifrontal diameter of the lateral ventricles to externally measured biparietal diameter and to head circumference were measured. Width of frontal horn at 5mm distance from the lateral end of frontal horn was also measured. In addition, the presence of cavum septi pellucidi was investigated in coronal scan. The result are as follows; 1. The lateral ventricle/hemispheric width ratio in transverse scan was 0.31±0.03. 2. Bifrontal diameter of lateralventricle/biparietal diameter ratio was 0.20±0.02 and bifrontal diameter of lateral ventricle/head circumference ration was 0.054±0.006. 3. Width of frontal horn was about 1mm and maximum width was 2 mm. 4. There was no significant difference in ventricular size between male and female, and among different gestation ages. 5. Cavumsepti pellucidi was found in 44 neonates (88%) among 50 normal neonates in coronal scan.
Animals ; Cerebral Ventricles ; Cranial Fontanelles ; Female ; Head ; Horns ; Humans ; Infant, Newborn ; Lateral Ventricles ; Male ; Pregnancy ; Transducers ; Ultrasonography

No abstract available.
Antibodies* ; Chungcheongnam-do* ; Diagnosis* ; Immunoglobulin G* ; Immunoglobulin M* ; Orientia tsutsugamushi* ; Rickettsia* ; Scrub Typhus*

No abstract available.
Antibodies* ; Chungcheongnam-do* ; Diagnosis* ; Immunoglobulin G* ; Immunoglobulin M* ; Orientia tsutsugamushi* ; Rickettsia* ; Scrub Typhus*

PURPOSE: This study compared the performance between the fully-automated external defibrillator (F-AED) and the semi-automated external defibrillator (S-AED) when used by laypersons. METHODS: Thirty-three laypersons participated in a mannequin simulation study as part of Cardio-Pulmonary Resuscitation (CPR) training courses. After 30 minutes of didactic education for the Automated External Defibrillator (AED), they watched a video on how to use the fully-automated external defibrillator (F-AED) and a semi-automated external defibrillator (S-AED) instead of a hands-on education. Laypersons performed the S-AED first, then the F-AED. Performances and shock delivery time intervals were recorded and evaluated. RESULTS: The performances in shock delivery were better with the F-AED, although the overall performance was statistically insignificant. In terms of shock delivery interval, the F-AED was shorter than the S-AED (54.48+/-2.84 sec vs. 64.76+/-3.57 sec, respectively, p<0.01). In the post survey, F-AED had a higher preference (F-AED vs. S-AED 23(70%) vs. 5(15%), respectively, p<0.001). CONCLUSION: The F-AED had a better performance and shorter shock delivery time interval than the S-AED. The F-AED should thus be considered for use, outside of the hospital, on cardiac arrest patients for early defibrillation.
Cardiopulmonary Resuscitation ; Defibrillators ; Heart Arrest ; Humans ; Manikins ; Shock

Bromidrosis is a disorder characterized by rancid body odor which influences a patient's social life and mental health. The therapeutic modalities and the mechanism of bromidrosis have been carefully studied, however, there have been few reports about the genetic inheritance of bromidrosis. We investigated the family history of 42 patients who were operated on for bromidrosis and followed up to the third generation in 10 cases. The results were as follows: Results of investigation which were followed up the second generation. The fathers of five patients and the mothers of 11 patients had bromidrosis in 18 male patients. The fathers of six patients and the mothers of 12 patients had bromidrosis in 24 female patients. Thirty-four patient (81.0%) among a total of 42 have a single parent with bromidrosis. Result of investigation which were followed up to the third generation Bromidrosis was occurred in 17 of 42 patients (40.5%) in the second generation, and 18 of 27 patients (66.7%) in the third generation. In one case, a father transmitted bromidrosis to his three sons, and as a result, X-linked inheritance could be ruled out Bromidrosis was not skipped in every generation of all families. We on conclude that bromidrosis is an autosomal dominant inherited disorder.
Fathers ; Female ; Genes, X-Linked ; Humans ; Male ; Mental Health ; Mothers ; Odors ; Single Parent ; Wills*

No abstract available.
Placenta* ; Trophoblasts*

Objective: The aim of this study was to investigate the epidemiological characteristics of disasters to analyze typical disasters in Korea based on the concept of mass casualty incidents (MCIs). Methods: We reviewed literature from data sources including the National Emergency Management Agency, the National Police Agency, and other agencies. We analyzed cases of MCIs to investigate their epidemiological characteristics such as natural disasters, types of man-made disasters, incidence, casualties, and mortalities by descriptive methods. Results: From 1985 to 2012, the incidence of man-made MCIs (4,827,893 cases) with the number of the deceased at 160,908 was higher than that of natural disasters (532 cases) with the number of deceased at 4,129. These included 219 cases (41.0%) of heavy rains with the number of deceased at 2,067 (50.1%), 161 cases (30.1%) of gales with the deceased numbering 64 (1.6%), 58 cases (10.9%) of heavy snowfall with the number of deceased at 673 people (16.3%), 51 cases (9.6%) of typhoon with 1,290 people deceased (31.2%), and 43 other cases (8.1%). Man-made disasters from 1999 to 2011 included 3,055,487 cases (85.7%) of traffic accidents with 89,967 (92.5%) deceased, 496,631 cases (13.9%) of fire with the deceased victims numbering 6,130 (6.3%), and 12,924 cases (0.4%) of maritime disasters with the deceased at 1,150 people (1.2%). Conclusion The concept of disasters has to be changed to reflect the contemporary situation in Korea. The epidemiological characteristics of MCIs as conventional disasters revealed that man-made disasters such as traffic accidents, fires, and natural disasters such as heavy rain, snowfall, and gales occur most frequently and result in the most casualties.