1.Chronobiology in rehabilitation for hemiplegia due to cerebrovascular accident
Journal of Medical and Pharmaceutical Information 2004;0(8):33-36
This study was carried out on 44 patients with celebrovascular accident (CVA) at Huu Nghi Hospital. Results showed that CVA infarctus particularly happens in the rest time much more than in working time (66.0%). 86.6% of the patients had been started to rehabilitation is less than 10 days after CVA. Average distance of the time from CVA to: help to sit up: 4.59 days, one's self sit up: 8.29 days, help to stand up: 9.55 days, one's self stand up: 10.5 days, help to walk: 10.87 days, one's self walk: 13.26 days
Chronobiology
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Cerebrovascular Accident
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Rehabilitation
3.The Relationship between Shift Work and Work-related Injuries among Korean Workers.
Tae Jun PARK ; Do Myung PAEK ; Kee Ock JOH ; Jung Sun PARK ; Sung il CHO
Korean Journal of Occupational and Environmental Medicine 2012;24(1):52-60
OBJECTIVES: The aim of this study was to evaluate the relationship between shift work and work-related injuries in a representative sample of Korean workers. METHODS: We used data from the Korean Working Condition Survey of 2006. The participants were 7,075 Korean workers 15 to 64 years of age. Logistic regression was employed to estimate the relationship between shift work and work-related injury using the SAS version 9.2 program. RESULTS: Shift work was significantly related to work-related injuries compared to non-shift workers(OR 2.40, 95% CI=1.65~3.48). When personal and occupational risk factors were accounted for, shift work had a statistically meaningful relationship with work-related injuries compared to non-shift work(OR 1.79, 95% CI=1.20~2.66). CONCLUSIONS: In this study, shift workers appear to have a higher risk of work-related injuries compared to non-shift workers. Work-related injuries in shift workers could be attributed to circadian rhythm disorder and sleep problems. Suitable arrangements that ensure flexible working times are needed for shift workers. Further study will be needed to identify and mitigate work-related injuries among shift workers.
Chronobiology Disorders
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Dietary Sucrose
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Humans
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Logistic Models
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Phenothiazines
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Risk Factors
4.Is the Circadian Rhythm Dysregulation a Core Pathogenetic Mechanism of Bipolar Disorder?.
Journal of Korean Neuropsychiatric Association 2018;57(4):276-286
Circadian rhythm is a periodic and continuous change in physiological, behavioral, and mental characteristics that occurs in most organisms on the Earth, because the Earth rotates in a 24-hour cycle. The circadian system regulates daily rhythms of physiology and behavior, such as the sleep/wake cycle, body temperature, hormonal secretion, and mood. The influence of circadian rhythm is very powerful, but limited research has addressed its effects. However, many recent studies have shown that circadian dysregulation may play an important role in the pathogenesis of bipolar disorder. This review study examined current and noteworthy studies, including the authors' own works, and proposes a possible clinical application of bipolar disorder based on evidence that circadian rhythm dysregulation in bipolar disorder may be a key pathogenetic mechanism.
Bipolar Disorder*
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Body Temperature
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Chronobiology Disorders
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Circadian Rhythm*
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Physiology
5.Research progress in circadian rhythms in the application of psychological rehabilitation of cancer patients.
Xiaofei LUO ; Panpan XIAO ; Lijun LI ; Yinglong DUAN ; Cheng Andy SK ; Jianfei XIE
Journal of Central South University(Medical Sciences) 2022;47(12):1740-1747
The psychological distress of cancer patients seriously affects their therapeutic effects. Effective psychological rehabilitation of cancer patients significantly improves their survival chance and quality of life. Circadian rhythm results from adaptation to the environment during the organism's evolution. When the endogenous clock system is disrupted or the external environment is changed, the body and the environment are out of synchronization, and the circadian rhythm will be disrupted. Circadian rhythm disorder is a common phenomenon in cancer patients, and the changes of circadian rhythm are closely related to their psychological distress. Many studies believe that the circadian rhythm disorder of cancer patients may directly or indirectly affect their psychology through various mechanisms, and targeted intervention by regulating the circadian rhythm of patients may be an essential means to promote the psychological rehabilitation.
Humans
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Quality of Life
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Circadian Rhythm/physiology*
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Chronobiology Disorders
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Neoplasms
6.Circadian Rhythm Hypotheses of Mixed Features, Antidepressant Treatment Resistance, and Manic Switching in Bipolar Disorder.
Heon Jeong LEE ; Gi Hoon SON ; Dongho GEUM
Psychiatry Investigation 2013;10(3):225-232
Numerous hypotheses have been put forth over the years to explain the development of bipolar disorder. Of these, circadian rhythm hypotheses have gained much importance of late. While the hypothalamus-pituitary-adrenal (HPA) axis hyperactivation hypothesis and the monoamine hypothesis somewhat explain the pathogenic mechanism of depression, they do not provide an explanation for the development of mania/hypomania. Interestingly, all patients with bipolar disorder display significant disruption of circadian rhythms and sleep/wake cycles throughout their mood cycles. Indeed, mice carrying the Clock gene mutation exhibit an overall behavioral profile that is similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, and lower anxiety. It was recently reported that monoamine signaling is in fact regulated by the circadian system. Thus, circadian rhythm instability, imposed on the dysregulation of HPA axis and monoamine system, may in turn increase individual susceptibility for switching from depression to mania/hypomania. In addition to addressing the pathophysiologic mechanism underlying the manic switch, circadian rhythm hypotheses can explain other bipolar disorder-related phenomena such as treatment resistant depression and mixed features.
Animals
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Bipolar Disorder*
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Chronobiology Disorders
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Circadian Rhythm*
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Depression
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Depressive Disorder, Treatment-Resistant
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Humans
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Mice
7.Developments of chronobiology abroad.
Journal of Biomedical Engineering 2005;22(1):185-188
Developments of chronobiology abroad are forging ahead in elucidating the cellular and molecular basis and the influential factors of circadian clock such as light, jet lag, pharmaceutical. This article also reviews the influence of circadian system on human physiology and disease occurrence. The circadian-based therapy holds promising future and the research emphasis is on prognosis and prevention.
Biological Clocks
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Chronobiology Phenomena
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Circadian Rhythm
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physiology
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Drug Chronotherapy
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Jet Lag Syndrome
8.The progress of studies on the relation between circadian rhythm disruption and cancer.
Shengwu LI ; Jia WU ; Xiaofeng HU ; Hong XUE
Journal of Biomedical Engineering 2012;29(5):991-994
Like functions of other organisms, most of the physiological and behavioral functions of human are characterized by day-night rhythms. The rhythms which exhibit approximately 24-hour periodicity are called as circadian rhythms. This review is to summarize the progress of studies on relation of circadian rhythum disruption and cancer. The research results from animal experiments and population-based epidemiological studies have showed that cancer is closly related to circadian rhythm. Although numrous studies have demonstrated the close relation between circadian rhythm disruption and cancer, the mechanism is not yet clear. The current studies attributed decreased level of melatonin secretion and disruption of clock genes expression to the mechanism of carcinogenesis of circadian rhythm disruption.
Animals
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Chronobiology Disorders
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physiopathology
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Humans
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Neoplasms
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epidemiology
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physiopathology
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Risk Factors
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United States
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epidemiology
9.Relationship between Circadian Rhythm Disorder of Blood Pressure and Ischemic Stroke.
Jian GE ; Ming Li HE ; Yi TANG ; Yu Meng LIU ; Jing JIN ; Dong ZHANG
Acta Academiae Medicinae Sinicae 2020;42(6):831-835
Hypertension plays an important role in the pathogenesis of stroke,which,however,is only known at the blood pressure level.The relationship between circadian rhythm of blood pressure(especially the circadian rhythm disorder of blood pressure)and stroke has been a hot research topic.This article reviews the concept of circadian rhythm of blood pressure,classification of circadian rhythm disorder of blood pressure,and the relationship of circadian rhythm disorder of blood pressure with ischemic stroke.
Blood Pressure
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Brain Ischemia/complications*
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Chronobiology Disorders/complications*
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Circadian Rhythm
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Humans
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Hypertension/complications*
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Ischemic Stroke/complications*
10.Association between circadian rhythm disorder and comorbidity of anxiety and depression in adolescents.
Wan Yu CHE ; Fang Biao TAO ; Xiao Yan WU
Chinese Journal of Preventive Medicine 2023;57(9):1469-1474
Adolescents are in a transition period from children to adults, during which they are prone to a variety of emotional disorders, with anxiety and depression being the most common disorders. Anxiety and depressive symptoms are highly correlated and the comorbidity of anxiety and depression is common. At the same time, the most prominent behavioral changes in adolescence are the emergence of getting up late and sleeping late, and the circadian rhythm begins to delay. Previous studies have shown that circadian rhythm is closely related to anxiety and depression, but the association between circadian rhythm disorder and comorbidity of anxiety and depression remains unclear. This article reviews the prevalence, association and potential biological mechanism of circadian rhythm disorder and comorbidity of anxiety and depression in adolescents, so as to provide a possible reference for the prevention and control of comorbidity of anxiety and depression in adolescents.
Adult
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Child
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Adolescent
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Humans
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Depression/epidemiology*
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Anxiety/epidemiology*
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Comorbidity
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Chronobiology Disorders
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Sleep