This paper examined epistemological directions of studies related to attitudes toward persons with disabilities and reviewed definitions and accruement of knowledge in this body of literature. Historical perspectives concerning attitudes toward persons with disabilities were linked to socio-political issues, civil rights movements, models of disability, and differing values in society. Philosophical input of recent studies were examined and centered on unique directions in the research literature concerning attitudes toward persons with disabilities. Implications that argue for continued research in attitudes toward persons with disabilities were discussed.