Primary ovarian choriocarcinoma is an extremely rare germ cell neoplasm, and the prognosis is poor. Especially, the diagnosis of primary ovarian nongestational chori-ocarcinoma can be reliably established in a girl or innocent virgin. We report a case of primary ovarian, nongestational, pure choriocarcinoma in a 16-year-old woman. She died within 1 year after diagnosis in spite of the treatment with surgery and combin-ation chemotherapy.
Adolescent ; Choriocarcinoma ; Choriocarcinoma, Non-gestational* ; Diagnosis ; Drug Therapy ; Female ; Germ Cells ; Humans ; Pregnancy ; Prognosis

Primay ovarian choriocarcinoma is very rare disease. Especially, non-gestational choriocarcinoma of ovary has worse prognosis than gestational tumor. Here, we report a non-gestational pure ovarian choriocarcinoma in 11 years old woman with the review of literature.
Child ; Choriocarcinoma ; Choriocarcinoma, Non-gestational* ; Female ; Humans ; Ovary ; Pregnancy ; Prognosis ; Rare Diseases

Primary ovarian choriocarcinoma arising from a germ cell is an extremely rare occurrence, especially in postmenopausal women, and the prognosis is poor. Non-gestational choriocarcinoma of the ovary (NGCO) accounts for 0.6% or less of all ovarian neoplasms. It is important to distinguish gestational choriocarcinomas of the ovary (GCO) from other carcinomas because of the poor prognosis of NGCO. We describe a case of NGCO with lung metastasis in a 55 year old woman, which we present together with a brief review of the literature.
Choriocarcinoma ; Choriocarcinoma, Non-gestational ; Female ; Germ Cells ; Humans ; Lung ; Neoplasm Metastasis ; Ovarian Neoplasms ; Ovary ; Postmenopause ; Pregnancy ; Prognosis

The authors report a xase of primary non-gestational choriocarcinoma(PNGCO) of the ovary in a prepubertal female patient and reviewed. It is an extremely rere disease of which incidence is one in 369 million. Major clinical symptom is abdominal pain, precociois puberty and it can be misdiagneosed as ectopic pergnancy. Distinction from gestational choriocarcinoma(GCO) of the ovary is important because of the worse prognosis of PNGCO. But no distinctive ultrastructural or immunohistochemical differences are found between PNGCO and GCO. Most acceptable treatment modality is an aggressive surgical therapy and systemic chemotherapy, but its progrosis is poor.
Abdominal Pain ; Adolescent ; Choriocarcinoma, Non-gestational* ; Drug Therapy ; Female ; Humans ; Incidence ; Ovary* ; Prognosis ; Puberty

Primary mediastinal choriocarcinoma is a very rare malignant tumor unrelated to pregnancy. Here a case of primary mediastinal choriocarcinoma was reported. The patient was a 13-year-old boy. He presented with shortness of breath, chest pain, fever, irritable cough and weight loss. The imaging examination showed a huge space-occupying lesion at the right edge of mediastinum. The autopsy results showed right lung and mediastinal choriocarcinoma cell carcinoma. After the introduction of the case, this paper reviewed the clinical characteristics, diagnosis and treatment of primary mediastinal choriocarcinoma.
Adolescent ; Choriocarcinoma, Non-gestational ; diagnosis ; pathology ; therapy ; Diagnosis, Differential ; Humans ; Male ; Mediastinal Neoplasms ; diagnosis ; pathology ; therapy

Adenocarcinoma ; pathology ; therapy ; Choriocarcinoma, Non-gestational ; pathology ; therapy ; Combined Modality Therapy ; Female ; Humans ; Lung Neoplasms ; secondary ; Middle Aged ; Neoplasms, Germ Cell and Embryonal ; pathology ; therapy ; Urinary Bladder Neoplasms ; pathology ; therapy ; Uterine Neoplasms ; pathology ; therapy

Choriocarcinoma is a HCG-producing epithelial neoplasm derived from either trophoblastic or totipotential germ cells. It is a highly malignant tumor, which is rapidly invasive and widely metastatic, and in most cases develops within the uterus after a normal or abnormal gestation, including ectopic pregnancy. Non-gestational choriocarcinoma rarely occur as a primary neoplasm in the gonads or in the extragonadal midline locations such as mediastinum, retroperitoneum, and pineal gland. It also has been reported very rarely to arise in parenchymal organs such as the prostate, lung, breast, brain, liver, kidney, bladder, vagina, and gastrointestinal tract. A 58-year old man was admitted to our hospital with symptoms of tarry stool and epigastric discomfort. The endoscopic biopsy specimen initially revealed pooly differentiated carcinoma of stomach with regional lymph node metastasis. Patient underwent distal gastrectomy with Billroth II anastomosis. Choriocarcinoma of stomach with well differentiated tubular adenocarcinoma was diagnosed by the surgical biopsy specimen, and the serum level of beta-HCG was 2,775 mIU/mL.In three months after operation, the patient presented with pain on right upper quadrant abdomen, and the CT scan revealed multiple liver metastasis. Bleomycin, etoposide, and cisplatin (BEP) combination chemotherapy were administered, but he died three months after the initial diagnosis.
Abdomen ; Adenocarcinoma* ; Biopsy ; Bleomycin ; Brain ; Breast ; Choriocarcinoma* ; Choriocarcinoma, Non-gestational ; Cisplatin ; Diagnosis ; Drug Therapy, Combination ; Etoposide ; Female ; Gastrectomy ; Gastroenterostomy ; Gastrointestinal Tract ; Germ Cells ; Gonads ; Humans ; Kidney ; Liver ; Lung ; Lymph Nodes ; Mediastinum ; Middle Aged ; Neoplasm Metastasis ; Neoplasms, Glandular and Epithelial ; Pineal Gland ; Pregnancy ; Pregnancy, Ectopic ; Prostate ; Stomach ; Tomography, X-Ray Computed ; Trophoblasts ; Urinary Bladder ; Uterus ; Vagina