1.Stent-Graft Repair of Common Carotid Pseudoaneurysms in Behcet's Syndrome.
Boyoung CHUNG ; Donghoon CHOI ; Choongwon GOH ; Doyoun LEE ; Won Heum SHIM
Korean Circulation Journal 1998;28(8):1404-1408
We report on a patient with Behcet's syndrome who had two pseudoaneurysms at the junction of a saphenous vein graft and the native common carotid artery. He had experienced graft interposition due to the aneurysm rupture, but the saphenous vein was interpositioned due to the graft reobstruction. We successfully repaired the pseudoaneurysms with stent-graft.
Aneurysm
;
Aneurysm, False
;
Behcet Syndrome*
;
Carotid Artery Injuries*
;
Carotid Artery, Common
;
Humans
;
Rupture
;
Saphenous Vein
;
Transplants
2.Insulin Resistance as an Associated Factor of Essential Hypertension in Korean.
Hongkeun CHO ; Choongwon GOH ; Sung Soon KIM ; Hyun Chul LEE ; Kap Bum HUH ; Hae Kyung CHUNG ; Heesun KIM ; Jongho LEE
Korean Circulation Journal 1996;26(5):1020-1029
BACKGROUND: The insulin resistance is reported as the independent risk factor of the DM and the ischemic heart disease. The association between the insulin resistance and the essential hypertension was reported at the various countries and races. We performed this study to know if the hypertensive patients show the increased insulin resistance than that of the normotensive persons and factors that influence the insulin resistance and the blood pressure. METHODS: The serum lipid profiles, OGTT, body habitus measurement and abdominal CT at umbilical level were performed in 24 hypertensive patients(male : 10, female : 14) and 45 normotensive persons(male : 19, female : 26) who showed the same distributions of age, sex, weight and body mass index(BMI). RESULTS: The average age of the hypertensive group was 49.1+/-7.9 years, and that of the normotensive group was 46.1+/-7.6 years(p>0.05). The average blood pressure of the hypertensive group was 152.2+/-14.2/98.4+/-6.4mmHg and that of the normotensive group was 116.8+/-9.4/78.2+/-49.mmHg(p<0.001). The hypertensive group had significantly higher area under curve(AUC) of glucose(246.8+/-30.4 Vs 219.2+/-32.2mg/dL.hr) and AUC of insulin(88.9+/-38.2 Vs 69.6+/-34.2microU/mL.hr) than the normotensive group(p<0.05), while there were no differences in the age, sex, weight, body mass index(BMI) and waist to hip ratio(WHR) between two groups. They had nodifferences in lipid profile and plasma renin activity. In CT assessment, the hypertensive group had significantly higher visceral fat to thigh muscle area ratio(VSFTM ratio)(0.61+/-0.29 Vs 0.47+/-0.20) and visceral fat to thigh muscle and fat area ratio(VSFTMF ratio)(0.27+/-0.10 Vs 0.22+/-0.13)(p<0.05), while they had same degree of visceral fat to subcutaneous fat area(VS) ratio and visceral fat area. The visceral fat area, VSFTM ratio, VS ratio, visceral fat area to thigh fat area ratio(VSFTF ratio) were positively correlated with AUC of insulin and AUC of glucose ordinary(p<0.05). After adjustment for plasma insulin, AUC of insulin, VS ratio, VSFTM ratio, age and BMI, the AUC of glucose was positively correlated with the diastolic blood pressure(R square=0.19, p <0.05) and the AUC of glucose and WTR were positively correlated with the systolic blood pressure(R square=0.26, p<0.05). THe subgroup over the 75 percentile of AUC of glucose, AUC of insulin and VSFTM ratio in study population had significantly higher odds ratio of the hypertension(OR of AUC of glusose : 5.8, OR of AUC of insulin : 3.2, OR of VSFTM ratio : 4.5, p<0.05). CONCLUSION: These results suggest that the insulin resistance is more prevalent in the hypertensive patients and associated with the hypertension.
Area Under Curve
;
Blood Pressure
;
Body Weight
;
Continental Population Groups
;
Female
;
Glucose
;
Glucose Tolerance Test
;
Hip
;
Humans
;
Hypertension*
;
Insulin Resistance*
;
Insulin*
;
Intra-Abdominal Fat
;
Myocardial Ischemia
;
Odds Ratio
;
Plasma
;
Renin
;
Risk Factors
;
Subcutaneous Fat
;
Thigh
;
Tomography, X-Ray Computed
3.Systemic Lupus Erythematosus Presented with Streptococcal Myositis: A Case Report.
Donggil HAHM ; Moonsup LIM ; Sin Kwon CHOI ; Choongwon LEE ; Younsoo HWANG
The Journal of the Korean Orthopaedic Association 2005;40(3):361-364
Streptococcal myositis is an extremely uncommon infectious disease that is caused by Group A Streptococcus (GAS). A GAS infection spreads rapidly and diffusely through the muscle, resulting in edema and necrosis. This can lead to streptococcal toxic shock syndrome with an extremely hig mortality. We report a 42 year-old female patient with Streptococcal myositis accompanying with systemic lupus erythematosus who initially presented with fever, severe pain, and tenderness on the calf without any prodromal symptom of myositis. Despite the aggressive management, her general symptoms were aggravated and she died 7 days later as result of the toxic shock syndrome.
Adult
;
Communicable Diseases
;
Edema
;
Female
;
Fever
;
Humans
;
Lupus Erythematosus, Systemic*
;
Mortality
;
Myositis*
;
Necrosis
;
Prodromal Symptoms
;
Shock, Septic
;
Streptococcus
4.Body Weight and Bone Density Changes in Patients with Ankylosing Spondylitis Receiving Anti-Tumor Necrosis Factor-alpha Treatment.
Jangwon LEE ; Minsuk JUNG ; Donghyun KIM ; Seunghyun LEE ; Sook Kyung OH ; Youngsun JO ; Sanghwan BYUN ; Kyoungmin NAM ; Choongwon LEE
Korean Journal of Medicine 2013;85(5):489-494
BACKGROUND/AIMS: To determine the changes in body weight and bone mineral density in patients with ankylosing spondylitis (AS) receiving anti-tumor necrosis factor-alpha (TNF-alpha) treatment. METHODS: Thirty-one patients with AS (25 males and 6 females) who fulfilled the Modified New York Criteria for AS were included in this retrospective study. All patients had active disease that eventually required anti-TNF-alpha treatment. Each patient received anti-TNF-alpha treatment (etanercept 25 mg twice weekly or adalimumab 40 mg twice monthly) for more than 2 years. Body weight, disease activity as Bath ankylosing spondylitis disease activity index (BASDAI), C-reactive protein, erythrocyte sedimentation rate (ESR), lumbar bone mineral density (LBMD), and femoral bone mineral density (FBMD) were measured at baseline and at 1 and 2 years after initiating anti-TNF-alpha treatment. RESULTS: There was a significant increase in mean body weight at 1 year (1.1 +/- 3.8 kg) and at 2 years (1.7 +/- 4.8 kg) compared with baseline. The gains in mean BMD of the lumbar spine were significant at 1 year (0.4 +/- 0.4) and 2 years (0.5 +/- 0.7) compared with baseline. Mean BMD of the femur was also increased at 1 year (0.08 +/- 0.7) and 2 years (0.1 +/- 0.8) compared with baseline, but these differences were not statistically significant. There were significant decreases in BASDAI at 1 year (-3.3 +/- 2.8) and at 2 years (-3.6 +/- 2.8) compared with baseline. CONCLUSIONS: This study showed significant increases in body weight, lumbar BMD, and BASDAI at 1 year and 2 years in patients with ankylosing spondylitis after receiving anti-TNF-alpha treatment.
Antibodies, Monoclonal, Humanized
;
Baths
;
Blood Sedimentation
;
Body Weight*
;
Bone Density*
;
C-Reactive Protein
;
Cachexia
;
Femur
;
Humans
;
Male
;
Necrosis*
;
Retrospective Studies
;
Spine
;
Spondylitis
;
Spondylitis, Ankylosing*
;
Adalimumab
5.Body Weight and Bone Density Changes in Patients with Ankylosing Spondylitis Receiving Anti-Tumor Necrosis Factor-alpha Treatment.
Jangwon LEE ; Minsuk JUNG ; Donghyun KIM ; Seunghyun LEE ; Sook Kyung OH ; Youngsun JO ; Sanghwan BYUN ; Kyoungmin NAM ; Choongwon LEE
Korean Journal of Medicine 2013;85(5):489-494
BACKGROUND/AIMS: To determine the changes in body weight and bone mineral density in patients with ankylosing spondylitis (AS) receiving anti-tumor necrosis factor-alpha (TNF-alpha) treatment. METHODS: Thirty-one patients with AS (25 males and 6 females) who fulfilled the Modified New York Criteria for AS were included in this retrospective study. All patients had active disease that eventually required anti-TNF-alpha treatment. Each patient received anti-TNF-alpha treatment (etanercept 25 mg twice weekly or adalimumab 40 mg twice monthly) for more than 2 years. Body weight, disease activity as Bath ankylosing spondylitis disease activity index (BASDAI), C-reactive protein, erythrocyte sedimentation rate (ESR), lumbar bone mineral density (LBMD), and femoral bone mineral density (FBMD) were measured at baseline and at 1 and 2 years after initiating anti-TNF-alpha treatment. RESULTS: There was a significant increase in mean body weight at 1 year (1.1 +/- 3.8 kg) and at 2 years (1.7 +/- 4.8 kg) compared with baseline. The gains in mean BMD of the lumbar spine were significant at 1 year (0.4 +/- 0.4) and 2 years (0.5 +/- 0.7) compared with baseline. Mean BMD of the femur was also increased at 1 year (0.08 +/- 0.7) and 2 years (0.1 +/- 0.8) compared with baseline, but these differences were not statistically significant. There were significant decreases in BASDAI at 1 year (-3.3 +/- 2.8) and at 2 years (-3.6 +/- 2.8) compared with baseline. CONCLUSIONS: This study showed significant increases in body weight, lumbar BMD, and BASDAI at 1 year and 2 years in patients with ankylosing spondylitis after receiving anti-TNF-alpha treatment.
Antibodies, Monoclonal, Humanized
;
Baths
;
Blood Sedimentation
;
Body Weight*
;
Bone Density*
;
C-Reactive Protein
;
Cachexia
;
Femur
;
Humans
;
Male
;
Necrosis*
;
Retrospective Studies
;
Spine
;
Spondylitis
;
Spondylitis, Ankylosing*
;
Adalimumab