A 41 year-old man had dark pigmented papules and plaques, 4 to 15 mm in size, on the proximal portion of the dorsum of the penile shaft and pubic area of 8 months duration. Over next several months, flesh colored, macerated papules, 2 to 4 mm in size, appeared on the left side of the scrotum Light microscopic examination from a pigmented lesion of the penile shaft showed typical findings of Bowen's disease. Ultrastructural findings included: widening of intercellular space, a decrease in the number of desmosomes with microvillous projections, aggregation of tonofilaments, an increase in the mitotic keratinocytes, an increase in the number of melanin granules, and disorganized bundles of tonofilaments surrounding chromosomes. Virus-like particles were not observed. Based on the ultrastructural findings and review of literatures, it seems to be probable that bowenoid papulosis is a clinical variant of Bowens disease.
Adult ; Bowen's Disease ; Desmosomes ; Extracellular Space ; Genitalia* ; Humans ; Intermediate Filaments ; Keratinocytes ; Melanins ; Scrotum

Antibiotic therapy for acne is now considered one of the most effective regimen. Thirty years ago, oral antibiotics were introduced for acne vulgaris and topical preparations have been available by prescription for more than 15 years. Recently, clindamycin, erythromycin and tetracycline were regarded as the most effective and widely used antibiotics. Many authors reported that clindamycin was a mast effective topical antibiotic for acne vulgaris but side effects, i.e., contact dermstitis or pseudomembranous colitis were reported. The author studied the clinical effectiveness and side effects of Fabrys salution, which has been used as an antiseptic and keratolytic agents, and Fabrys solution containing chloramphenicol or clindamycin. Fifty three patients who were followed for 6 weeks were studied. They were divided into three groups: group I was treated with Fabrys solution(F solution), group II was treated with Fabrys solution containing chloramphenicol(F-c solution) and group Ill was treated with Fabrys solution containing clindamycin(F-cd solution).
Acne Vulgaris* ; Anti-Bacterial Agents* ; Chloramphenicol ; Clindamycin ; Enterocolitis, Pseudomembranous ; Erythromycin ; Humans ; Keratolytic Agents ; Prescriptions ; Tetracycline

Speckled lentiginous nevus is a clinical variant of nevus-cell nevus first described by Stewart et al. in 1978. It is characterized by small, dark hyperpigmentated speckles superimposed on a tannish-brown background. The speckled areas show varying histologic patterns ranging from nevus incipiens to junctional or compound nevus. The back ground shows histologic features of Ientigo simplex. Recently, we observed clinical and histological features of 5 cases of speckled lentiginous nevi. The age of onset ranges from birth to infancy, The locations are face, thigh, back and scapula. One has zosteriform distribution in upper extrernity, chest and back. Histologic features of speckles are junctional or compound nevus. We suggest that the origin of dark speckles may be from the tannish-brown background, lentigo simplex.
Age of Onset ; Lentigo ; Nevus* ; Parturition ; Scapula ; Thigh ; Thorax

We reported a case of subcutaneous mass in a 22-year-old lady having unusual histopathologic findings mixed with both features of pilomatricoma and epidermal cyst and the meanings of these peculiar findings were discussed.
Epidermal Cyst* ; Humans ; Pilomatrixoma* ; Young Adult

No abstract available.
Hyperpigmentation*