Nevocellular nevi are benign tumors composed of nevus cells, which are peculiar to man and almost everyone has a few nevi somewhere on his body. The dermatologist has a unique opportunity to study the most common neoplaam of man, the nevocellular nevus, becasue of its ready accessibility to visual observation and its simplicity obtaining for microscopic specimen. Much has been leamed last two decades about the nature, origin, and development of the nevocellular nevus. However, most of the these knowledge obtained by investigation of Caucasians. The investigation of colored subjects are scarcely reported. This paper is an attempt to clarify 1) the clinical features of nevocellular nevi developed on Korean, colored race. 2) the incidence of pigmented nevi developed on normal individuals and vitiligo patients. During the last l0 month(1975. 3. - 1975. 12. ) 525 normal individuals and 67 vitiligo patients were randomly selected and were investigated about incidence and clinical morphology(according to Levers clinical classification) of pigmented nevi developed on different body areas. The results were summarized as follows. 1) There was average 20 nevocellular nevi in each Korean individuals. Average 23 nevi was found in male and 15 nevi in female. 2) The number of nevus and its morphology were closely related to the age of host and body areas. 3) The flat type nevi was the most common type nevi and face was the most common site among the body areas. 4) In comparison with Caucasian, it seemed no racial difference in clinical features of the pigmented nevus. 5) There was no difference between the incidence of nevocellular nevus developed on normal individual and that of vitiligo patient.
Continental Population Groups ; Female ; Humans ; Incidence ; Korea* ; Male ; Nevus* ; Nevus, Pigmented ; Vitiligo

Separation of Langerhans cells in epidermis of 16 healthy Korean individuals were performcd. Separation of Langerhans cells by density gradient centrifugation on a colloidal sillica(percoll) polyvinilpyrrolidone gradient. And autologous, allogeneic mixed skin cell leukocyte culture reaction was done with each fractionatcd cpidermal cell suspensions. Also lymphocytes, epidermal cells was cultured in media alone, respectively. The results was quantitated by the incorporation of H-thymidine by p-liquid scintillation counter. The densities of I angerhans cells within the epidermal cells, fraction-2 was most higher concentration (22.0+2.8%) and fraction-5 was most lower concentration (3.4+ l.9%). 2. In the comparison of the results of Langehans cells enriched and depleted population in autologous mixed skin cell leukocyte culture reaction, the former was higher than the latter on lymphocyte stimulatory capacity. There was significant differences(p<0.005) And also same as result in allogeneic mixed skin cell leukocyte culture reaction. 3. Langerhans cells enriched fraction in this study was more lymphocyte stimulatory capacity than depleted fraction in allogeneic mixed skin cell leukocyte culture(p<0.01~0.05). Ailogeneic mixed skin cell leukocyte culture reaction was more lymphocyte stimulatory capacity than the autologous(p<0.005~0.05).
Centrifugation, Density Gradient* ; Colloids* ; Epidermis ; Humans* ; Langerhans Cells* ; Leukocytes* ; Lymphocytes ; Scintillation Counting ; Silicon Dioxide* ; Skin* ; Suspensions

A 25-year-old man with familial benign chronic pemphigus presented with a one-year history of a localized pruritic recurrent eruption on his perianal area, Physical examination showed moist, macerated, fissured and scaly patches on erythematous base, A biopsy specimen showed extensive intraepidermal separation containing acantholytic cells. Electron microscopic observation showed widened intercellular space, detachment of the tonofilaments from the desmosomes, and subsequent concentration of the tono filaments around the nucleus. Microvilli were elorigated, thinned and branehed. 1)esmosomes were reduced in number. This case is unique in its clinical location, showing no family tendency.
Adult ; Biopsy ; Desmosomes ; Extracellular Space ; Humans ; Intermediate Filaments ; Microvilli ; Pemphigus, Benign Familial* ; Physical Examination

Metastatic cancers to the skin are rare and usually originate in the lung, breast, large intestine, or ovary. They commonly present with lesions in the area overlying the neoplasm, but the morphology, pattern and distribution may vary. Hepatoma metastasizes to the lungs, adrenal glands, regional lymph nodes, portal vein, gallbladder, pancreas, bone, hepatic vein, kidney, mediastinum, less commonly, the heart, peritoneum, diaphragm, and bone marrow. Cutaneous metastasis from hepatoma occurs very rarely and, if present, it usually presents as solitary or multiple nodules. We report two cases of cutaneous metastases from hepatoma.
Adrenal Glands ; Bone Marrow ; Breast ; Carcinoma, Hepatocellular* ; Diaphragm ; Female ; Gallbladder ; Granuloma, Pyogenic* ; Heart ; Hepatic Veins ; Intestine, Large ; Kidney ; Lung ; Lymph Nodes ; Mediastinum ; Neoplasm Metastasis* ; Ovary ; Pancreas ; Peritoneum ; Portal Vein ; Skin

Mixed tumor can be defined as arising from the skin, often from sweat glands, and as being composed of epithelial elements intermingled with cartilage or myxoid tissue in such a way that epithelial cells appear to be continuous with these otber types of cells without separation by a basement membrane. RecentIy, we had opportunity to observe a patient, 34-year-old woman, who had typical mixed tumor of the skin in the central portion of the chin. The tumor developed as a solitary, firm, rice-sized subcutaneous nodule which had been present for 6 months with little increase in size and without any pain and tendemess. The covering skin was normal except mild erythema. Clinically, the lesion was simiIar to sebaceaus cyst, Under local anesthesia, tbe whole tumor mass was removed surgically for histologic study. The histopathologic finding reveals nests of cuboidal or polygonal cells, tubuloalveolar and ductal structures, and homogeneous, faintly bluish chondroid or foamy appearing matrix. (Photo. 1, 2, 3 & 4)
Adult ; Anesthesia, Local ; Basement Membrane ; Cartilage ; Chin ; Epithelial Cells ; Erythema ; Female ; Humans ; Skin ; Sweat Glands

No abstract available.
Adult* ; Humans ; Myofibroma*

Hypohidrotic ectodermali dysplasia is a rare and heterogenous genodermatosis that is characterzed by hypohidrosis, hyptrichosis, dental hypoplasia, and a characteristic facies. A 16-month-old male was evaluated for anodontia and anhidrosis since birth. There was no family history of this disease. His face was characterized by a broad nose and sparse eyebrows and periorbital wrirkling. The skin was dry, and scalp hairs were thin and sparse. Skull X-ray finding revealed noth ing remarkable except de;ayed teeth eruption. His developmental status for which we used DDS'I' was slightly reduced on inental development and showed normal on physical development. A skin biopsy was done on skin from the left palm, which showed a few immature eccrine glands in the dermis. We report a typical form of hypohidrotic ectodermal dysplasia with a review of the literature.
Anodontia ; Biopsy ; Dermis ; Eccrine Glands ; Ectodermal Dysplasia 1, Anhidrotic* ; Eyebrows ; Facies ; Hair ; Humans ; Hypohidrosis ; Infant ; Male ; Nose ; Parturition ; Scalp ; Skin ; Skull ; Tooth

The role of the immune system in pathogenesis of skin cancer has been attracted increasing attention in recent years. Some limited studies and observations suggest that altered immune status may be a factor in the initiation and growth of cutaneous malignancies. Authors experienced a typical case of xeroderma pigmentosum in a 6 year-old girl, who has been suffered from hyper and hypopigmented macules on sun-exposed area, photophobia and also noted eroded lesion on the lower lip. The biopsy finding of the hyperpigmented macule showed that of freckle and the finding of actinic cheilitis was observed from the specimen of eroded 1esion on the lower lip. We performed immunologic test and obtained some evidences of immunologic defect; such as decreased numbers of total T cells, T-suppressor cell and B cell in our patient.
Actins ; Biopsy ; Cheilitis ; Child ; Cytochrome P-450 CYP1A1 ; Female ; Humans ; Ichthyosis* ; Immune System ; Immunologic Tests ; Lip ; Melanosis ; Photophobia ; Skin Neoplasms ; T-Lymphocytes ; Xeroderma Pigmentosum*

Pityriasis Rubra Pilaris is a rare, chronic, mildly inflammatory disease characterized by fine acuminate follicular papules with orange-red to salmon-colored scaling of the skin and erythroderma that surround islands of normal, uninvolved skin, particular in the trunk. Most patients also develop palmoplantar hyperkeratosis in the early course of the disease. Focal acantholysis occurring in pityriasis rubra pilaris is an unusual and incidental histologic finding within the spectrum of histologic change of the disease. No case featuring this concomitant histologic finding has been reported in the Korean literatures up to date. We report a case of focal acantholysis occurring in a patient with the clinical features of pityriasis rubra pilaris which may be considered as an incidental finding.
Acantholysis* ; Dermatitis, Exfoliative ; Humans ; Incidental Findings ; Islands ; Pityriasis Rubra Pilaris* ; Pityriasis* ; Skin

We present two cases of pseudocyst of auricle which occured in 59-year-old man and 21-year-old man. Each showed bean sized non-inflammatory cystic swelling of upper part of right auricle with slight tenderness and the cystic content was serosanguinous fluid. Cystic wall was composed of fibrovascular tissue replacing degenerated cartilage without lining epithelium.
Cartilage ; Epithelium ; Humans ; Middle Aged ; Young Adult