No abstract available.
Surgery, Computer-Assisted*

During the Japanese imperialism, an attempt for colonial education in the Korean peninsula was to put into operation of a medical education movement. This plan was set up by the Tong-in club in 1907 and the foundations were laid in Pyong-yang and Tae-gu Tong-in hospitals. This report is a review acheiving the approach that was underplotted with the intention of the colonial education policy. Also, this report centralizes on the objectives of the Tong-in club establishment and the details of the medical education movement in the Korean peninslula. On June 16th, 1902, the Tong-a Don-mun club, Tong-a-mun club, Tong-mun medical club were established under the management of Mr. Irizawa Tatchkiji. The objectives of these clubs were to spread and popularize medical science into the Qing-Dynasty, Choson Dynasty and other countries. Tong-in club practiced modern medicine in the Korean peninsula. With the reason that they were responsible for cultural movement in the colonial region, the Tong-in club stayed in action until the Pacific war ended. Thus, they were playing a role similar to that of a lady-in-waiting in the aggressive war among the Imperialists. The Tong-in club was an organization with 6 main functions; 1) To provide modern medicine, prevent epidemics, maintain a sanitation level and to back up the Doctor Education Movement 2) To publish the Tong-in club's medical magazine 3) To translate and publish Chinese medical books 4) To train and provide seminars to Chinese doctors 5) To encourage communications from Chinese students studying medicine in Japan 6) To examine the standard of the hygiene in China etc. to other things To examine, the Doctor Education Movement in An-dong in the Manchurian region spread to the Chinese and Choson people in the Korean peninsula, also the Doctor Education Movement put into operation in Pyong-yang and Tae-gu. The summary of the An-dong Tong-in club's activities as follows; (1) The activities of An-dong Tong-in hospital educated 21 Koreans and 12 Chinese in 1911, but only 2 Koreans and 1 Chinese were able to graduate from the process. An-dong hospital was at the management by the principal Mr Sakazaki, and was under the pains in finance. (2) The activities of Tae-gu Tong-in hospital started on the 1st of February 1907, and continued till April 1911. Then activities they took over to the institute of medical center in Seoul attached to the Goverment-General in Choson. They educated 30 students every 1st semester and 2nd semester with the principal Mr Ikegami Shhiro as leader but all of them couldn't graduate without falling behind except 5. The contents of education mainly consisted of the Japanese language, preparatory subjects, physics, and anatomy, but they were superficial in depth. Besides that, girl students could be instructed about nursery and childbirth and delivery. And they also trained 40 students majoring in vaccination by the second term. (3) The activities of Pyong-yang Tong-in club was put into operation on December 1906. They made the medical institute attached to public Tong-in hospitals and from the days on October 1907, Mr Sato Kotcho gave his full interest in the education of the medical spheres of Korean students. The medical institute attached to Tong-in hospital had taken over the school of a private-village styled education administered by Mr Nakamura Tomitcho at the Taedong gate street on April 1905. He was the creator of medical education in that region and took a spread and hidden role in the development of medical history in Korea. 15 or 16 medical students were taught the apprentices through an interpreter at a Korean-style house in 1907. The excellent students from the public Japanese school took the role of the interpreters. At that time the Choson government gave 600 won every month to the Pyong-yang and Taegu hospitals. It seemed that the Resident-General Ito Hirobumi gazed with deep interest and anxiety on these hospital's behaviors and progress. The Pyongyang Jahye hospital taking over the former Pyongyang-hospital's duties, had 57 students including 8 seniors, 3 juniors, 6 sophomores, and 36 freshmen. There were 13 students in the nursery department including 6 Korean preparatory students and 5 Japanese and 2 Korean regular students. The first 8 students graduated form the Pyong-yang Jahye hospital in September 1910. They held a medical license without examination and entered the service of the patients at Jahye public hospitals in Won-ju, Chun-chon and Kwang-ju. I think that the projects of medical education starting from Tong-in club disappeared completely under the dictatorship of the Governor-General. It is certain that the Japanese medical education might take a great role in the development of the history in the spheres of Korean medicine. But the Japanese imperialistic government began, with deep interest and anxiety, whether it was really necessary to educate the Korean students in medical spheres. Namely, it seemed that there were many quarrelsome arguments about the necessity of medical education on the Choson colony. But it was paradoxically fortunate, the Tong-in club obtained good results to some extent by keeping the principles of the Residenty-General. It was short terms no more than 3 years but Tong-in club tried to practice the medical education projects, under the name of literally the Same Humanity and Charitly, but it managed to appease the minds of the colonized Korean people. It was the medical education projects in Tong-in club that caused a combat in outpost of the education principles of colony under 'the Same Humanity and Charity between Japan and Choson' at the just end of 3. 1 Movement by the inauguration of Saito Makkot the Governor-General. We can arrive at conclusion that the Japanese colonists tried to approach colonial education through the medical education by following the examples of western-imperialistic countries. The medical education projects of Tong-in club were the basic and continual principles since emerging Choson into Japan as colony. Namely it could be highlighted that the medical education practices of Tong-in club were planned and driven as a part of pervasion of the Japanese colonial education principles, namely 'the Same Humanity and Charity between Japan in Choson'.
Colonialism/*history ; Education, Medical/*history ; English Abstract ; History of Medicine, 20th Cent. ; Japan ; Korea ; Societies/*history

PURPOSE: Thyroid hormone is essential for normal growth and development. The aim of this study was to evaluate the factors affecting final adult height in patients with congenital hypothyroidism. METHODS: The study group was comprised of 42 patients who were diagnosed as congenital hypothyroidism and attained final adult height. Retrospectively, we reviewed medical records as to clinical and laboratory data. We analyzed the influence of various factors on final adult height(FAH) in patients with congenital hypothyroidism. RESULTS: The mean chronologic age at initiation of treatment was 5.85+/-4.32 years and the FAH deviation score(SDS) was -1.21+/-1.14. The age at initiation of treatment, the chronologic age, the mean dose of L-thyroxine of current treatment, and the bone age delay at initiation of treatment were negatively related to the FAH SDS(P<0.05). The height SDS at initiation of treatment and the height SDS at initiation of puberty were positively related to the FAH SDS(P<0.05). Analyzing according to etiology, the FAH SDS of dyshormonogenesis, thyroid aplasia, thyroid ectopia, and thyroid hypoplasia were 0.16+/-0.27, -1.15+/-0.97, -1.45+/-1.07, and -2.70+/-1.70 respectively(P<0.05). CONCLUSION: The younger the age at initiation of treatment and the chronologic age, and the more the mean dose of L-thyroxine of current treatment and the bone age delay at initiation of treatment, The higher the final adult height SDS. The higher the height SDS at initiation of treatment and the height SDS at initiation of puberty, the final adult height SDS were the higher.
Adolescent ; Adult* ; Congenital Hypothyroidism* ; Growth and Development ; Humans ; Medical Records ; Puberty ; Retrospective Studies ; Thyroid Dysgenesis ; Thyroid Gland ; Thyroxine

Purpose : The main genetic contribution to type 1 diabetes susceptibility is the human leukocyte antigen (HLA) class II gene. Several non-HLA chromosomal regions are also known to be involved. We studied the association of HLA class II and non-HLA candidate genes, which are cytotoxic T lymphocyte antigen-4 (CTLA4), tumor necrosis factor (TNF), lymphotoxin-alpha(LT-alpha, and vitamin D receptor (VDR) gene, polymorphisms with disease susceptibility in Korean children with type 1 diabetes.Methods : Fifty Korean children with type 1 diabetes (29 girls and 21 boys) and 166 healthy Koreans were investigated in this study. HLA class II alleles were determined by PCR-SSP (sequence-specific primer) and PCR-SSOP (sequence specific oliogonucleotide probe) method. CTLA4 exon 1 polymor phism was analyzed by PCR-SSCP (single strand conformation polymorphism), and TNF promotor and LT-alphagene polymorphism by PCR-RFLP (restriction fragment length polymorphism), respectively. VDR gene polymorphisms were analyzed by PCR-RFLP using restriction enzyme FokI, ApaI, TaqI, and BsmI. Results : The frequencies of HLA-DRB1*04, DRB1*09, and DQB1*04 were significantly increased and those of HLA-DRB1*14, DRB1*15, DQB1*05 and DQB1*06 were significantly decreased in the patients with type 1 diabetes compared with the control subjects. No significant differences in the distribution of CTLA4 exon 1, TNF promotor, LT-alpha and VDR gene polymorphisms were observed between the patients with type 1 diabetes and the control subjects. Conclusion : These data suggest that HLA-DRB1*04, DRB1*09, and DQB1*04 are susceptible genes for type 1 diabetes, whereas HLA-DRB1*14, DRB1*15, DQB1*05, and DQB1*06 are protective genes in Korean children. CTLA4 exon 1, TNF promotor, LT-alpha and VDR gene polymorphisms are not associated with susceptibility to type 1 diabetes in Korean children.
Alleles ; Child* ; Diabetes Mellitus, Type 1* ; Disease Susceptibility* ; Exons ; Female ; Genes, MHC Class II ; Humans ; Leukocytes ; Lymphocytes ; Receptors, Calcitriol ; Tumor Necrosis Factor-alpha

Premature rupture of membrane is the most frequent cause of low birth weight infant delivery which increase the maternal and fetal morbidity and perinatal mortality. A retrospective case-control study was performed on 315 mothers who delivered low birth weight infants(< or = 2.5kg) with premature rupture of membrane and as control group 546 mothers who delivered normal birth weight infants(2.9-3.7kg) without premature rupture of membrane were chosen. The results obtained from this study were as follows: 1. The proportion of low birth weight infants due to premature rupture of membrane among all low birth weight infant deliveries was 14.5%, and this is equivalent to 1.1% among all deliveries. 2. The most significant maternal risk factor of low birth weight infant deliveries with premature rupture of membrane was infections on vagina, cervix and uterus during pregnancy. Compared with control, adjusted odds ratio was 7.61(95% confidence interval(CI) 1.88-30.88, p=0.004). Other significant maternal risk factors were the history of induced abortion, spontaneous abortion, and the experience of premature delivery. The risk ratios were 1.82, 2.07, 4.42, respectively. 3. Breech presentation did increase the risk of low birth weight infant delivery with infant delivery with premature rupture of membrane against control(Adjusted odds ratio=2.66, 95% CI 1.35-5.26, p=0.005). 4. Mothers who had not taken antenatal care were having higher risk of low birth weight infant delivery with premature rupture of membrane against control(Adjusted odds ratio=1.73, 95% CI 1.35-5.26, p=0.004). These study results show that maternal factors such as the infection of genital organs during pregnancy, the history of induced abortion and breech presentation are significantly associated with the premature rupture of membrane in the low birth weight deliveries, and that most of these risk factors are controllable ones through proper antenatal cares.
Abortion, Induced ; Abortion, Spontaneous ; Birth Weight ; Breech Presentation ; Case-Control Studies ; Cervix Uteri ; Female ; Genitalia ; Humans ; Infant ; Infant, Low Birth Weight* ; Infant, Newborn ; Membranes* ; Mothers ; Odds Ratio ; Perinatal Mortality ; Pregnancy ; Retrospective Studies ; Risk Factors ; Rupture* ; Uterus ; Vagina

The author evaluated the optimal concentration of 3 compositions of TIC medium which has used as the melanacytes culture medium. The concentrations of placental extract and bovine pituitary extract, which have the ability to promote proliferation of melanocytes, were evaluated also. Modified TIC medium with above 5 components of evaluated concentration was very effective in melanocytes culture. The results were as follows : l. 12-0-tetradecanoyl-phorbol-13-acetate (TPA) showed effective melanocytes proliferating activity at the concentration of 30ngml (p(0.05) 2. Isobutylmet:hyl xanthine (IBMX) showed effective melanocytes proliferating activity at the concentration of 0.3mM (p(0.05) 3. Cholera toxin (CT) showed effective melanocytes proliferating activity at the concentration of )OnM (p(0.05) 4. Two percentages of placental extract in culture medium showed effective melanocytes proliferating activity. S. Two percentages of bovine pituitary extract in culture medium showed effective melanocytes proliferating activity. 6. Placental extract and isobutylmethyl xanthine proved to have high melanocytes proliferating activity. 7. Melanocytes proliferated rapidly on modified TIC medium (Proliferation doubling time . about 43 hours) 8. The peak time of melanocytes proliferation (7.2 X 10/cm) was observed on the seventh day of culture, From this data, this culture system can be recommended as a new melanocytes culture.
Cholera Toxin ; Humans* ; Melanocytes* ; Tics ; Xanthine

PURPOSE: Functional MR imaging is the method of demonstrating changes in regional cerebral blood flow produced by sensory, motor, and any other tasks. Functional MR of visual cortex os performed as a patient stares a photic stimulation, so adaptable photic stimulation is necessary. The purpose of this study to evaluate whether the size of photic stimulation can affect the degree of visual cortex activation. MATERIALS AND METHODS: Functional MR imaging was performed in 5 volunteers with normal visual acuity. Photic stimulator was made by 39 light-emitting diodes on a plate ,operating at 8 Hz. The sizes of photic stimulator were full field, half field and focal central field. The MR imager was Siemens 1.5-T Magenton Vision system, using standard head coil. Functional MRI utilized EPI sequence (TR/TE=1.0/51. 0msec, matrix No.=98x128, slice thickness=8mm) with 3sets of 6 imaging during stimulation and 6 imaging during stimulation and 6 imaging during rest, all 36 scanning were obtained. Activated images were obtained using postprocessing software(statistical analysis by Z-zone, and these images were combined with T-1 weighted anatomical images. The activated signals were quantified by numbering the activated pixels, and activation index was obtained by dividing the pixel number of each stimulator size with the sum of the pixel number of 3 study using 3 kinds of stimulators. The correlation between the activation index and the stimulation size was analysed. RESULTS: Mean increase of signal intensities on the activation area using full field photic stimulator was about 9.6%. The activation index was greatest on full field. second on half field and smallest in focal central field in 4, The index of half field was greater than that of full field in 1. The ranges of activation index were full field 43-73%(mean 55%), half field 22-40%(mean 32%), and focal central field 5-24%(13%). CONCLUSION: The degree of visual cortex activation increases with the size of photic stimulator.
Head ; Humans ; Magnetic Resonance Imaging* ; Photic Stimulation ; Visual Acuity ; Visual Cortex* ; Volunteers

No abstract available.
Autonomic Pathways* ; Rectal Neoplasms* ; Urodynamics*

BACKGROUNDS: Obstructive sleep apnea syndrome(OSA) can divided into two groups, positional (PP) and non-positional(NPP) obstructive sleep apnea syndrome, according to the body position while sleeping. In this study, we evaluated the differences of anthropometirc data and polysomnographic recordings between the two types of sleep apnea syndrome. MATERIALS: Fifty patients with OSA were divided two groups by Cartwright's criteria. The supine respiratory disturbance index (RDI) was at least two times higher than the lateral RDI in the PP group, and the supine RDI was less than twice the lateral RDI in the NPP group. This patients underwent standardized polysomnographic recordings. The anthropometirc data and polysomnographic data were analyzed, statistically. RESULTS: Of all 50 patients, 30% were found to be positional OSA. BMI was significantly higher in the PP group(p<0.05). Total sleep time was significantly longer in the PP group (350.6±46.0min, p<0.05). Sleep efficiency was high in the PP group(89.6± 6.4%, 85.6±9.9%, p<0.05). Deep sleep was significantly higher and light sleep was lower in the PP group than in the NPP group but no difference was observed in REM sleep between the two groups. Apnea index(AI) and RDI were significantly lower(17.0±10.6, 28.5±13.3, p<0.05) and mean arterial oxygen saturation was higher in the PP group(92.7 ±1.8%, p<0.05) than in the NPP group. CONCLUSION: Body position during sleep has a profound effect on the frequency and severity of breathing abnormalities in OSA patients. A polysomnographic evaluation for suspected OSA patients must include monitoring of the body position. Breathing function in OSA patients can be improved by controlling their obesity and through postural therapy.
Apnea ; Humans ; Obesity ; Oxygen ; Polysomnography ; Respiration ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive* ; Sleep, REM

Local anesthesia for arthroscopic procedure of the knee is an increasinglv popular technique that avoids the use of general anesthesia and the associated risks of respiratory depression, aspiration, and postoperative sedation. Many authors, for example McGinty etc., Martin, Yoshiya etc., advocated local anesthesia as safe and efficient method for arthroscopic procedures of the knee. We performed arthoroscopy of the knee under local anesthesia on 150 patients for diagnostic and operative purposes between January l993 and December l996. The technique of local anesthesia that we used was that 20cc of 0.5%; bupivacaine with I:200,000 epinephrine was injected into superolateral portal of the knee joint and additional 10-20cc ot 1% lidocaine into the arthroscopic portals. Pnevmatic tourniquet wa, not applied in all cases. We analysed the 150 cases and the results were as follows; The diagnostic arthroscopy was performed in 50 cases and the operative arthroscopy was in 100 cases. The duration ot local anethesia was from 4 hours to 12 hours, with an average of 6 hours. In 35 cases arthroscopy was performed as outpatient procedure and average hospital stay excluding other problem was 5 days. No complication related to systemic toxicity by local anesthetics was observed. Conclusively arthroscopy of the knee under local anesthesia is safe and effective procedure to avoid the risks of general anesthesia but patients selection is very important.
Anesthesia, General ; Anesthesia, Local* ; Anesthetics, Local ; Arthroscopy* ; Bupivacaine ; Epinephrine ; Humans ; Knee Joint ; Knee* ; Length of Stay ; Lidocaine ; Outpatients ; Respiratory Insufficiency ; Tourniquets