1.Rapid Detection of Mycoplasma pneumoniae and Antimicrobial Susceptibilities of the M. pneumoniae Isolates.
Myung Woong CHANG ; Kwang Hyuk KIM ; In Dal PARK ; Kyung Hee KANG ; Eun Hee KONG ; Man Hong JUNG ; Gap Young SONG ; Sung Hwan JO ; Dong Whee CHO ; Byung Ho HAN ; Sung Won KIM ; Chang Hwan OH ; Eun young LEE ; Moon Chan KIM ; Myung Hoon CHO ; Kyu Earn KIM ; Seon Young PARK ; Hyun Jang CHO ; Choong Eon CHOI
Journal of Bacteriology and Virology 2003;33(3):183-191
The throat swabs obtained from 1,098 adults and 432 children patients with respiratory diseases were examined for Mycoplasma pneumoniae infection detected by culture and polymerase chain reaction (PCR). Antimicrobial susceptibilities of the resulting 60 M. pneumoniae isolates were evaluated by testing minimum inhibitory concentrations (MICs) of erythromycin, minocycline, tetracycline, josamycin, sparfloxacin, ofloxacin, and ciprofloxacin by a broth micro-dilution method. In a preliminary screening, the detection rate of M. pneumoniae by PCR was 29.2% (277/948) for the adults and 28.3% (90/318) for the children. In the second survey, the isolation rate of M. pneumoniae by culture was 29.3% (44/150) for the adults, and 14.0% (16/114) for the children. The PCR detection rate was 36.7% (55/150) for the adults and 23.7% (27/114) for the children. The MIC90s of the M. pneumoniae isolates were 0.015 mg/ml for erythromycin, lower than 0.03 mg/ml for josamycin, 0.06 mg/ml for sparfloxacin and minocycline, 0.12 mg/ml for tetracycline, 0.5 mg/ml for ofloxacin and CFC-222, and 1.0 mg/ml for ciprofloxacin. The isolates were susceptible to erythromycin, josamycin, sparfloxacin, minocycline, tetracycline, and ofloxacin, but the 63.3% of them was resistant to ciprofloxacin. These results indicate that the PCR method has a significant potential as a rapid and sensitive method for early detection of M. pneumoniae infection in clinical specimens as compared with the culture method, but the PCR method could not provide any information concerning the biological chracteristics of M. pneumoniae strains. Erythromycin, josamycin, sparfloxacin, minocycline, and tetracycline could be recommended as the antimicrobial agents of choice in Korea.
Adult
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Anti-Infective Agents
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Child
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Ciprofloxacin
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Erythromycin
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Humans
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Josamycin
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Korea
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Mass Screening
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Microbial Sensitivity Tests
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Minocycline
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Mycoplasma pneumoniae*
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Mycoplasma*
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Ofloxacin
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Pharynx
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Pneumonia*
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Pneumonia, Mycoplasma*
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Polymerase Chain Reaction
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Tetracycline
2.Clinical Outcome of Acute Bacterial Prostatitis, a Multicenter Study.
In Rae CHO ; Keon Cheol LEE ; Seung Eon LEE ; Joon Seong JEON ; Seok San PARK ; Luck Hee SUNG ; Choong Hee NOH ; Won Jae YANG ; Young Deuk CHOI ; Sung Joon HONG ; Seung Choul YANG ; Jin Seon CHO ; Hyun Soo AHN ; Se Joong KIM ; Hong Sup KIM ; Ki Hak SONG ; Do Hwan SEONG ; Jun Kyu SUH ; Kyung Seop LEE ; Yun Seob SONG ; Dong Hyeon LEE ; Young Sig KIM
Korean Journal of Urology 2005;46(10):1034-1039
PURPOSE: Few studies have examined acute prostatitis in Korea. To initiate the investigation of this topic, a multi-center retrospective analysis of acute prostatitis was conducted. MATERIALS AND METHODS: The clinical records of 335 patients from 13 hospitals, diagnosed with acute prostatitis, between January of 1994 and October of 2004, were reviewed. For each patient, the urine culture, changes in the PSA (prostate-specific antigen) value and the prostate volume, the incidence of prostate abscess, the use of antibiotics, and whether the disease went into remission or progressed to chronic prostatitis were analyzed. RESULTS: The mean age of the patients, time from the onset of symptom to admission and number of days of admitted were 54.9+/-15.1 (16-85) years, 2.4+/-3.4 (16-85) days and 7.5+/-3.9 (1-25) days, respectively. The chief symptoms of the patients were high fever, dysuria and urinary frequency. Routine urinalysis found pyuria in 82% and hematuria in 70% of patients. The causative organisms of 43.0% of the patients were cultured, with the chief organisms found to be E. coli (67%) and P. aeruginosa (13%), et al. The mean PSA and prostate volume on initial diagnosis were 24.6+/-30.2ng/ml and 45.8 +/-17.4ml, respectively, and a prostate abscess was found in 4 patients (3.1%). The antibiotics injected during patient admission were: cephalosporin family (68%), aminoglycosides (70%) and quinolone family (43%). An additional alpha blocker was used in 49% of cases. Oral quinolone (91%), cephalosporin (9%) and alpha blocker (44%) were prescribed for a mean 32.5 (2-180) days after discharge. 259 (77%) of the patients were available for follow-up. Of these, 21% took antibiotics over an 8 week treatment period, and 8% over a 12 week period. The disappearance of pyuria after treatment was observed in a mean of 13 days after the end of treatment. After 13 weeks of treatment, 11 (50%) of the 22 patients who received prostate massage (4.2% of all follow up patients) were found to have chronic prostatitis. The mean PSA and prostate volume declined during follow up, to 6.13+/-10.38ng/ml and 37.5+/-13.5ml, respectively. CONCLUSIONS: In our study, the most common chief symptom of acute prostatitis was a high fever, with the most common causative organism being E. coli. Patients were admitted for approximately one week, and treated with antibiotic for about one month, after which time PSA elevation was observed in 80% of patients. Although all acute prostatitis patients were treated with proper antibiotics, progression to chronic prostatitis was observed in 4.2% of patients.
Abscess
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Aminoglycosides
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Anti-Bacterial Agents
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Diagnosis
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Dysuria
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Fever
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Follow-Up Studies
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Hematuria
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Humans
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Incidence
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Korea
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Massage
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Patient Admission
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Prostate
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Prostate-Specific Antigen
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Prostatitis*
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Pyuria
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Retrospective Studies
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Urinalysis
3.Comparative Analysis of Clinical Parameters in Acute Pyelonephritis.
Yon Hwan JUNG ; In Rae CHO ; Seung Eon LEE ; Keon Cheol LEE ; Jong Gu KIM ; Joon Seong JEON ; Seok San PARK ; An Sik ROH ; Won Jae YANG ; Luck Hee SUNG ; Jae Yong JUNG ; Choong Hee NOH ; Jae Il CHUNG ; Kweon Sik MIN ; Dong Il KANG ; Seung Hyup CHOI ; Duk Yoon KIM ; Sang Don LEE ; Hong Sup KIM ; Dong Hyun LEE ; Do Hwan SEUNG ; Young Seop CHANG ; Ki Hak SONG ; Kyung Seop LEE ; Dong Soo PARK ; Young Ho KIM ; Min Eui KIM
Korean Journal of Urology 2007;48(1):29-34
PURPOSE: To compare the variable inflammatory parameters of acute pyelonephritis patients treated with inpatient therapy at 13 hospitals, according to the age and gender distributions. MATERIALS AND MATHODS: A total of 3,544 medical records of patients with confirmed acute pyelonephritis, and admitted to hospital between January 2000 and December 2005, were retrospectively analyzed. RESULTS: The mean age of the patients was 43.2+/-16.2 years old, with a male:female ratio of 1 : 5.1. The average duration of hospital admission was 7.9+/-5.3 days. Underlying diseases were found in 23.0% (749/3,252 patient), largely due to diabetes (35.1%). Radiological abnormal findings were found in 13.7%. The leukocyte count, ratio of segmented form, erythrocyte sedimentation rate (ESR), c-reactive protein, pyuria, positive blood culture, positive urine culture were 11,014+/-5,778/mm(3), 74.8+/-14.5%, 44.0+/-32.0 mm/hr, 12.4+/-9.3mg/dl, 83.9%, 10.5% and 46.7%, respectively. E. coli grow in 79% of the urine culture positive patients. In a comparison of 3 age groups (<40 years, 40-60 years, >61 years), the elderly patients had a greater number of underlying diseases and more pathogens in cultured blood. When divided into males and females, the elderly male patients had more pathogen in cultured urine, but contrary to the male patients, the elderly female patients had elevated leukocyte count and erythrocyte sedimentation rate. Also, the old patient group had more resistance to ampicillin when they had E. coli as the uropathogen (p=0.021). Patients with higher ESR required longer hospital admission periods. CONCLUSIONS: It was found that variable clinical parameters of acute pyelonephritis patients treated with inpatient therapy differed according to both gender and age group in Korea. Therefore, these factors should be taken into account in the treatment plan.
Aged
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Ampicillin
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Blood Sedimentation
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C-Reactive Protein
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Female
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Humans
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Inpatients
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Korea
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Leukocyte Count
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Male
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Medical Records
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Pyelonephritis*
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Pyuria
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Retrospective Studies