No abstract available.
Osteoblasts*

No abstract available.
Magnetic Resonance Imaging*

No abstract available.
Doxorubicin* ; Drug Therapy* ; Small Cell Lung Carcinoma*

No abstract available.

The usual causes of unilateral lower extremity swelling after total hip arthroplasty include deep vein thrombosis, chronic venous insufficiency and less frequently an infection or a neoplasm. Unilateral deep vein thrombosis or swelling of the lower extremity due to an intrapelvic granulomatous mass after total hip arthroplasty is quite unusual. We report a rare case of a patient with an intrapelvic granulomatous mass causing deep vein thrombosis and unilateral lower leg swelling after total hip arthroplasty with a review of the relevant literature.
Arthroplasty ; Hip ; Humans ; Leg ; Lower Extremity ; Venous Insufficiency ; Venous Thrombosis

Parathyroid hormone(PTH), a major bone hormone, inhihits DNA and collagen syntheses in osteohlast-like cells in vitro, but increase the proliferation of osteoblast in vivo as secn in hyperparathyroidism. On the other hand, insulin is known to increase DNA and collagen syntheses and modify the effects of PTH in osteoblast-like cells. We have examined the effects of PTH and insulin in rat osteosarcoma UMR-l06-01 cells and whether PTH plays a role in the insulin-mediated bone formation. When 1 nM PTH and 10 nM insulin were administered to VMR-l06-01 ceils, the rates of DNA synthesis were 124% and 136% of the untreated control, respectively. When the two hormones were administered serially by exposing to 1 nM PTH for 7 days followed by 10 nM insulin lor 24h, the largest increase was observed. The protein synthesis was also increased remarkahly when the two hormones were aclministered serially: the[3H]-leucine incorporation rates, compared to the control group, were 75% and l62% with PTH ancl insulin administration, respectively, but the rate was 297% with the serial administration of the two. The collaeen synthesis, as measured by the (3H)-proline incorporation rates were 60% and l64% with PTH and insulin administration, respectively, but 351% with serial administration, again showing a dramatic effect. These results showed that 1 nM PTH decreased DNA and collagen syntheses in UMR-l06-01 cells after both a 24h and a more prolonged exposure. Similar exposures to insulin tended to increase the syntheses. The comhination of PTH and insulin tended to increase the syntheses. hut not beyond the effect of insulin alone. However, the sequential administration of PTH and insulin markedly increases ihose rales relative to the simultaneous adminstration of these two hormones. Thus, it is possihle that sequential stimulation of PTH and insulin in hone matrix exerts an synergistic effect on hone formation in vivo.
Animals ; Collagen ; DNA ; Hand ; Hyperparathyroidism ; Insulin* ; Osteoblasts ; Osteogenesis ; Osteosarcoma* ; Parathyroid Hormone* ; Rats ; Respiratory Sounds

Osteoclasts resorb bone by the hydrogen ions and proteolytic enzymes in the localize environment under the ruffled border. Before releasing hydrogen ion and enzymes, osteoclast should attach to bone surface very tightly and make a room to release enzymes and hydrogen ion in the center. Specialized attachment molecule in the cell membrane, such as integrin, is associated with specific noncollagenous protein in the matrix, which has specific amino acid sequence (Arginine-Glycine- Aspartic acid sequence). We may speculate that osteoclast action would be decreased if the integrin is blocked by antibody or RGD protein. In this study, the osteoclasts were cultured on the coverslip or bone slice with or without RGD protein in the culture medium, and numbers of growing giant cells were much less in group with RGD protein. The number resorption pits, formed on mineralized bone slice, was also lower in the group adding RGD protein in the medium. And we made a conclusion that the osteoclastic bone resorption was inhibited by soluble RGD protein.
Amino Acid Sequence ; Aspartic Acid ; Bone Resorption ; Cell Membrane ; Giant Cells ; Osteoclasts* ; Peptide Hydrolases ; Protons

PURPOSE: To analyze complications and their effects on prognoses of children hip fractures. MATERIALS AND METHODS: 26 childhood hip fractures (6 type I, 7 type II, 10 type III, 3 type IV) were studied for 11 years (1986-1997) . We analyzed factors possibly related to complications and their effects on prognoses, especially avascular necrosis (AVN) of the femoral head. RESULTS: Of 26 patients, there were 7 AVN (27%) , 2 nonunions (8%) , 3 coxa vara (12%) , 9 premature epiphyseal closures (35%) , and 2 infections (8%) . Of 7 patients with AVN, 3 patients had type I fracture and 4 patients had type II fracture. No AVN developed in type III and IV fractures. Of 2 patients who had type I fracture with dislocation, all patients had AVN (100%) . Four of 14 patients who had displacement of the fracture site and one in 10 patients who had non-displacement fracture developed AVN. In our study of the incidence of AVN according to surgical reduction time after injury, 3 (60%) of 5 patients who were treated by surgical reduction within 6 hours and 4 (19%) out of 21 patients who were treated by surgical reduction after 6 hours developed AVN. CONCLUSION: In childhood hip fracture, surgical reduction time after trauma (<6 hours) did not seem to be a critical factor in preventing AVN. Force of injury and level of fracture site which jeopardize the blood supply to the femoral head were important factors. Age at time of injury was also important. Containment treatment of younger children (<10 years) and surgical treatment of older children (>10 years) were found to be an effective treatment of AVN. AVN concomitant with pyogenic infection had the worst prognosis.
Child* ; Containment of Biohazards ; Coxa Vara ; Dislocations ; Head ; Hip Fractures ; Hip* ; Humans ; Incidence ; Necrosis ; Prognosis

No abstract available.
Knee*

An enlarged iliopsoas bursa caused by hip joint disease, such as osteoarthritis, rheumatoid arthritis, synovial chondromatosis, pigmented villonodular synovitis and septic arthritis, but rarely due to osteonecrosis of the femoral head have been documented. We experienced a rare case of an enlarged iliopsoas bursa associated with osteonecrosis of the femoral head, and drained the iliopsoas bursa through an anterior capsule during total hip arthroplasty, using a posterior approach. We describe this rare case, with a review of the literature.
Arthritis, Infectious ; Arthritis, Rheumatoid ; Arthroplasty, Replacement, Hip ; Chondromatosis, Synovial ; Head* ; Hip Joint ; Osteoarthritis ; Osteonecrosis* ; Synovitis, Pigmented Villonodular