Objective To explore the general rules and characteristics of adverse reactions induced by atorvastatin,and to provide reference for clinical rational use of drugs.Method A retrospective analysis was made on the statistics and analysis of the ADR report forms collected in Fujian Changle Hospital from January 2008 to May 2016.Results The adverse reactions induced by atorvastatin were 52 cases.The number of adverse reactions was up to a maximum of hepatobiliary system damage 22 times (37.29％),gastrointestinal system damage 11 times (18.64％),systemic damage 5 times (8.47％),musculoskeletal system damage 5 times (8.47％),myocardium,endocardium,pericardial and valvular damage 4 times (6.78％),auditory and vestibular function damage 4 times (6.78％).Conclusion The clinical application of atorvastatin should be strengthened in order to reduce the occurrence of adverse reactions.