White & Black Tablet is a kind of over-the-counter drugs commonly used in the treatment of common cold, excessive use may cause poisoning symptoms, the light symptom can be cleared without treatment, the serious manifestation is the appearance of central nervous system signs and symptoms, and even the most serious one may die of respiratory or/and circulatory failure. Our department recently admitted a patient with acute "White & Black Tablet" poisoning leading to ataxia syndrome, and the diagnosis and treatment experiences of this case were summarized in this report.