Objective? To explore the correlation among nurses' comfort with touch, job stressors and job burnout in postpartum nurses with the second-child,and to provide evidence for nursing managers to formulate and implement humanized and scientific management plans. Methods? By convenience sampling, postpartum nurses with the second-child back to work in 6 Class Ⅲ Grade A hospitals in Wenzhou from February 2017 to July 2018 were selected as the research objects. Self-designed General Information Questionnaire, Nurses' Comfort with Touch Scale(NCTS),Chinese Nurses' Work-Stressor Scale(CNSS), Chinese version of Maslach Burnout Inventory General Survey(MBI-GS) were used in the study. Totally 125 questionnaires were distributed and 119 valid ones were retrieved, yielding an effective recovery rate of 95.2%. Results? The 119 postpartum nurses back to work achieved a total score of (43.56±6.09) in NCTS, (535.58±245.96) in CNSS, (25.87±10.43)in the "job burnout" dimension in Chinese version of MBI-GS, (8.96±6.03) in"depersonalization" and (30.12±8.67)in "personal sense of achievement". Pearson correlation analysis indicated that, the returning postpartum second-child nurses' scores of "emotional burnout", "depersonalization" and"work stressors" were negatively correlated with the score of "comfort with touch"(P＜ 0.05), the "personal sense of achievements" was positively correlated with "comfort with touch" (P＜0.01). Multivariate regression analysis showed that emotional burnout, nurses' job stressors, whether receive special care from departments, and income satisfaction were the influencing factors of nurses' touch comfort. Conclusions? Touch comfort is related to job stress and job burnout in the postpartum second-child nurses back to work. Nursing managers should formulate and implement corresponding management training programs according to the characteristics of them, and give more care and support to improve their work enthusiasm and work efficiency.