1.Method and Practice of Operation and Management Improvement in Clinical Department of Public Hospitals
Chongwei XU ; Junxue SHEN ; Liai ZOU
Chinese Health Economics 2013;(10):66-67
There is room for improvement in the clinical department operation of public hospitals. Therefore, through exampling the practice of a public hospital’ s clinical department, to propose the methods in improving the department management.
2.Effect and safety of ultrasound-guided injection of poly-alcohol on patients with scar pregnancy
Xiaohang XU ; Guirong LIU ; Lijun HE ; Chongwei WANG ; Xia ZHAO
Chinese Journal of Biochemical Pharmaceutics 2017;37(8):165-167
Objective To investigate the efficacy and safety of ultrasound-guided polyglycol in patients with scar pregnancy. Methods Thirty-six patients with scarring treated in Third People's Hospital of Hangzhou from November 2014 to November 2016 were selected as subjects. All patients underwent ultrasound-guided polyglycol administration. The results were analyzed and analyzed. The results were analyzed. Gonadotropin (β-HCG) returned to normal time and the occurrence of adverse symptoms. Results The average recovery time, treatment cost, average recovery time and adverse reaction rate of blood β-HCG in the study group were lower than those in the control group, the difference was statistically significant (P<0.05). Conclusion The effect of ultrasound on the injection of polyphenols in patients with scar pregnancy is safe, feasible and easy to be accepted by patients and their families. It has clinical significance.
3.Investigation on clinical curative effect of Compound Shajiziyou Suppository for cervical erosion
Zulan QIU ; Chongwei XU ; Xiangdong RONG ; Mingqing DING
Chinese Traditional Patent Medicine 1992;0(05):-
Objective: To investigate the clinical curative effect of Compound Shajiziyou Suppository (Oleum Hippophae, Fructus Cnidii, Radix Sophorae Flavescentis, Calamina, Resina Olibani, etc.) on cervical erosion. Methods: 212 patients suffering from cervical erosion were treated with 1 piece of Compound Shajiziyou Suppository in vaginal fornix everyday after menstruation, 7 sessions constituting a single therapeutic course. Results: The effective rate during the first therapeutic course was 82.08%. The total effective rate during two therapeutic courses was 94.81%. The curative effect for the mild cervical erosion was better than for the moderate and severe cervical erosion(P
4.Illuminate hepatobiliary and pancreatic surgery using optical molecular imaging methods
Chongwei CHI ; Hongguang WANG ; Yinzhe XU ; Wenwen ZHANG ; Yamin MAO ; Kun WANG ; Jie TIAN ; Shichun LU
Chinese Journal of Hepatobiliary Surgery 2017;23(11):735-740
Since the concept of molecular imaging was put forward in 1999,optical molecular imaging techniques have been widely applied in the field of biomedical and clinical research.Its unique application value is especially shown in hepatobiliary surgery,such as in liver tumor imaging,anatomical liver resection,liver transplant angiography,cholangiography,and bile or pancreatic leakage prevention.Optical molecular imaging technique "lights up" targeted areas in surgical operations and provides convenience in carrying out precision operation.This paper reviewed the advantages of optical molecular imaging technology in clinical research and discussed its limitations in translational surgery,and put forward possible directions in improvement for the future.
5.Effect of telmisartan on expression of metadherin in the kidney of mice with unilateral ureter obstruction.
Fenfen PENG ; Hongyu LI ; Bohui YIN ; Yuxian WANG ; Yihua CHEN ; Zhaozhong XU ; Chongwei LUO ; Haibo LONG
Journal of Southern Medical University 2019;39(2):156-161
OBJECTIVE:
To explore the effect of telmisartan on the expression of metadherin in the kidney of mice with unilateral ureter obstruction.
METHODS:
Eighteen male C57 mice were randomized into sham-operated group, model group and telmisartan treatment group. In the latter two groups, renal interstitial fibrosis as the result of unilateral ureter obstruction (UUO) was induced by unilateral ureteral ligation with or without telmisartan intervention. Renal pathological changes of the mice were assessed using Masson staining, and immunohistochemistry and Western blotting were used to detect the expression of extracellular matrix proteins and metadherin in the kidney of the mice. In the experiment, cultured mouse renal tubular epithelial cells (mTECs) were stimulated with transforming growth factor-β1 (TGF-β1) and transfected with a siRNA targeting metadherin, and the changes in the expressions of extracellular matrix proteins and metadherin were detected using Western blotting.
RESULTS:
The expressions of extracellular matrix proteins and metadherin increased significantly in the kidney of mice with UUO ( < 0.05). Intervention with telmisartan significantly lowered the expressions of extracellular matrix proteins and metadherin and alleviated the pathology of renal fibrosis in mice with UUO ( < 0.05). In cultured mTECs, siRNA-mediated knockdown of metadherin obviously reversed TGF-β1-induced increase in the expressions of extracellular matrix proteins and metadherin.
CONCLUSIONS
Telmisartan can suppress the production of extracellular matrix proteins and the expression of metadhein to attenuate UUO-induced renal fibrosis in mice.
Angiotensin II Type 1 Receptor Blockers
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Animals
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Antihypertensive Agents
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Extracellular Matrix Proteins
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metabolism
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Fibrosis
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Kidney
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drug effects
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metabolism
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pathology
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Male
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Membrane Proteins
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genetics
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metabolism
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Mice
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Mice, Inbred C57BL
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RNA, Small Interfering
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Random Allocation
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Telmisartan
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pharmacology
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Transforming Growth Factor beta1
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pharmacology
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Ureteral Obstruction
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complications
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metabolism