Objective To investigate the cognitive functions in first-degree relatives of patients with schizophrenia by meta-analysis. Methods Collect case-control studies of cognitive function in first-degree relatives of patients with schizophrenia,then extract data and assess the risk of bias of included studies,and use RevMan 5.3 to perform meta-analysis. Results A total of 27 studies involving 1708 people were includ-ed. Trail Marking A test(MD=3.59,P<0.01) and B test (MD=12.71,P=0.02),Stroop Color test((MD=-7.22,P<0.01),Stroop Color-Word test(MD=-7.25,P<0.01),Digit Symbol Coding test(MD=-7.29,P<0.01),Digit Span test(MD=-1.17,P<0.01),Hopkins Verbal Leaning test-Revised(MD=-4.58,P<0.01), Verbal Fluency test(MD=-2.92,P<0.01),Hanoi Tower(MD=-5.38,P<0.01),the number of corrected of WCST(MD=-3.10,P<0.01),number of completed categories of WCST (MD=-0.74,P<0.01),Persevera-tive Errors of WCST (MD=4.82,P<0.01) and Nonperseverative Errors of WCST (MD=8.00,P<0.01) scores between the first-degree relatives groups(FDR)and health control groups (HC)showed significant differences. Conclusion Cognitive impairment appears in the first-degree relatives populations of patients with schizophrenia,including the attention,verbal learning,working memory,and executive function.

Objective To understand the status and influencing factors of kinesiophobia in patients with diabetic peripheral neuropathic pain(DPNP).Methods From February to June 2023,192 patients with DPNP in a tertiary general hospital in Nanchang City,Jiangxi Province were selected by convenience sampling method.The patients were investigated by the demographic information questionnaire,Tampa Scale for Kinesiophobia,Numerical Rating Scale,Medical Coping Modes Questionnaire,Diabetes Distress Scale,and Summary of Diabetes Self-care Activities.Multiple linear regression were used to analyze the influencing factors of kinesiophobia in patients with DPNP.Results The score of kinesiophobia in patients with DPNP was(36.68±3.88),and the incidence of kinesiophobia was 38.5％.Multiple linear regression analysis showed that marital status,pain level,coping style,diabetic distress and self-management behavior were influential factors for kinesiophobia in patients with DPNP(all P＜0.05).Conclusion Patients with DPNP have a moderate level of kinesiophobia.Nursing staff should pay attention to the early assessment of patients'kinesiophobia,promptly identify and take effective measures to reduce the level of patients'kinesiophobia,increase their motivation to exercise,and improve their prognosis and quality of life.