Objective? To explore the effects of follow-up management on blood pressure and glomerular filtration rate (GFR) in patients with chronic kidney disease (CKD). Methods? Totally 660 CKD patients who established health records from June 2016 to June 2017 and received regular follow-up management in the Follow-up Management Center for CKD, West China Hospital, Sichuan University were selected by convenient sampling in this self-control study. The patients received follow-up management for CKD for 12 months and their blood pressure and GFR were measured before and after the follow-up. Results? After the 12-month follow-up, the patients' systolic pressure and diastolic pressure were (126.76±16.35) mmHg and (77.85±10.84) mmHg respectively, both lower than those before the follow-up (t=42.7, 56.2; P＜0.05). The patients' GFR decreased 2.86 ml/min·1.73m2, whose falling range was better than the average level in China. Conclusion? Follow-up management for CKD can effectively reduce the patients' blood pressure and delay the progress of their renal function, which is worth promoting in clinical practice.