1.Assessment of Early Diastolic Left Ventricular Relaxation in Patients with Valvular Regurgitation(with Reference to Incremental Delta Elastance).
Chong Hun PARK ; Young Woo LEE
Korean Circulation Journal 1984;14(1):7-15
Early diastolic left ventricular relaxation was determined in 20 patients by combined echopressure measurement. 7 normal control cases and 13 cases with valvular regurgitation were studied with reference to incremental delta elastance. The hemodynamic and echocardiographic data were analysed during the phase of decreasing left ventricular elastance (that is, when pressure is decreasing while volume is increasing). Starting from a fixed level of wall stress (40 kdyne/cm2), we determined Incremental Delta Elastance(ratio big up tri, Delta p/big up tri, Delta V) by a constant increase in LV volume(eg. 10 ml/M2 or 20 ml/M2). We named Incremental Delta Elastance at 10 ml/M2 and 20 ml/M2 of LV volume increase as d-E 10 and d-E 20 respectively. In valvular regurgitation, incremental delta elastances were statistically different from those of normal subjects(p<0.01). d-E10 was -1.67+/-0.69(versus -3.38+/-1.75 in normal subjects) mmHgm2/ml and d-E20 was -0.98+/-0.39(versus -1.69+/-0.84 in normal subjects) mmHgm2/ml. d-E 10 and d-E20 were compared with ejection phase indices(ejection fraction, meanVcf) in whole group(n=20). There was significant correlation between d-E and ejection fraction(d-E10 : r=-0.47, d-E20:r=-0.50) p<0.05. There was significant correlation between d-E and meanVcf(d-E10: r=0.53, d-E20: r=-0.57) p<0.05. d-E10 and d-E20 were compared with volume indices(end-diastolic volume index and end-systolic volume index) but no significant correlation was found. Because we evaluated that inotropic state or afterload would influence incremental delta elastance, further study, especially with reference to endsystolic volume index may be needed. The absolute values between d-E10 and d-E20 were different but they were simliar in property. We concluded that incremental delta elastance(d-E10 or d-E20) could be used as a useful index of early diastolic relaxation in chronic valvular regurgitation.
Echocardiography
;
Hemodynamics
;
Humans
;
Relaxation*
2.Study on Left Ventricular Contractility in Chronic Valvular Heart Disease of Various Volume Load: With Reference to End Systolic Pressure-Volume, Stress-Volume Relations.
Chong Hun PARK ; Young Woo LEE
Korean Circulation Journal 1984;14(2):215-234
Authors analysed systolic pressure-volume-stress relations by combined echo-pressure-cineangiographic measurement in 10 normal subjects(Group I) and 37 patients with chronic valvular heart diseases. Patients with chronic valvular heart diseases were divided into 3 groups : Group II ; mitral stenosis(n=9), Group III ; mitral stenosis with aortic regurgitation(n=19). The aims of this study are to find useful left ventricular(LV) contractility indices and evaluate left ventricular contractility at various volume loading states. Studied LV contractility indices were maximal elastance of isovolumic contraction(Eiso), endsystolic pressure-volume ratio(Ees) and slope of regression line in late systolic stress-volume loop(A). Eiso was estimated using an isovolumic contraction model of Sunagawa and A was analysed in a single ejecting beat. Endsystolic volume index(ESVI), end diastolic volume index(EDVI), stress at peak pressure(Speak), cardiac index, Vmax, mean Vcf and ejection fraction were determined also. The obtained results were as follows. 1) Significant correlations were found in whole group(n=47) between Eiso and Ees(r=0.88, P<0.005), Elso and cardiac index(r=0.83, P<0.005), Ees and CI(r=<0.76, p<0.005). Further, these correlation coefficiencies were not different between any two groups of Group I, Group II, Group III, Grouop IV and whole group (p<0.05); that is Eiso or Ees had a constant significance at various loading state. 2) Significant correlation between A and cardiac index was noted in Group I+II+III(n=28, r=0.48, p<0.01), but this correlation coefficiency was significantly different from that of Group IV(n=19, r=0.08); p<0.05. 3) In Group II(patients with mitral stenosis), cardiac index* and EDVI* and stress at peak pressure** were decreased significantly(*:p<0.05, **:p<0.005). But Eiso, Ees, A and all the other idices were not decreased. These findings suggested that left ventricular contractility is not reduced in mitral stenosis. 4) In Group IV(patients with amitral regurgitation with or without aortic regurgitation), **EDVI and ESVI** were increased while Eiso**, Ees, Vmax*, mean Vcf* and cardiac index** were decreased significantly. But ejection fraction and A were not decrease. These findings suggested that ejection fraction and A may not be decreased at volume overload, despite of impaired left ventricular contractility. In summary; Eiso or Ees was evaluated as an useful contractility index which appeared not to be influenced by various volume loading state, while eiection fraction and A to be influenced. Patients with mitral stenosis as a group have reduced cardiac performance which is not due to impairment of left ventricular contractility(muscle function) but to reduced preload.
Constriction, Pathologic
;
Heart Valve Diseases*
;
Humans
;
Mitral Valve Stenosis
3.Psychopathological consideration on the hallucinations of schizophrenics by Hutt adaptation of Bender-Gestalt test and mini-mental test.
Chong Ho PARK ; Kuy Haeng LEE ; Sang Woo OH
Journal of Korean Neuropsychiatric Association 1992;31(2):258-266
No abstract available.
Bender-Gestalt Test*
;
Hallucinations*
4.Fracture of ring apophysis of lumbar vertebral body.
Byeong Mun PARK ; Chong Hyuk CHOI ; Woo Suk LEE
The Journal of the Korean Orthopaedic Association 1993;28(5):1588-1594
No abstract available.
5.Study of Serum Lipids and Lipoprotein in Patients with Nephrotic Syndrome.
Eui Soo PARK ; Jeh Hoon SHIN ; Woo Gill LEE ; Chong Moo PARK
Journal of the Korean Pediatric Society 1983;26(4):349-357
No abstract available.
Humans
;
Lipoproteins*
;
Nephrotic Syndrome*
6.Urine Sediments and Protein in Healthy Newborn Infants.
Jeh Hoon SHIN ; Eui Soo PARK ; Woo Gill LEE ; Chong Moo PARK
Journal of the Korean Pediatric Society 1983;26(12):1159-1167
No abstract available.
Humans
;
Infant, Newborn*
7.Safety and Immunogenicity of Live Attenuated Varicella Virus Vaccine(MAV/06 Strain).
Young Mo SOHN ; Chong Young PARK ; Kyu Kye HWANG ; Gyu Jin WOO ; Song Yong PARK
Journal of the Korean Pediatric Society 1994;37(10):1405-1413
We immunized sixty two healthy subjects with the five different viral titers (300, 500, 1000, 1500 and 2000 plaque forming unit; pfu) of the MAV/06 strain of live attenuated Varicella-zoster virus (VZV) in order to gain sufficient information on safety and immuogenicity as a vaccine strain. Humoral immunity of all vaccine recipients was tested by the fluorescent antibody to membrane antigen (FAMA) assay and Enzyme-linked immunosorbent assay (ELISA) for the quantitative detection of IgG antibody. We tested neutralized antibody in 62 subjects by plaque reduction neutralization test (PRNT50). All of thirty two subjects with initial seronegative response had antibody by FAMA method at four weeks after immunization with four different preparations of dosage. The geometric mean titers (GMTs) of VZV antibody to membrane antigen was 160.9 in 6 subjects with 1500 pfu group; 83.3 in 14 subjects with 1000 pfu group: 116.2 in 7 subjects with 500 pfu groups and 72.0 in 6 subjects with 300 pfu group. Thirty subjects who had VZV antibody at the time before immunization demonstrated elevated antibody titer by FAMA assay and PRNT50 test. Side reactions of the vaccination was not demonstrated in all cases.
Chickenpox*
;
Enzyme-Linked Immunosorbent Assay
;
Herpesvirus 3, Human
;
Immunity, Humoral
;
Immunization
;
Immunoglobulin G
;
Membranes
;
Neutralization Tests
;
Vaccination
8.Renal Blood Flow in Chronic Glomerulonephritis.
Chong Woong MOON ; Wee Hyun PARK ; Si Rhae LEE ; Hyun Woo LEE ; Hi Myung PARK
Korean Circulation Journal 1973;3(1):39-43
Renal blood flow was measured by single injection technique of HippuranI13 in 13 patients with chronic glomerulonephritis and 11 control subjects. There was a significant decrease in renal blood flow in chronic glomerulonephritis particulary in those with elevated blood urea nitrogen. Renal blood flow was inversely proportionate to renal vascular resistance but no correlation was noted between renal blood flow and creatinine clearance.
Blood Urea Nitrogen
;
Creatinine
;
Glomerulonephritis*
;
Humans
;
Renal Circulation*
;
Vascular Resistance
9.Detection of Herpes Virus-6 by PCR I Cerebrospinal Fluid from Hospitalized Adult Patients with Aseptic Meningitis or Encephalitis.
Hae Kyung PARK ; So Youn WOO ; Hyun Jin KIM ; Young Hae CHONG
Journal of the Korean Society of Virology 2000;30(3):171-178
No Abstract Available.
Adult*
;
Cerebrospinal Fluid*
;
Encephalitis*
;
Humans
;
Meningitis, Aseptic*
;
Polymerase Chain Reaction*
10.Change of Clinical Feature of Typhoid Fever in Children.
Sung Oh KIM ; Yong Joo KIM ; Woo Kill LEE ; Chong Moo PARK
Journal of the Korean Pediatric Society 1988;31(5):566-576
No abstract available.
Child*
;
Humans
;
Typhoid Fever*