1.Clinical and bacteriological studies of urinary tract infection in children with gastrointestinal symptoms.
Soo Hyeon CHO ; Chong Tae BAK ; Jong Seung JUNG
Journal of the Korean Academy of Family Medicine 1993;14(4):221-231
No abstract available.
Child*
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Humans
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Urinary Tract Infections*
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Urinary Tract*
2.Functions of PIWI proteins in spermatogenesis.
Chong Won BAK ; Tae Ki YOON ; Youngsok CHOI
Clinical and Experimental Reproductive Medicine 2011;38(2):61-67
Recently, a significant understanding of the molecular mechanisms regulating spermatogenesis has been achieved utilizing small RNA molecules (small RNAs), including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs) which emerged as important regulators of gene expression at the post-transcriptional or translation level. piRNAs are only present in pachytene spermatocytes and round spermatids, whereas miRNAs are expressed abundantly in male germ cells throughout spermatogenesis. This review is aimed at providing a glimpse of piRNAs and their interacting family proteins such as PIWIL1, PIWIL2, and PIWIL4 in spermatogenesis.
Animals
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Gene Expression
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Germ Cells
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Humans
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Infertility
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Male
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Mice
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MicroRNAs
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Proteins
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RNA
;
RNA, Small Interfering
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Spermatids
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Spermatocytes
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Spermatogenesis
3.Development, Translation and Validation of Enhanced Asian Rome III Questionnaires for Diagnosis of Functional Bowel Diseases in Major Asian Languages: A Rome Foundation-Asian Neurogastroenterology and Motility Association Working Team Report.
Uday C GHOSHAL ; Kok Ann GWEE ; Minhu CHEN ; Xiao R GONG ; Nitesh PRATAP ; Xiaohua HOU ; Ari F SYAM ; Murdani ABDULLAH ; Young Tae BAK ; Myung Gyu CHOI ; Sutep GONLACHANVIT ; Andrew S B CHUA ; Kuck Meng CHONG ; Kewin T H SIAH ; Ching Liang LU ; Lishou XIONG ; William E WHITEHEAD
Journal of Neurogastroenterology and Motility 2015;21(1):83-92
BAome III criteria. METHODS: After EAR3Q was developed by Asian experts by cCKGROUND/AIMS: The development-processes by regional socio-cultural adaptation of an Enhanced Asian Rome III questionnaire (EAR3Q), a cultural adaptation of the Rome III diagnostic questionnaire (R3DQ), and its translation-validation in Asian languages are presented. As English is not the first language for most Asians, translation-validation of EAR3Q is essential. Hence, we aimed to culturally adapt the R3DQ to develop EAR3Q and linguistically validate it to show that the EAR3Q is able to allocate diagnosis according to Ronsensus, it was translated into Chinese, Hindi-Telugu, Indonesian, Korean, and Thai, following Rome Foundation guidelines; these were then validated on native subjects (healthy [n = 60], and patients with irritable bowel syndrome [n = 59], functional dyspepsia [n = 53] and functional constipation [n = 61]) diagnosed by clinicians using Rome III criteria, negative alarm features and investigations. RESULTS: Experts noted words for constipation, bloating, fullness and heartburn, posed difficulty. The English back-translated questionnaires demonstrated concordance with the original EAR3Q. Sensitivity and specificity of the questionnaires were high enough to diagnose respective functional gastrointestinal disorders (gold standard: clinical diagnoses) in most except Korean and Indonesian languages. Questionnaires often uncovered overlapping functional gastrointestinal disorders. Test-retest agreement (kappa) values of the translated questionnaires were high (0.700-1.000) except in Korean (0.300-0.500) and Indonesian (0.100-0.400) languages at the initial and 2-week follow-up visit. CONCLUSIONS: Though Chinese, Hindi and Telugu translations were performed well, Korean and Indonesian versions were not. Questionnaires often uncovered overlapping FGIDs, which were quite common.
Asia
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Asian Continental Ancestry Group*
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Constipation
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Diagnosis*
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Dyspepsia
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Follow-Up Studies
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Gastrointestinal Diseases
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Heartburn
;
Humans
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Irritable Bowel Syndrome
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Surveys and Questionnaires*
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Sensitivity and Specificity
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Translations