Since its initial description in 1930, the preexcitation or Wolff-Parkinson-White(W-P-W) syndrome is characterized by a special electrocardiographic pattern and various paroxysmal tachyarrhythmia, which was found to have reciprocating tachycardia frequently. The W-P-W syndrome develops when some part of a ventricle is activated earlier than normal conduction pathway, and described as one type of ventricular preexcitation syndromes by Durrer (1974). The diagnostic criteria of the W-P-W syndrome are 1) initial slurring (delta wave) of the QRS complex, 2) short P-R interval, 3) widened QRS complex and 4) secondary T wave change. The initial slurring of the QRS complex (delta wave) which is the most important finding of preexcitation syndrome results from a premature activation of a portion of the ventricle through an accessary pathway which bypasses the A-V node and bundle. These accessary conduction fiber includes Kent's bundle, Jame's fibers, Mahaim's fibers and its combination. Recent developments in the field of electrophysiology and surgical therapy became to support the concept of anomalous pathways and the possible determination of the re-entry circuit of paroxysmal tachycardia. Total 12 cases including 9 cases of classical W-P-W syndromes and 3 cases of L-G-L syndromes were followed with special interest of pre-excitation phenomenon and paroxysmal tachyarrhythmia at the National medical Center during the period of Jan. 1975 to Feb. 1979 and found to have paroxysmal tachyarrhythmia in 8 cases out of 12 cases. His bundle electrogram (HBE) and right atrial pacing were recoded in 2 cases of W-P-W type B to support the existance of an anomalous pathway. Treatment was instituted in accordance with recent advanced knowledge for the paroxysmal tachyarrhymia and pre-excitation and references were reviewed.
Atrioventricular Node ; Electrocardiography ; Electrophysiologic Techniques, Cardiac ; Electrophysiology ; Pre-Excitation Syndromes ; Tachycardia ; Tachycardia, Paroxysmal ; Tachycardia, Reciprocating ; Wolff-Parkinson-White Syndrome*

To establish in vivo antiviral evaluation system by using murine herpesvirus intracerebral infection model, 5-6 female BALB/c mice per group aged 5 weeks were inoculated i.c. into cerebrum with different inocular HSV-1 F. Signs of clinical disease noted everyday for one month. Observed were body weight decrease, neurological signs and death caused by encephalitis. Mice discontinued body weight decrease were recovered from the disease, and keratitis was often observed during recovery. The groups inoculated with higher than 1,000 PFU showed 100% mortaltiy and LD50 was <100 PFU/mouse. To study the effect of virus inoculum sizes on antiviral effect of acyclovir (ACV), mice inoculated with different inocula were administered i.p. with different doses of ACV immediately after infection, and twice a day for 5 days. The higher inculum size, the less protective. ED50 of ACV was >25, >25, 18.4 and 8.0mg/kg b.i.d. in the group infected with 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. LD50 of ACV was 62.5 mg/kg b.i.d. Therapeutic index of ACV was <2.5, <2.5, 3.0 and 7.0 in the groups with inocula 1,000,000, 100,000, 10,000 and 1,000 PFU/mouse, respectively. Inoculum size 1,000 PFU/mouse showing 100% mortaltiy and 5-6 days mean time to death, 5 days drug administration and 14 days observation will be future exeperimental conditions.
Acyclovir* ; Animals ; Body Weight ; Cerebrum ; Encephalitis ; Female ; Herpesvirus 1, Human ; Humans ; Keratitis ; Lethal Dose 50 ; Mice*

No abstract available.
Antiviral Agents* ; Herpes Simplex* ; Herpesvirus 1, Human* ; Simplexvirus*

No abstract available.
Nucleic Acids*

Primary aldosteronism is a disease that the stimulus for the excessive aldosterone production residues within the adrenal gland. It was first described by conn in 1955. And many cases were reported by physicians at present in the world. But it is relatively rare in Korea, probably due to lack of attention and medical facilities. Only about 13 cases have been reported at present. The clinical, biochemical feature in l case of primary aldosteronism caused by adrenal hyperplasia that was diagnosed at Yeungnam University Hospital was observed and the following result were obtained. 1. Clinical feature: The present case was 27-year-old woman who was admitted due to general weakness and easy fatigability. The above mentioned chief complaints occurred 8 months prior to admission when she delivered of second baby by cesarean section. Symptoms such as above chief complaints, intermittent muscle paralysis and cramping were noticed. Trousseau's sign was also present. The average blood pressure ranged from 170/90 to 200/120 2. Biochemical abnormalities: Severe hypokalemia lower than 2.5 mEq/L was presented and 24 hours urine potassium showed markedly increased urinary loss (228 mEq/day). Plasma rennin activity was decreased under normal range with furosemide administration. (Basal renin; 0.01 ng/ml/hr, stimulated rennin 0.12 ng/ml/hr). Saline suppression test revealed markedly elevated levels of aldosterone higher than normal range (Basal aldosterone; 320.68 pg/ml stimulated aldosterone; 451.86 pg/ml). And posture test showed decreased plasma rennin activity and increased plasma aldosterone level. 3. Adrenal CT scan revealed no abnormal findings. 4. Treatment and course: Spironolactione was given at OPD with regular follow-up. Her blood pressure ranged from 150/90 to 160/100 and symptoms were improved. The effect of treatment was satisfactory and further follow up would be performed.
Adrenal Glands ; Adult ; Aldosterone ; Blood Pressure ; Cesarean Section ; Chymosin ; Female ; Follow-Up Studies ; Furosemide ; Humans ; Hyperaldosteronism* ; Hyperplasia* ; Hypokalemia ; Korea ; Muscle Cramp ; Paralysis ; Plasma ; Posture ; Potassium ; Pregnancy ; Reference Values ; Renin ; Tomography, X-Ray Computed

We evaluated the therapeutic effect of potassium iodide in fourteen patients with erythema nodosum. The results were as follows: 1) All patients were given a saturated solution of potassium iodide, 600 to 900 mg orall y a day for 3 days to 5 weeks. 2) Three patients were observed initial days, two patients within 9 days. 3) There were no correlations between therapeutic effect of potassium iodide. 4) Specific side effects were not found during the treatment with potassium iodide.
Erythema Nodosum* ; Erythema* ; Humans ; Potassium Iodide* ; Potassium*

In 20 patients with psoriasis, 27 early psoriatic lesions of 1-2mm size (16 papules with scale and 11 maculopapules without scale) and 15 clinically uninvolved skin at distance of 2-4em from the nearest psoriatic lesion were histologically examined in an attempt to obtain information on the mechanism which initiates the development of the skin changes. (countinued..)
Humans ; Psoriasis ; Skin

STUDY DESIGN: We analysed the pre-vertebral soft tissue measurements in cervical spine trauma patients. OBJECTIVES: We tried to determine the sensitivity and specificity of soft tissue measurements in patients with radiographically proven cervical spine fracture and to investigate the diagnostic value of the measurements. SUMMARY OF LITERATURE REVIEW: Widening of the pre-vertebral soft tissue is a well recognized sign in injury of the cervical spine. But the diagnostic value of this widening is still controversial. MATERIALS AND METHODS: Width of the prevertebral soft tissue on lateral cervical spine radiographs was measured for 52 patients with a history of cervical spine trauma and for 53 patients complaining of cervical discomfort without a history of trauma. As a normal Korean adult standard, 7mm at C2 level, 8mm at C3 level, and 16mm at C6 level were considered the upper limit. Width of the prevertebral soft tissue was measured as a distance between antero-inferior margin of the body of cervical spine and the most posterior border of the larynx and trachea. RESULTS: A C2 prevertebral soft tissue measurement of more than 7mm had a sensitivity of 35% and a specificity of 86%. A C3 measurement of more than 8mm had a sensitivity of 35% and a specificity of 72%. A C6 measurement of more than 16mm had a sensitivity of 30% and a specificity of 80%. CONCLUSIONS: The prevertebral soft tissue measurement seems to be of limited diagnostic value. Further study may be required to determine more acceptable limits of normal cervical spine measurement in Korean population.
Adult ; Humans ; Larynx ; Sensitivity and Specificity ; Spine* ; Trachea

Osteosarcoma is a malignant tumor arising from the undifferentiated fibrous tissue of bone and one of the mostcommon pirmary malignant tumors of bone. The diagnosis of osteosarcoma is based one can be diagnosed with areasonable degree of confidence from the conbination of the lesion site, age and radiological findings. This is aclinical and radiological observation of 40 cases of osteosarcoma which were experienced at Chonnam NationalUniversity Hospital, Chosum University Hospital and Kwangju Christian Hospital from 1978 to 1981. The results wereas follows; 1. The peak incidence was in the age group from 10 to 19 years in 21 cases (52.5%). 2. In sexdistribution, male group showed slightly higer incidence than in female group with the ratio of 1.35;1. 3. Themost commonly affected site was proximal tibia(35%). The lesion was found around the knee in 65% of the studiedcases. 4. Increment of the level of serum alkaline phosphase was observed in 25 cases (62.5%), and the averagevalue of serum alkaline phosphature in these cases was 5.6 Bessay Lowry units. 5. Radiographically, osteoblastictype was 14 cases (35%), and soft tissue mass shadow with calcification was observed in 34 cases (85%). 6.Cortical destruction was observed in 30 cases (75%), and soft tissue mass shadow with calcification was observedin 34 cases (85%). 7. Solid periosteal reaction, sunburst periosteal reaction and Codman's triangle were observedin 35%, 57.5% and 22.5% respectively. 8. At the first visit, lung meatastasis was found in 5 cases (12.5%) andinguinal lymphnode metastasis in 2 cases (5%)
Diagnosis ; Female ; Gwangju ; Humans ; Incidence ; Jeollanam-do ; Knee ; Lung ; Male ; Neoplasm Metastasis ; Osteosarcoma ; Sulindac

BACKGROUND: Acute normovolemic hemodilution (ANH) and deliberate hypotension (DH) are methods used for reducing homologous transfusions in cases of massive intraoperative bleeding. Using the technique of combining ANH and DH, we can save more homologous blood than a single use of ANH or DH, but the risk of tissue hypoxia may increase. METHODS: Fourteen male dogs were used for this study and divided into two groups. After performing ANH by 25 ml/kg, mean arterial pressures were reduced to 60 mmHg by sodium nitroprusside (S group) or esmolol (E group). The critical oxygen delivery and the hemoglobin concentration at the critical oxygen delivery were determined by measurements of hemodynamic change, systemic oxygen delivery and systemic oxygen consumption during subsequent hemodilution. RESULTS: After performing ANH by 25 ml/kg, the cardiac output was significantly increased, and systemic vascular resistance and hemoglobin concentration were significantly decreased compared with control values. The critical oxygen deliveries were 179.6 ml/min in the S group and 169.1 ml/min in the E group. There was a difference in mean systemic oxygen consumption between the S group (123.4 +/- 16.7 ml/min) and E group (112.9 +/- 15.4 ml/min) above the critical oxygen delivery point (mean +/- SD). The hemoglobin concentrations at the critical oxygen delivery were 2.6 +/- 0.7 g/dl in S group and 4.0 +/- 1.3 g/dl in E group (mean +/- SD). CONCLSIONS: The critical oxygen delivery during hemodilution under DH by sodium nitroprusside was 179.6 ml/min and by esmolol was 169.1 ml/min. However, esmolol was higher in hemoglobin concentrations at the critical oxygen delivery than sodium nitroprusside. These results suggest thathemodilution under DH by esmolol rather than sodium nitroprusside requires more careful monitoring of systemic oxygen delivery for prevention of tissue hypoxia.
Animals ; Anoxia ; Arterial Pressure ; Cardiac Output ; Dogs* ; Hemodilution* ; Hemodynamics ; Hemorrhage ; Humans ; Hypotension* ; Male ; Nitroprusside* ; Oxygen Consumption ; Oxygen* ; Sodium* ; Vascular Resistance