Objective To observe the clinical effect of combined treatment of single tooth loss and implant denture.Methods The clinical data of 80 patients with single tooth loss were analyzed retrospectively.According to the different surgical methods,they were randomly divided into control group and observation group,40 cases in each group.The control group was treated with implant denture,the observation group was treated with orthodontic treat-ment.The clinical efficacy of the two groups was observed.Results The total effective rate of the observation group was 97.50%,which was significantly higher than 62.50% of the control group(χ2 =15.31,P <0.05).The satisfac-tion scores of the observation group were higher than those of the control group,the differences were statistically signif-icant(t =12.21,17.78,15.98,11.85,9.35,all P <0.05).Conclusion The clinical effect of combined treatment of orthodontic and dental implants for patients with single tooth loss is remarkable,and can achieve good results,and improve the treatment satisfaction,it is worth promoting.

Objective To analyze the clinical effect of membrane guided bone regeneration technique combined with 3 I implant system in anterior dental implant.Methods 50 patients with anterior teeth missing were selected as the experimental group,they received membrane guided bone regeneration technique combined with 3 I implant system of dental implant.50 cases alone with 3 I implant system of dental implant were selected as the control group.The clinical data were retrospectively analyzed.The effects of the two groups were compared.Results Statistical results showed that the satisfaction of appearance and function had significant difference between the two groups(χ2 =6.73,P<0.05).The operation area of plaque index (PLI) (t=3.16,P<0.05),gingival sulcus bleeding index (MBI) (t=6.32,P<0.05),probing depth (PD) (t=2.63,P<0.05) had significant differences between the two groups.The thickness of the buccal tongue of the bone graft,and other indicators of the top of the implant to the top of the alveolar ridge showed significant differences between the two groups (t=17.65,P<0.05,t=8.48,P<0.05). Conclusion Using membrane guided bone regeneration technique and 3 I implant system combined application can improve dental implant in the anterior and the success rate of patients on the appearance and function of satisfaction after dental implant in the anterior,and to broaden the bone defect of anterior tooth planting the indication effect,it is worthy of clinical promotion.

Objective To compare the clinical efficacy of small titanium plate rigid internal fixation and intermaxillary fixation in the treatment of simple mandibular fracture,and to explore the best treatment method for the reduction of fractures of the mandible.Methods 252 cases with simple fractures of the mandible were randomly divided into the two groups.126 cases of group A were treated by rigid internal fixation,126 cases of group B were treated by intermaxillary fixation.The patients were followed up for 6 months after operation.The complications,occlusion and mouth opening were compared between the two groups.And then,the data were analyzed.Results 120 cases of group A occlusal relation recovered to normal,the appearance and function were recovered well.The average mouth opening was 3.90cm.4 cases got postoperative infection,1 case titanium plate was broken.118 patients of B group occlusal relation recovered to normal,the appearance and function were restored,no case of infection and clamp plate broken.10 cases happened bad oral health condition,gingiva swell and teeth loosen.8 cases complicated with bad occlusion.There were no statistical differences between A and B group about occlusion and(x2=0.30,0.86,all P ＞ 0.05).Conclusion Two treatment methods are effective in the treatment of simple mandibular fracture,rigid skillfully master indication to get best efficacy.

0.05).All cases showed normal bone formation. Conclusion:There is no significant influence on tibial growth if cancellous bone harvesting is controlled strictly in two third of total amount from tibial proximal metaphyses.

Objective To study the inhibitory effects of modification c-myc antisense oligodeoxynucleotide (ASODN) on the growth of renal carcinoma cell line (GRC-1) and cell cycle. Methods We transfected c-myc antisense oligodeoxynucleeride in renal carcinoma cell line to investigate the effect of c-myc ASODN on it. Results ① By MTT assay,we found that the c-myc ASODN significantly inhibited the growth of carcinoma cell, compared with sense and mismatch ODN. The growth-inhibition rate of 12 ?mol?L -1 c-myc ASODN group of renal carcinoma cell was 47% at 48 hour, and the inhibitory effect increased with the increase of ASODN dosage and changed with ASODN time. ② The measurements by flow cytometry proved that ASODN mainly blocked the G 1 to S of the cycling of renal carcinoma cell. Conclusion c-myc ASODN can inhibit the growth of renal carcinoma cells with sequence specificity and cycling specificity.

Objective To explore the effect of the straight line and the auxiliary incision of lip skin on repairing unilateral incomplete cleft lip.Methods 120 cases of unilateral incomplete cleft lip repaired with the straight line method and reconstruction of the orbicularis oris muscle with the auxiliary incision of lip skin.Results 2 cases of cleft relapse by tumble.The wound of 115 children were healed one stage.3 children were healed two stage.All children didn't present vermilion deficiency.The upper lip presented natural labial groove between affected and unaffected side.Both sides of nostrils were symmetry and scars were not ovbious.Conclusion This new method was simple and effective in repairing unilateral incomplete cleft lip.

Objective To compare the clinical effects of hip replacement and internal lixation treatment for aged patients with fracture of femoral neck.Methods One hundred and twelve cases patients with fracture of femoral neck were choosed and divided into the control group (n =56) and observation group (n =56) according to the will of patients and family.The control group was treated by incision fixation while the observation group was given hip replacement therapy.All patients were followed up for 6 months after the operation time.Intraoperative blood loss,hospital stay,bed time,postoperative complications and Harris joint scores of the two groups were compared.Results The operation time and intraoperative blood loss of the observation group were significantly higher than those of the control group((98.6±23.8) min vs.(54.2± 16.4) min,(324.6 ±43.8) ml vs.(158.6±26.8) ml;t=4.468,5.624;P＜0.05);The bed time was much shorter than that of the control group((16.6±2.8) d vs.(68.6±5.8) d;t=8.248,P＜0.05).The case of pressure sores,lung infection and mode again of the observation group were significantly less than those of the control group(P＜0.05),while the Harris joint scores were significantly higher than the control group (89.7％ vs 58.9％,x2 =14.423,P ＜0.05).Conclusion Hip replacement can improve the joint function and enhance the quality of life for patients of fracture of femoral neck.

Objective To explore the effect of clinical pathway in surgical treatment for patients with mandibular fracture.Methods 80 patients with mandibular fracture were randomly divided into the conventional therapy group(the control group) (n =40） and the clinical pathway therapy group (CP group) (n =40).The hospitalization time,medical expenses,satisfaction for the treatment,health awareness,and incidence of complications were compared between two groups.Results The results of hospitalization time,medical expenses,satisfaction for the treatment,and health awareness of the CP group were (11.86 ± 3.05) d,(9 115.43 ± 1 689.84) yuan,(91.19 ± 1.02) ％,(95.18 ±4.11)points,respectively,which were significantly better than those of the control group [(17.53 ± 2.98)d,(12 066.75 ±2 513.22)yuan,(89.39 ±1.35)％,(82.83 ± 6.56) points] (t =8.41,6.16,6.73,10.01,all P ＜0.05).The complication rate of the two groups was 2.5％,7.5％,respectively,which had no significant differences (χ2 =0.26,P ＞ 0.05).Concltsion The clinical pathway for mandibular fracture surgery is worthy of promotion.

To investigate the effect of naringenin on ovariectomy-induced postmenopausal osteoporosis comprehensively and systemically, thirty-two virgin Sprague-Dawley rats about 3-month-old were used and randomly divided into 4 groups: sham control group (Sham), OVX control group (OVX), naringenin treatment group and 17β-estradiol (E2) treatment group. After 12 weeks treatment with different drugs, 24 h urine were collected, organs were weighed and the organ indies were computed. Uterine pathological changes were observed by making paraffin section. Biochemical parameters and bone turnover markers: serum osteocalcin (BGP) and urine deoxypyridinoline (DPD) were analyzed with automatic biochemical analyzer or ELISA assay. Bone mineral density (BMD) and bone mineral content (BMC) were analyzed by DEXA, bone biomechanical properties was measured by three point bending test and the trabecular bone microarchitecture was evaluated by Micro CT. From the results, we can see that: the gaining of weight and the increasing of bone turnover markers such as serum BGP and urinary DPD could be inhibited by naringenin. The treatment could also enhance the bone strength and prevent the deterioration of trabecular microarchitecture, increase the bone volume, trabecular number and thickness, and decrease the trabecular space. The effects mentioned above were not accompanied with stimulating effects on uterus. Long-term using of naringenin had no obvious influence on other organs and the liver and kidney functions. The study suggests that naringenin had obvious antiosteoporotic effect on ovariectomized rats and it had the potential value for the treatment of postmenopausal osteoporosis.

Objective To explore the effects of AP on pulmonary fibrosis. Methods Alveolar macrophages (AM) were treated by AP for 24 hours. Pulmonary fibroblasts (FB) were cultured with the supernatant of AM medium. The protein of transforming growth factor beta 1 (TGF-?1) of AM, the proliferative activity and hydroxyproline (Hyp) content of FB were examined. Rats were treated with AP by intratracheal instillation and sacrificed at 3 days. The TGF-?1 mRNA content in the lung was examined. Results The positive staining macrophages in low and high AP groups and the quantity of TGF-?1 in high AP group were obviously higher than those in the control group (P