This study was designed to evaluate the therapeutic effect of H2 and H2 antihistaminics on dermographism. Twenty four patients with dermographism were allocated on a random to one of the following 3 treatment regimens. A) chlorphenirarnine and cimetidine (H1+H1) B) chlorpheniramine alone (H>) C) cimetidine alone (H) The patients cutaneous response to the dermographometer was assessed at weekly intervals for four weeks. The results were as follows: 1. The combinded treatment with chlorpheniramine and cimetidine was significantly more effective in inhibiting wheal and flare than the cimetidine alone (wheal p<0.01, flare p<0.02). 2. Following comparisions were not statistically significant: chlorpheniramine+ cimetidine vs chlorpheniramine (p>0. 05), chlorpbeniramine alone vs cimetidine alone(p>0.05). 3. Main side effects were drowsiness (3 cases) and mild gastric disturbance (2 cases) on hlorpheniramine alone.
Chlorpheniramine ; Cimetidine ; Histamine H2 Antagonists* ; Humans ; Sleep Stages

We examined a male infant with transient increase in alkaline phosphatase(ALP) activity. The 25-month-old infant was admitted to a local hospital because of pneumonia of unknown etiology. Initial laboratory investigation revealed a serum ALP of 11,260U/L, which was comparable to that of bone isoenzyme on the electrophoresis pattern, There was no evidence of hepatitis, skeletal or intestinal diseases. The hyperphosphatasemia disappeared 3 months later. We report a case of transient hyperphosphatasemia diagnosed inci- dentally in the course of management of pneumonia. (J Korean Pediatr Soc 2000;43:856-860)
Alkaline Phosphatase ; Child, Preschool ; Electrophoresis ; Hepatitis ; Humans ; Infant ; Intestinal Diseases ; Male ; Pneumonia

No abstract available.
Hyperplasia*

A study was made on 657 cases of skin tumors, which were obtained mainly as surgical pathology specimens during the period of 12 years and 4 months from January, 1960 to April, 1972, at Departments of Dermatology and Clinical Pethology, Catholic Medical Center in Seoul, and the results were as follow; 1) Of the 657 cases of skin tumors, 470 cases (71. 5%) were benign tumors, 26 casea (4.0%) premalignant lesions and 161 cases (24. 5%) malignant tumors. 2) The ratio of male vs. female was 1: 1 for benign tumor, 1: 1.9 for premalignant lesion and 1. 9: 1 for malignant tumor. 3) Among the benign tumors were 144 cases of cysticercosis, 68 cases of epidermal inclusion cyst, 46 cases of hemangioma and 45 cases of lipoma. 4) Arnong the premalignant lesions were 13 cases of leukoplakia, 5 cases of Nevus sebaceous (Jadassohn) and 4 cases of Bowen's disease. 5) The average age of malignant tumor was 53. 2 years for squamous cell carcinoma, 57. 2 years for basal cell carcinoma, and 35. 6 years for malignant melanoma. 6) The sites of predilection of the squamous cell carcinomas were penis (30. 6%), face (27. 4%) and upper and lower extremities (12.9%). The site of predilection of the basal cell carcinomas was face (88. 5%)., 7) The ratio of squamous cell carcinoma vs. basal cell carcinoma was 2. 4: 1. 8) Among the metastatic cancers of the skin the more frequent primary sites were stomach (3 cases), lung (2 cases) and liver (2 cases).
Bowen's Disease ; Carcinoma, Basal Cell ; Carcinoma, Squamous Cell ; Cysticercosis ; Dermatology ; Female ; Hemangioma ; Humans ; Leukoplakia ; Lipoma ; Liver ; Lower Extremity ; Lung ; Male ; Melanoma ; Nevus ; Pathology, Surgical ; Penis ; Seoul ; Skin* ; Stomach

No abstract available.
Aorta*

BACKGROUND: Systemic lupus erythematosus(SLE) is a clinical syndrome of unknown causes characterized by inflammat.ion and multisystem involvement. Since Hargravas describe the LE cell in 1948, a profound change has occured in the concept of SLE. Many studies of the large series have been reported in the West, but few collective studies have been reported in Korea. OBJECTIVE: The goal of this study was to elucidate the clinical and laboratory characteristics of SLE in Korean people. METHODS: We carried out retrospective study of 64 patients, who were diagnosed as SLE on the base of the 1982 revised bacteria for the SLE by American Collepe of Rheumatology(formerly, American Rheumatism Association), at Korea University Hospital from 1982 to 1991. The results were compared with those of previous studies in Korea and western countries. RESULTS: 1. In 64 patients with SLE, female patients outnumbered male by 6.1 to 1 and the mean age of onset was 28.6 years. 2. The initial manifestations were arthritis or arthralgia, 25%; fatigue, malaise, weight, loss, 21.8%; facial rash or blush, 12.5%, fever, 12.5%. 3. The major clinical manifastations were hematologic(90.6 %), muccutaneous(89%), musculoskeleta (79.7%), and renal(73.4%) involvemant. 4. The ANA test were positive in 83.9% of the patients, and homoenous pattern was most common. There was no significant difference of organ involvement according to the nuclear patterns of ANA, but cardiopulmonary, renal involvement, hypocomplement,emia and positive anti-ds DNA were less frequent in ANA neghative group. 5. In 73.7% of the patients, the titers of anti-ds DNA antibody was elevated. The amount of anti-ds DNA Ab in serum did not always correlate with disease activity. 6. Photosensitivity, arthritis or arthralgia and CNS manifestatioris were less common, but hematologic findings, including anenia and leukopenia were more common in Korean than western reports. CONCLUSION: Patients with SLE are heterogenous in the natural h story of their disease, which is not an uncommon disease in Korea. Continued efforts to clarify the immunopathologic basis for SLE should eventually lead to more effective treatment.
Age of Onset ; Arthralgia ; Arthritis ; Bacteria ; DNA ; Exanthema ; Fatigue ; Female ; Fever ; Humans ; Korea ; Leukopenia ; Lupus Erythematosus, Systemic* ; Male ; Neutrophils ; Retrospective Studies ; Rheumatic Diseases

Having had an occasion to observe a case of extramammary Paget's disease affecting 69 year-old man, who has been suffered from well demarcated erythematous eczemstoid pruritic patch incolving penis, serotum, and suprapubic area since 3 years previously, we report.
Aged ; Humans ; Male ; Paget Disease, Extramammary ; Penis

No abstract available.
Tracheoesophageal Fistula*

We have observed clinically 57 cases of diphtheria, admitted to Dept. of Pediatrics and E. N. T. of College of Medicine, Busan National University during a period of past 4 years from Jan. 1973 to Dec. 1976. The following results were obtained from this observation: 1. The yearly prevalence rate seemed not to be reduced throughout 4 years. 2. The seasonal incidence was highest from Oct. to next Feb when 77.5% of cases was de-veloped. Most of cases (82.5%) was below the age 8 years with the sex ratio of male to female, 1.5:1. 3. About one half of cases gad been resided in the rural area. 4. Concerning the degree of the immunization status of diphtheria, 48.3% of cases was never taken, 17.5% unknown, 33.4% inadequate, and 5.3% was adequate. 5. The sites of occurence of dephtheria were pharynx (33.3%) larynx (47.4%) and both (19.3%) 6. 77.2% of cases was found diphtheria organism, which was detected on smear (63.2%) and culture (52.6%) individually. 7. The chief clinical symptoms and signs on admission were dyspnea (77.2%) pseudomemb-rane (77.2%) prostration (75.4%) fever (72.0%) hoarseness (54.4%) cough (50.9%) and the like in order of frequency. 8. Anemia was found in 77.2% leukocytosis in 84.2% of cases. 9. 54.5% of cases had complications, of which myocarditis (22.4%) pneumonia (21.0%)bull neck (14.0%) nephritis (12.2%) and nerve palsy (10.5%) were developed. 10. The onest of myocarditis was the 3th-8th day of depheheria and the most common abnormal ECG finding was the changes of S-T segment and T wave. 11. The morality rate was 12.3% of the total cases (45.5% of mixed type the and 7.4% of laryngeal type were expired). The causes of death were myocarditis (its mortality rate, 46. 1%) and paralysis of diapgragm.
Anemia ; Busan ; Cause of Death ; Cough ; Diphtheria* ; Dyspnea ; Electrocardiography ; Female ; Fever ; Hoarseness ; Humans ; Immunization ; Incidence ; Larynx ; Leukocytosis ; Male ; Morals ; Mortality ; Myocarditis ; Neck ; Nephritis ; Paralysis ; Pediatrics ; Pharynx ; Pneumonia ; Prevalence ; Seasons ; Sex Ratio

To investigate differentiation and growth process of keratinocytes in organotypic cultured skin, we carried out immunohistochemical studies for cytokeratin (CK) 10, 14, 16, 17 and involucrin in the cultured skin. In normal skin CK14 and CK10 were detected in the basal and all suprabasal layer, respectively, whereas in artificial skin CK14 was detected up to the middle of spinous layer but CK10 expressed from the middle of spinous layer. The detection of involucrin in normal skin was from the upper spinous layer but found from lower spinous layer in the artificial skin. Both CK16 and CK17 did not expressed in in vivo skin but expressed weakly in the spinous layer of artificial skin. It is therefore concluded that the characteristics of basal cell were maintained in the several, lower layers of the sartificial skin. The growth and differentiation steps of the skin were similar to those of in vivo although differences were seen in the expression level.
Cells, Cultured* ; Epidermis* ; Immunohistochemistry ; Keratinocytes ; Keratins* ; Skin ; Skin, Artificial*