A clinica1 study was carried ou on the 98 cases of purpura who were admitted to the Han Gang Sung Shim Hospital during the period of 3 years from Sept., 1975 to Aug., 1978. The results were as follows: 1. The most common cause of purpura was allergic purpura (35.7%). 2. The highest incidence was under 10 years of age group(63.3%), and males were more frequently affected tban fomal with the ratio of 1.3: l. 3. The saonal incidence of purpura was high during the period of 5 months fror Jan. to Klay. Especially in the allergic purpura high incidence was seen in April, May and October. 4. The preclilection site of purpura was on the lower extremities (87.5%) Especially in allergic purpura, the purpura lesions were occured on the lower extremities in all cases. 5, Platelet count in allergic purpura was normal, and that of L.T.P., leukemia, menigococcemia, aplastic anemia and sepsis was decreased in mostly all cases. 6. Bleeding; time was normal in allergic purpura, hut prolonged in ahout 50% of otber diseases. Coagulation time was normal in all cases. 7. Occuit blood was positive in 40% of all cases. 8. Renal rnan!festations occured in 37 cases(37.8%). The most common among them was proteinuria(89.2%)
Anemia, Aplastic ; Hemorrhage ; Humans ; Incidence ; Leukemia ; Lower Extremity ; Male ; Platelet Count ; Purpura* ; Purpura, Schoenlein-Henoch ; Sepsis

BACKGROUND: The generation of the invasiveness in transfromed cells represents an essential step of tumor progression. The primary cause of the scattering of the cells in invasive carcinoma is a loss of the integrity of the intercellular adherens junction often involving loss of a functional cell-cell adhesion molecule E-cadherin. Therefore, the perturbation of E-cadherin function causes diaggregation of tumor cells and may promote the invasion and metastases. OBJECTIVE: The reduction in E-cadherin activity seems to correlate with the infiltrative ability of tumor cells. The purpose of this study was to compare the E-cadherin expression among different cell lines which were normal to undifferentiated and to check the virtual relationaship between E-cadherin and invasiveness. METHODS: We used 5 cell lines, HaCaT, A431, C3, SiHa and HeLa cell. To check the expression patterns and amounts of E-cadherin in each cell line, immunofluorescence staining, Western blot anlysis and Northern blot analysis were done. An in vitro invasion assay using the collagen gel and MRC-5 fibroblast under the influence of HECD-1 antibody which block the E-cadherin function was done to measure the invasiveness of tumor cells. Collagenase activity in culture supernatants of each cell were analyzed by zymography. RESULTS: Immunofluorescence staining revealed a homogenously well preserved pattern in HaCat, A431, C3 cells. SiHa cells showed patch distribution but HeLa cells did not express the E-cadherin. Western blot analysis and Northern blot results largely corresponded with the immunofluorescence results. The in vitro invasion assay revealed invasion into the collagen matrix of the HeLa cells. When HECD-1 antibody was added to the medium, other cells showed partially disrupted stratification. The collagenolytic activity at 72 kDa sixe was detected in the HeLa cell line only. CONCLUSION: There is an inverse relationship between E-cadherin expression and tumor invasion. Therefore, through their regulation of cell adhesion and motility, cadherin plays a crucial role in the suppression of tumor invasion and metastasis.
Adherens Junctions ; Blotting, Northern ; Blotting, Western ; Cadherins* ; Cell Adhesion ; Cell Line* ; Collagen ; Collagenases ; Fibroblasts ; Fluorescent Antibody Technique ; HeLa Cells ; Humans ; In Vitro Techniques ; Neoplasm Metastasis

This study was designed to evaluate the therapeutic effect of H2 and H2 antihistaminics on dermographism. Twenty four patients with dermographism were allocated on a random to one of the following 3 treatment regimens. A) chlorphenirarnine and cimetidine (H1+H1) B) chlorpheniramine alone (H>) C) cimetidine alone (H) The patients cutaneous response to the dermographometer was assessed at weekly intervals for four weeks. The results were as follows: 1. The combinded treatment with chlorpheniramine and cimetidine was significantly more effective in inhibiting wheal and flare than the cimetidine alone (wheal p<0.01, flare p<0.02). 2. Following comparisions were not statistically significant: chlorpheniramine+ cimetidine vs chlorpheniramine (p>0. 05), chlorpbeniramine alone vs cimetidine alone(p>0.05). 3. Main side effects were drowsiness (3 cases) and mild gastric disturbance (2 cases) on hlorpheniramine alone.
Chlorpheniramine ; Cimetidine ; Histamine H2 Antagonists* ; Humans ; Sleep Stages

This paper is studied for statistical anaIysis of 1181 cascs of positive V.D.R.L test among 24414 cases who were visited for annual Physical examination and in or outpatients in the Han Gang Sung Shim Hospital during 5 years and 7 months from January 1972 to July 1977. Clinical survey was carried out with 182 syphilitic patients in the Department of Dermatology, Han Gang Sung Shim Hospital during 19 months from January l976 to July 1977. The results were as follows; 1. Positive rate for V.D.R.L test was 4.8%, and there were statistically significant differences in annual incidence(P<0.01). Biologic false positive rate for V.D.R.L test was 26. 7%, and there were statistically aignificant differences in annual incidence(P<0.01). 2. Departmental analysis such as Dermatology, Urology, Physical Examination and others including Obstetrics and Gynecology, Internal Medicine, Pediatrics etc. were carried out, the results showed that there were statistically significant departmental differences in V.D.R.L positive rate, but no in biologic false positive rate. 3. Biologic false positive rate was high inversely proportional to dilution titer, and that was a statistically significant difference(P<0.01). 4. 182 had syphilis, of whom 106(58. 2%) were latent syphilis and 74(40. 7%) were primary and secondary syphilis. 5. 119(65. 4%) among 182 syphilitic patients were male, most of patients(87.8%) occured in age from 21 to 40 years in the both sex. But there no statistically significant differences in age distribution between males and females. 6. The most predilection site of chancre was coronary sulcus(54.5%). 7. The lesions of secondary syphilis were composed of 18 cases(25%) of condyloma latum, 17 cases(23. 6%) of roseolar syphilid, 17 cases of papulo-squamous syphilid, 13 cases of alopecia syphilitica, 1 case of pustular syphilid, and 6 cases of others. 8. Married patients were nearly two times than single. In women, married. patients were much more(80. 3%) than single, and there were statistically significatnt differences(P<0.01). 9. There were no significant differences in S.T.S positive rate of spouse between infectious and latent syphilis. 10. Occupation distribution of male sexual partners were composed of 35 cases(29. 4%) of waitress, 28 cases(23. 5%) of call-girl, 20 cases(16. 8%) of office-girl, 17 cases of housewife, 12 cases of out of work, 7 cases of student. 1I. For patients with primary, secondary, and latent syphilis, treatment consiste of benzathine penicillin 2. 4 million units intramuscularly on the first visit and repeated three penicillin preparations at 7 days intervals in most of patients.
Age Distribution ; Alopecia ; Chancre ; Dermatology ; Female ; Gynecology ; Humans ; Internal Medicine ; Male ; Obstetrics ; Occupations ; Outpatients ; Pediatrics ; Penicillin G Benzathine ; Penicillins ; Physical Examination ; Serologic Tests* ; Sexual Partners ; Spouses ; Syphilis* ; Syphilis, Cutaneous ; Syphilis, Latent ; Urology

Pretibial myxedema, which consists of localized cutaneous accumulations of acid mucopolyeaccharides, occurs in a small percentage of patients with diffuse toxic goiter. Pretibial myxedema may also occur during the course of nonthyrotoxic thyroid disease. A case of pretibial myxedema with diffuse toxic goiter in 64 year-old female is reported. She has been suffered from thickened yellowish waxy pIaques on both pretibial areas and left dorsum of foot. Initial skin lesions developed about 7 months ago, and increased its size and numbers insidiously. Diagnosis was confirmed by characteristic clinical, laboratory and histopathological findings. Literatures were reviewed.
Diagnosis ; Female ; Foot ; Goiter* ; Humans ; Middle Aged ; Myxedema* ; Skin ; Thyroid Diseases

In 20 patients with psoriasis, 27 early psoriatic lesions of 1-2mm size (16 papules with scale and 11 maculopapules without scale) and 15 clinically uninvolved skin at distance of 2-4em from the nearest psoriatic lesion were histologically examined in an attempt to obtain information on the mechanism which initiates the development of the skin changes. (countinued..)
Humans ; Psoriasis ; Skin

We recently noticed four cases of Vibrio(V.) vulnificus infection from July, 1985 to September, 1985. The V. vulnificus was isolated by culture from the necrotizirig skin bullae in three cases, blood culture in two cases, and cerebrospinal fluid(CSF) in one case. The clinical characteristics of V. vulnificus infection in our cases was as follows: 1)All patients were men with their age over forties and the outbreak of the disease was during the summer season. 2) It was suspected that all patients had the previous hepatic problems. 3) The skin lesions showing bullae in three patients and subcutaneous nodules in one patient were noticed. 4) Two patients were showed positive in blood culture and one of thern also showed positive in lesional skin, urine and CSF. Lesional skin culture showed positive in three patients. 5) The isolated v. ulnificus was sensitive to chloramphenicol, erythromycin, gentamycin, kanamycin and cefobid. 6) Two patients died due to sepsis within 48 hours after liospitalization and one patient died due to hepatic failure.
Cefoperazone ; Chloramphenicol ; Erythromycin ; Gentamicins ; Humans ; Kanamycin ; Liver Failure ; Male ; Seasons ; Sepsis ; Skin ; Vibrio vulnificus* ; Vibrio*

In order to evaluate the effect of zinc sulfate on acne vulgaris, this study was performed during 3 months' period from October, 1979 to December 31, 1979. Total number of acne patients visited at the Department of Dermatology, Han Gang Sung Shim Hospital were 130, but among them 58 patients had completed this atudy. The patients were classified in 3 groups, A, B, C, as follows. Group A (23 patients) who were treated with zinc sulfate (600mg/day) and 2. 5% benzoyl peroxide Group B (20 patients) who were treated with tetracycline (initial: 750mg/day, after 2weeks: 500rng/day) and 2. 5% benzoyl peroxide. Group C (15 patients) who were treated with only 2. 5% benzoyl peroxide. To evaluate the efficacy of treatment in these 3 groups, the number of open comedone, closed comedone, papule and pustule were counted every other week for 8 weeks. (countiuned..)
Acne Vulgaris ; Benzoyl Peroxide ; Dermatology ; Humans ; Tetracycline ; Zinc Sulfate* ; Zinc*

We herein report a case of Spitz nevus which occurred in a 6-year-old girl with acute lymphocytic leukemia. The lesion was a well delimited, symmetric, 1.0 * 1.0cm sized, dome-shaped light pinkish nodule with a shiny surface on her forehead. The histopathological findings of the excisional biopsy specimen revealed mild epidermal hyperplasia ; numerous uniform nests of spindle cells and epitheloid cells with sparce pigmentation along the dermoepidermal junction; colloid body-like eosinophilic globules ; multinucleated giant nevus cells in the epidermis and edema in the upper dermis. Since the complete excision of her lesion was accomplished, there have been no new lesions over the past year.
Biopsy ; Child ; Colloids ; Dermis ; Edema ; Eosinophils ; Epidermis ; Female ; Forehead ; Humans ; Hyperplasia ; Nevus ; Nevus, Epithelioid and Spindle Cell* ; Pigmentation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*

BACKGROUND: Specified clinical observations regarding skin changes in viral hepatitis have not yet been accomplished in Korea, especially in view of serotypes. OBJECTIVE: This study was conducted to identify various cutaneous manifestations of viral hepatitis according to viral serotypes and the stages of the disease. METHODS: We performed a clinical observation of cutaneous manifestations in 450 patients who were diagnosed with viral hepatitis. RESULTS: 1. Cutaneous manifestations were found in 383(85.1%) patients. Patients with a longer duration seemed to have skin lesions more frequently. 2. The frequency of cutaneous manifestations was highest in HAV(94.4%) and HBV(84.9%) serotypes. The most common cutaneous manifestation was pruritus(32.4%) in all studied subjects. In HBV hepatitic patients, the most common cutaneous manifestation was pruritus(35.4%), in HCV hepatitic patients, vasculitic purpura(74.5%), in HAV hepatitic patients, urticaria(88.8%), in the hepatitic patients with the mixed form, spider angioma(30.2%) and vasculitic purpura(30.2%). 3. Urticarial lesions in non-HCV hepatitis were of the lymphocytic vasculitis type but HCV hepatitis was associated with neutrophilic vasculitis. The purpuric lesions with HCV hepatitis were of the neutrophilic vasculitis type while lymphocytic vasculitis was present in non-HCV hepatitis. 4. The most severe pruritus was present in HBV hepatitic patients. CONCLUSION: The cutaneous manifestations in viral hepatitis have different clinical features depending on the viral types.
Hepatitis* ; Humans ; Korea ; Neutrophils ; Pruritus ; Skin ; Spiders ; Vasculitis