No abstract available.
Cardioplegic Solutions* ; Glucose* ; Mannitol* ; Myocardium*

No abstract available.
Cardiopulmonary Bypass* ; Endarterectomy* ; Pulmonary Embolism*

The functional characteristics of Kock continent ileal reservoir were studied in 25 patients who underwent continent ileal reservoir at Seoul National University Hospital from Jan. 1987. Among them 23 patients underwent simultaneous total cystectomy and this procedure for bladder tumor, 2 patients a reservoir procedure only for a neurogenic bladder or urethral stricture. The operating procedure was carried out according to Skinner modification of Kock method initially and according to our minor modification subsequently. The catheterization mode, urine culture, volume and pressure of reservoir were checked by every 3 months. Fluoroscopic examination of reservoir was carried at 3. 6 and 12 months of follow-up. The capacity of reservoir was 200ml just postoperatively, Which increased to 450ml at 3 months, to 750ml at 6 months but did not increased thereafter. Low reservoir pressure without involuntary spike was recognized in most patients except in 2 patients where involuntary spike above 20 cmH20 were noticed in cystometry, but it did not related to incontinence. There were no reflux or true incontinence in followup period by fluoroscopic examination, but in 2 patients partial incontinence occurred when urine volume exceeded 200ml. Various microorganisms were grown in 80% or patients but there were no clinical symptoms. The results indicate that the continent ileal reservoir provide a urine storage function with adequate capacity and without reflux and incontinence. Most patients appreciate better quality of life by not having collecting device.
Catheterization ; Catheters ; Colonic Pouches* ; Cystectomy ; Follow-Up Studies ; Humans ; Quality of Life ; Seoul ; Urethral Stricture ; Urinary Bladder Neoplasms ; Urinary Bladder, Neurogenic

No abstract available.
Staphylococcal Scalded Skin Syndrome*

We studied the effect of retinoic acid, a potent differentiation inducer, on the proliferation and invasiveness of hormone resistant prostatic cancer cell lines, PC-3 and DU-145. Cellular growth measurement by MTY assay, flow cytometry for cell cycle analysis, Papanicolaou staining for examining the change of morphologic features and in vitro invasion assay using artificial basement membrane, matrigel, were performed under various concentration of all-trans-retinoic acid. Inhibition of cellular proliferation was retinoic acid dose dependent in both cell lines. Decreased S-phase and increased G-1 phase fraction were identified with time dependent manner in both cell lines. Less prominent chromatin and nucleotide, decreased nucleus/cytoplasm ratio were shown in Papanicolaou staining after 7 days culture with 10 uM of retinoic acid. In in vitro invasion assay, PC-3 cells showed decreased netlike formation and penetration though matrigel, and DU-145 cells showed decreased colony formation with 10 uM of retinoic acid. These findings suggest that the retinoic acid could ave the possibility of clinical application in hormone resistant prostatic cancer patients as a new therapeutic modality, differentiation therapy.
Basement Membrane ; Cell Cycle ; Cell Line* ; Cell Proliferation ; Chromatin ; Flow Cytometry ; Humans ; Prostatic Neoplasms* ; Tretinoin*

No abstract available.
Pseudomyxoma Peritonei*

No abstract available.
Humans ; Infant* ; Infant, Low Birth Weight* ; Infant, Newborn

Pelvic sarcoma is rare disease. It is very difficult to detect and to treat such tumor in early stage due to the location. But modern anti-cancer therapeutic modalities improve the prognosis. Herein we analyze the experiences of 8 patients of pelvic sarcoma during a recent 10 year period. Six patients were male and 2 were female. Presentations were urinary obstruction in 3 patients, abdominal mass in 5. Various radiologic diagnostic examinations were performed and the results of compressing the adjacent organs rather invasion were founded. Distant metastasis was not recognized in all cases. Exploratory laparotomies were performed in all patients. In 5 patients, mass excision with or without adjacent organs was possible and fecal or urinary diversions were done. In 3 patients, the excision was impossible and fecal, urinary diversions and biopsy for pathologic diagnosis were done. Rhabdomyosarcoma was in one patient, leiomyosarcoma in 3, liposarcoma in 3 and extraskeletal myxoid chondrosarcoma is one. In postoperative long term follow up, the 3 patients died within 6 months whose tumors were not resectable. The 3 patients survived more than 3 years whose tumor masses were excised and who received adjuvant chemotherapy and/or radiotherapy. In one patient, a local recurrence occurred and died of sepsis during postoprative chemotherapy, in one patient now in observation under radiotherapy. The treatment of sarcoma in pelvic cavity must include multiple anti-cancer therapeutic modalities.
Biopsy ; Chemotherapy, Adjuvant ; Chondrosarcoma ; Diagnosis ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Laparotomy ; Leiomyosarcoma ; Liposarcoma ; Male ; Neoplasm Metastasis ; Prognosis ; Radiotherapy ; Rare Diseases ; Recurrence ; Rhabdomyosarcoma ; Sarcoma* ; Sepsis ; Urinary Diversion ; Urology*

An in vitro method using agarose gel which is chemically stable and easily soluble for growing various stones is developed. The optimal conditions for formation of stone crystals in agarose gel were defined as 0.75% of gel concentration, 7ml of gel volume and 24mm of diameter of test tube. We studied the formation and inhibition of calcium oxalate and calcium phosphate crystals which comprises most urinary stones. Calcium containing stones formed under different conditions including pH in this media were identified by qualitative and quantitative analysis and light as well as scanning electron microscopic examination. Calcium oxalate monohydrate(whewellite) was formed in all pH condition, calcium hydro genphosphate dehydrate(brushite) in pH 5.5 and octacalcium phosphate in pH 7.5. The results obtained indicate that agarose gel system is a good model for an investigation of stone crystal formation because of its simplicity and reproducibility. The effects of known inhibitor, magnesium, citrate and pyrophosphate to the formation of calcium oxalate and calcium phosphate crystals were explored in this system. The inhibitory activity of pyrophosphate was maximum, then citrate, magnesium in order, in both calcium oxalate monohydrate and octacalcium phosphate crystal formation and the activity was not influenced by a variation in pH. However the activity of these inhibitors was minimal in calcium hydrogenphosphate dehydrate. According to the findings that the appearance of the crystal was similar, but size of it was smaller in the formed crystals which was under influence of the inhibitors, the inhibitory activity appeared to exerted on the process of crystal aggregation.
Calcium Oxalate* ; Calcium* ; Citric Acid ; Hydrogen-Ion Concentration ; Magnesium ; Sepharose* ; Urinary Calculi ; Urolithiasis

The cytologic examination of voided urine and bladder washings was done in 220 patients with bladder tumors from January, 1986 to June, 1989. Sixty hundred and thirty six specimens including 415 voided urine specimens and 221 bladder washings were examined. Among those, 160 paired specimens of both voided urine and bladder washings were taken from one patient on the same day. Specimens were stained by the Papanicolaou method, and they were interpreted as being negative when the cytologic examination was normal or showed benign atypia and positive when malignant cells were suspected or clearly evident. Sensitivity and specificity of the cytologic examination were 41.8%, 91.9% as a whole, and 34,6%, 96.6% in voided urine and 54.4%, 82.4% in bladder washings. The sensitivity of voided urine and bladder washings was increased as the tumor size, number, grade and stage were increased. A positive urine cytology without a visible tumor in voided urine was seen in 5 cases and the tumor recurred in all 3 patients who were followed up for more than 3 months. Among fifteen cases of a positive cytology without a visible tumor in bladder washings, 9 cases were followed up for more than 3 months, and the tumor recurred in 2 of 9 cases. In conclusion, the voided urine and bladder washings were complementary for the diagnostic accuracy of cytologic examination, and careful follow-up is necessary for a patient with a positive cytology without a visible tumor.
Diagnosis* ; Follow-Up Studies* ; Humans ; Sensitivity and Specificity ; Urinary Bladder Neoplasms* ; Urinary Bladder*