No abstract available.
Cardioplegic Solutions* ; Glucose* ; Mannitol* ; Myocardium*

No abstract available.
Cardiopulmonary Bypass* ; Endarterectomy* ; Pulmonary Embolism*

The functional characteristics of Kock continent ileal reservoir were studied in 25 patients who underwent continent ileal reservoir at Seoul National University Hospital from Jan. 1987. Among them 23 patients underwent simultaneous total cystectomy and this procedure for bladder tumor, 2 patients a reservoir procedure only for a neurogenic bladder or urethral stricture. The operating procedure was carried out according to Skinner modification of Kock method initially and according to our minor modification subsequently. The catheterization mode, urine culture, volume and pressure of reservoir were checked by every 3 months. Fluoroscopic examination of reservoir was carried at 3. 6 and 12 months of follow-up. The capacity of reservoir was 200ml just postoperatively, Which increased to 450ml at 3 months, to 750ml at 6 months but did not increased thereafter. Low reservoir pressure without involuntary spike was recognized in most patients except in 2 patients where involuntary spike above 20 cmH20 were noticed in cystometry, but it did not related to incontinence. There were no reflux or true incontinence in followup period by fluoroscopic examination, but in 2 patients partial incontinence occurred when urine volume exceeded 200ml. Various microorganisms were grown in 80% or patients but there were no clinical symptoms. The results indicate that the continent ileal reservoir provide a urine storage function with adequate capacity and without reflux and incontinence. Most patients appreciate better quality of life by not having collecting device.
Catheterization ; Catheters ; Colonic Pouches* ; Cystectomy ; Follow-Up Studies ; Humans ; Quality of Life ; Seoul ; Urethral Stricture ; Urinary Bladder Neoplasms ; Urinary Bladder, Neurogenic

No abstract available.
Pseudomyxoma Peritonei*

Pelvic sarcoma is rare disease. It is very difficult to detect and to treat such tumor in early stage due to the location. But modern anti-cancer therapeutic modalities improve the prognosis. Herein we analyze the experiences of 8 patients of pelvic sarcoma during a recent 10 year period. Six patients were male and 2 were female. Presentations were urinary obstruction in 3 patients, abdominal mass in 5. Various radiologic diagnostic examinations were performed and the results of compressing the adjacent organs rather invasion were founded. Distant metastasis was not recognized in all cases. Exploratory laparotomies were performed in all patients. In 5 patients, mass excision with or without adjacent organs was possible and fecal or urinary diversions were done. In 3 patients, the excision was impossible and fecal, urinary diversions and biopsy for pathologic diagnosis were done. Rhabdomyosarcoma was in one patient, leiomyosarcoma in 3, liposarcoma in 3 and extraskeletal myxoid chondrosarcoma is one. In postoperative long term follow up, the 3 patients died within 6 months whose tumors were not resectable. The 3 patients survived more than 3 years whose tumor masses were excised and who received adjuvant chemotherapy and/or radiotherapy. In one patient, a local recurrence occurred and died of sepsis during postoprative chemotherapy, in one patient now in observation under radiotherapy. The treatment of sarcoma in pelvic cavity must include multiple anti-cancer therapeutic modalities.
Biopsy ; Chemotherapy, Adjuvant ; Chondrosarcoma ; Diagnosis ; Drug Therapy ; Female ; Follow-Up Studies ; Humans ; Laparotomy ; Leiomyosarcoma ; Liposarcoma ; Male ; Neoplasm Metastasis ; Prognosis ; Radiotherapy ; Rare Diseases ; Recurrence ; Rhabdomyosarcoma ; Sarcoma* ; Sepsis ; Urinary Diversion ; Urology*

We studied the effect of retinoic acid, a potent differentiation inducer, on the proliferation and invasiveness of hormone resistant prostatic cancer cell lines, PC-3 and DU-145. Cellular growth measurement by MTY assay, flow cytometry for cell cycle analysis, Papanicolaou staining for examining the change of morphologic features and in vitro invasion assay using artificial basement membrane, matrigel, were performed under various concentration of all-trans-retinoic acid. Inhibition of cellular proliferation was retinoic acid dose dependent in both cell lines. Decreased S-phase and increased G-1 phase fraction were identified with time dependent manner in both cell lines. Less prominent chromatin and nucleotide, decreased nucleus/cytoplasm ratio were shown in Papanicolaou staining after 7 days culture with 10 uM of retinoic acid. In in vitro invasion assay, PC-3 cells showed decreased netlike formation and penetration though matrigel, and DU-145 cells showed decreased colony formation with 10 uM of retinoic acid. These findings suggest that the retinoic acid could ave the possibility of clinical application in hormone resistant prostatic cancer patients as a new therapeutic modality, differentiation therapy.
Basement Membrane ; Cell Cycle ; Cell Line* ; Cell Proliferation ; Chromatin ; Flow Cytometry ; Humans ; Prostatic Neoplasms* ; Tretinoin*

No abstract available.
Humans ; Infant* ; Infant, Low Birth Weight* ; Infant, Newborn

No abstract available.
Child* ; Humans ; Tuberculosis, Renal*

Assay of serum acid phosphatase activity have become a routine and standard examination for the diagnosis and monitoring of patients with prostatic carcinoma. However its value in these situation has become increasingly controversial. Herein we performed enzymatic assay and radioimmunoassay in 30 normal Korean males, 20 histologically diagnosed B. P. H patients and 15 patients with a histologic diagnosis of prostatic carcinoma. Bodansky method was used in enzymatic assay and its normal range was 0.1 U/dl. In radioimmunoassay the double-antibody method was used. The results of enzymatic assay in normal males were in within normal range. In radioimmunoassay the results were ranged 0.5-3.2ng/ml and the mean was 1. 65+/-0.62 ng/ml. The results of B. P. H. patients were in normal range by both methods. Three of 15 patients with prostatic carcinoma were in stage A or C and their values were within normal range by both methods. Among 12 patients with bony metastatic prostate carcinoma, the valus were elevated in 10 patients by enzymatic away, but were elevated in all patients by radioimmunoassay. There was no significant difference between two methods statistically (p >0.05). The elevated values were found in B. F. H. patients immediately following T. U. R. in 3 patients by radioimmunoassay In 4 patients with bony metastatic prostate carcinoma, the values were decreased following endocrine therapy. Assay of prostatic acid phosphatase are very important in differentiating the tumor stage and in follow-up. Considering a false-positive and false-negative rate, technical problem and cost-effectiveness, the radioimmunoassay is not better than enzymatic assay.
Acid Phosphatase* ; Diagnosis ; Enzyme Assays* ; Follow-Up Studies ; Humans ; Male ; Prostate ; Radioimmunoassay* ; Reference Values

Urothelial tumors of the renal pelvis and ureter are rare. Because of similar histologic appearance, symptomatology and epidemiology both tumors are considered as a single entity. We herein analyze retrospectively 55 patients with urothelial tumors of upper urinary tract who were admitted to Dept. of Urology, Seoul National University Hospital during 15 year period from June, 1970 to June. 1984. Most patients were in 6th and 7th decades. The predominant symptom was hematuria (83 %). The most common finding on I. V. P. was a filling defect (45%), as well as R. G. P.(78 %). The antegrade pyelography and CT scan were beneficial in differential diagnosis of nonopaque filling defect and in differentiating urothelial tumor from renal parenchymal tumor. Concomitant tumors were found in 25% of patients on initial presentation. Various surgical interventions were performed in 45 patients and palliative managements in 10 patients. Major proportion of patients were in stage A. or D. There was close correlation between cellular Grade and tumor Stage. Only 28 patients in 55 were followed properly. 17 patients in 28(61 %) survived more than 2 years. The bladder tumor recurred in 7 in 20 patients with stage A, B or C. Average survival of 8 patients with distant metastasis was 8.6 months. The incidence of bladder tumor in 2 year survived patients was 41%. The recurrence of Ureteral stump were found in 3 of 13 patients(23%).
Diagnosis, Differential ; Epidemiology ; Hematuria ; Humans ; Incidence ; Kidney Pelvis ; Neoplasm Metastasis ; Recurrence ; Retrospective Studies ; Seoul ; Tomography, X-Ray Computed ; Ureter ; Urinary Bladder Neoplasms ; Urinary Tract* ; Urography ; Urology