No abstract available.
Cisplatin* ; Hearing Loss* ; Hearing*

AIM: To study the reactions of human platelet to active complement and the effects of anti-CD59 on human platelet activation induced by complement. METHODS: By applying CVF to activate complement, the platelet aggregation and release reactions induced by activated complement with or without appling anti-CD59 with different doses to block the complement modulative protein CD59 in healthy individuals, were observed. RESULTS: CVF induced platelet release and significant and lasting metamorphosis in healthy individuals, but platelet aggregation was not observed. CVF-induced platelet metamorphosis showed positive linear correlation to lg concentration of CVF (r=0 970. P

No abstract available.
Glycopyrrolate* ; Salivary Glands* ; Scopolamine Hydrobromide*

No abstract available.
Humans

No abstract available.
Laryngectomy* ; Speech, Esophageal*

No abstract available.
Granuloma* ; Intubation*

Rhabdomyolysis is a common clinical and laboratory syndrome resulting from reversible skeletal muscle injury, with release of muscle cell contents into the plasma. Cardioversion, and cardiopulmonary resuscitation may produce rhabdomyolysis and myoglobinuria. We report a 5-year-old boy surviving after cardiopulmonary resuscitation and repeated 5 times of cardioversion. He showed elevated serum BUN and creatinine levels, requiring hemodialysis treatment. We had tried 5 times of intermittent hemodialysis, but oliguria was continued and there was no change of serum BUN and creatinine. His urine output was less than 100 cc per day and he showed severe edema and weight gain of 7 kg, and so we started the continuous renal replacement therapy (Prismaflex(R), gambro). After 12 days of continuous venovenous hemodiafiltration (CVVHDF), his urine output recovered and his BUN, creatinine, liver enzyme, creatine kinase, and lactate dehydrogenase levels returned to normal. During the treatment of CVVHDF, he had shown persistent hypercalcemia, and so we changed dialysate and replacement solution from hemosol B0 to calcium free solution. The hypercalcemia was controlled successfully using this calcium free pharmacy-made bicarbonate solution.
Calcium ; Cardiopulmonary Resuscitation ; Creatine Kinase ; Creatinine ; Edema ; Electric Countershock ; Hemodiafiltration ; Humans ; Hypercalcemia ; L-Lactate Dehydrogenase ; Liver ; Muscle Cells ; Muscle, Skeletal ; Myoglobinuria ; Oliguria ; Plasma ; Preschool Child ; Renal Dialysis ; Renal Replacement Therapy ; Rhabdomyolysis ; Weight Gain

Knowledge about the mechanism and factors that influence olfaction in laryngectomees remains unclear. The aims of this study were to determine the effect of nasal airflow on olfactory ability, as measured by sniff alone and laryngeal bypass with sniff ; to evaluate varying olfactory abilities according to the status of the speech mechanisms in esophageal speakers (ES) and tracheoesophageal shunt speakers (TES) ; and to assess the relationship between speech acceptability and olfactory ability in laryngectomees. Two laryngectomee groups, consisting of ES and TES, and age-matched controls were analyzed through questionnaires, tests applying a Japanese T&T olfactometer to measure thresholds of odor detection and recognition, intravenous alinamin injection tests, and measures of speech acceptability. The findings that laryngeal bypass with sniff and the TES group demonstrated lower olfactory thresholds and shorter latent times than sniff alone and the ES group was informative about the importance of nasal airflow to the olfactory ability in laryngectomees. Furthermore, the close relationship found between olfactory threshold and speech acceptability showed that the ability to transport airflow through the nasal cavity during speech had a strong influence on olfactory ability in laryngectomees.
Asian Continental Ancestry Group ; Humans ; Nasal Cavity ; Odors ; Smell* ; Surveys and Questionnaires

BACKGROUND AND OBJECTIVES: Sudden deafness in the elderly is rare and its prognosis is poorer than in adults. The unaffected ear also may have hearing impairment of variable severity and physiological hearing threshold shift termed presbycusis in the elderly. The old person often had various systemic complications including diabetes and hypertension. This study was designed to evaluate clinical manifestations and prognosis of sudden deafness in the elderly and to compare with sudden deafness in adults and children. SUBJECTS AND METHOD: We reviewed the medical and audiological records of 96 patients (102 ears) who are more than 60 years of age, and admitted to the Department of Otolaryngology, Pusan National University Hospital from January 1990 to December 2001. RESULTS: The total recovery rate of sudden deafness was lower in the elderly than in adults and children. Hearing recovery was significantly poorer in the patients with diabetes and hypertension. Hearing recovery was significantly poor in the patients with profound degree of hearing loss. The patients who had been treated within 7 days after onset of hearing loss showed better recovery rate than those treated 7 days later. CONCLUSION: We consider the effect of treatment of sudden deafness in the elderly to be best judged in various degrees of hearing impairment in the unaffected ear. The poor prognosis observed in patients with the concurrent disease is likely to have been brought about by preexisting microvascular diseases of the hearing organ, which is highly affected by aging. Good hearing recovery in the elderly is considered to be associated with time of initial treatment and expected in patients without concurrent diseases.
Adult ; Aged* ; Aging ; Busan ; Child ; Ear ; Hearing ; Hearing Loss ; Hearing Loss, Sudden* ; Humans ; Hypertension ; Otolaryngology ; Presbycusis ; Prognosis

BACKGROUND AND OBJECTIVES: Raman spectroscopy is a vibrational spectroscopic technique capable of providing details on the chemical composition, molecular structure and molecular interactions in cells and tissues. Its application of distinguishing normal and cancer tissue has been studied in a variety of sites, such as the cervix, lung, larynx and skin. The purpose was to explore spectral changes between normal and cancer tissue in the larynx using Raman spectroscopy to assess the feasibility of using Raman spectroscopy for the early diagnosis of laryngeal cancer. MATERIALS AND METHOD: Laryngeal tissue specimens (13 adjacent normal and 13 cancer tissues) were obtained from patients who underwent total laryngetomy or supracricoid laryngectomy with squamous cell carcinoma of the larynx. The specimens were stored -70 degrees C until use. These specimens were defrosted at room temperature. The Raman spectra from laryngeal tissue specimens could be obtained at 300 mW and 250 scan during 15 minutes of the signal acquisition time using FT-Raman spectroscopy (Bruker Co., Karsruhe, Germany). RESULTS: Raman spectra were different significantly between cancer and adjacent normal tissues of the larynx at 1446 cm-1, 1240 cm-1, 1335 cm-1, and 1655 cm-1 (p=0.007, 0.2, 0.2, 0.3, respectively). The difference of 1446 cm-1 means the change of CH2 bending mode in protein and lipid of malignant tissue. The change of 1335 cm-1 means a decrease in CH3CH2 to a wagging mode of collagen and polynucleotide chain of malignant tissue. The difference of 1240 and 1655 means a decrease in the alpha-helix conformation of collagen. CONCLUSION: This study demonstrates the differences of Raman units between laryngeal cancer and adjacent normal tissue using Raman spectroscopy. In future, Raman spectroscopy may become a useful tool of guided biopsy for accurate pathologic diagnosis and assessment of the adequacy of resection margins.
Biopsy ; Carcinoma, Squamous Cell ; Cervix Uteri ; Collagen ; Diagnosis ; Early Diagnosis ; Female ; Humans ; Laryngeal Neoplasms ; Laryngectomy ; Larynx* ; Lung ; Molecular Structure ; Skin ; Spectrum Analysis ; Spectrum Analysis, Raman*