1.The Tissue Expression of HBsAg and HBcAg in Hepatocellular Carcinoma and Peritumoral Liver.
Jee Young HAN ; Woo Hee JUNG ; Chae Yoon CHON ; Chan Il PARK
Korean Journal of Pathology 1993;27(4):371-378
To evaluate the tissue expression rate and pattenr of HBsAg and HBcAg in tumors and peritumoral livers, an immunohistochemical study was undertaken on 47 surgically resected hepatocellular carcinomas(HCCs). The results are as follows. 1. Patient's sera were positive for HBsAg in 40 cases(85.1%). In the remaining 7 cases, the tumor and peritumoral liver expressed neither HBcAg nor HbSaG, suggesting that they were caused by other etiologies than hepatitis B virus. 2. The peritumoral liver had HBsAg and HBcAg in 95.0% and 27.5% among the 40 cases, respectively. But the tumor expressed HBsAg in 50.0% and HBcAg in none. 3. The expression of HBsAg within the tumor and both HBsAg and HBcAg in the peritumoral liver tended to be more frequent in the pretreated cases before surgery. 4. Edmondson-Steiner grade IV tumors revealed a lower expression rate of HBsAg than the low grade tumors(p<0.05). Incases with cirrhosis at peritumoral tissues, HBcAg was less frequently found than in those without cirrhosis. The majority of tissue HBsAg and HBcAg was represented as groups of positive cells. These results suggest that, during the development and progression of HCCs, the HBcAg containing cells are repeatedly removed and the HBcAg negative cells are selected, because cellular expression of HBcAg is the target of host immune response.
Carcinoma, Hepatocellular
2.Spontaneous left external iliac vein rupture.
Ick Hee KIM ; Gyu Rak CHON ; Yoon Sik JO ; Sung Bae PARK ; Sang Don HAN
Journal of the Korean Surgical Society 2011;81(Suppl 1):S82-S84
We report a 72-year-old female patient with spontaneous rupture of the left external iliac vein. She visited our hospital for abdominal and back pain. She had the abnormal finding of hemoperitoneum. We performed an emergency operation with diagnosis of left ovarian cyst rupture though she suffered from spontaneous rupture of the left external iliac vein. This case provides insight to the experience of spontaneous rupture of the left external iliac vein.
Aged
;
Back Pain
;
Emergencies
;
Female
;
Hemoperitoneum
;
Humans
;
Iliac Vein
;
Ovarian Cysts
;
Rupture
;
Rupture, Spontaneous
3.Design and Implementation of Pulse-Diagnosis Ontology in Ubiquitous Computing Environment.
Dong Il YANG ; Sun Hee PARK ; Ki Hwan CHON
Journal of Korean Society of Medical Informatics 2008;14(1):45-54
OBJECTIVE: This paper proposes an ontology plan for oriental-medical service in ubiquitous computing environment. With popularization of ubiquitous computing technology, recently oriental medicine field becomes interested in oriental medicine knowledge management system and needs more systematic-scientific knowledge management and information communication. But oriental medical scientists have various standards which classify a pulse, so the information about pulse is massive. METHOD: In this paper, for more systematic-scientific knowledge management and information communication, we designed and implemented ontology using the pulse which is used as diagnosis basis in oriental medicine. by using the pulse which is classified into twenty eight division we implemented ontology based on characteristic of each pulse. We represented the pulse with OWL language and used Racer as inference engine to check errors of implemented ontology. RESULT / CONCLUSION: Given the information of the pulse-diagnosis ontology, systematic-scientific knowledge management and information communication become possible so that oriental doctors are able to provide faster and effective medical service. Furthermore, self-diagnosis and medical service will be possible at anytime and anywhere regardless of time and place. In the future research, we will implement an integrated ontology with the whole of diagnosis basis in oriental medicine based on pulse ontology implemented in this paper.
Hypogonadism
;
Knowledge Management
;
Medicine, East Asian Traditional
;
Mitochondrial Diseases
;
Ophthalmoplegia
;
Strigiformes
4.Response: Cardio-Ankle Vascular Index as a Surrogate Marker of Early Atherosclerotic Cardiovascular Disease in Koreans with Type 2 Diabetes Mellitus (Diabetes Metab J 2018;42:285-95).
Diabetes & Metabolism Journal 2018;42(5):449-450
No abstract available.
Biomarkers*
;
Cardiovascular Diseases*
;
Diabetes Mellitus, Type 2*
5.ERCP in the Diagnosis of Peri - vater Diverticula Causing Pancreatobiliary Disease.
Jin Kyung KANG ; Kyung Hee KIM ; Jai Bock JUNG ; Chae Yoon CHON ; Young Myoug MOON ; In Suh PARK ; Heung Jai CHOI
Korean Journal of Gastrointestinal Endoscopy 1984;4(1):40-44
Peri-vater divertieula may interfere with the normal flow of biliary and pancreatic secretion, thus leading to pancreatobiliary diseasa and the very presence of juxtapapillary diverticulum makes cannulation technically difficult and contributes to the low success rate. In this present series, the relationship between duodenal diverticula and age, sex, and biliary-pancreatic pathology was stud.ied in 1400 patients examined with ERCP. The results are as follows. 1) Duodenal diverticula was demonstrated in 73 of 1400 patients(5, 2%). 2) The incidence of duodenal divertieular increased with age and they were more frequent in men. 3) The cannulation of one or both duct system was suecessful in 69 of the 73 patients, the success rate was 94. 5%. 4) The biliary pathology was found in 41 of the 73 patients and the pancreatic pathology in 6 of the 73 patients. The rnost common finding was biliary calculi which were demonstrated in 35 patients(47. 9%).
Catheterization
;
Cholangiopancreatography, Endoscopic Retrograde*
;
Diagnosis*
;
Diverticulum*
;
Gallstones
;
Humans
;
Incidence
;
Male
;
Pathology
6.Assessment of Insulin Secretion and Insulin Resistance in Human
So Young PARK ; Jean-François GAUTIER ; Suk CHON
Diabetes & Metabolism Journal 2021;45(5):641-654
The impaired insulin secretion and increased insulin resistance (or decreased insulin sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is very important to assess the pancreatic β-cell function and insulin resistance/ sensitivity to determine the type of DM and to plan an optimal management and prevention strategy for DM. So far, various methods and indices have been developed to assess the β-cell function and insulin resistance/sensitivity based on static, dynamic test and calculation of their results. In fact, since the metabolism of glucose and insulin is made through a complex process related with various stimuli in several tissues, it is difficult to fully reflect the real physiology. In order to solve the theoretical and practical difficulties, research on new index is still in progress. Also, it is important to select the appropriate method and index for the purpose of use and clinical situation. This review summarized a variety of traditional methods and indices to evaluate pancreatic β-cell function and insulin resistance/sensitivity and introduced novel indices.
7.Assessment of Insulin Secretion and Insulin Resistance in Human
So Young PARK ; Jean-François GAUTIER ; Suk CHON
Diabetes & Metabolism Journal 2021;45(5):641-654
The impaired insulin secretion and increased insulin resistance (or decreased insulin sensitivity) play a major role in the pathogenesis of all types of diabetes mellitus (DM). It is very important to assess the pancreatic β-cell function and insulin resistance/ sensitivity to determine the type of DM and to plan an optimal management and prevention strategy for DM. So far, various methods and indices have been developed to assess the β-cell function and insulin resistance/sensitivity based on static, dynamic test and calculation of their results. In fact, since the metabolism of glucose and insulin is made through a complex process related with various stimuli in several tissues, it is difficult to fully reflect the real physiology. In order to solve the theoretical and practical difficulties, research on new index is still in progress. Also, it is important to select the appropriate method and index for the purpose of use and clinical situation. This review summarized a variety of traditional methods and indices to evaluate pancreatic β-cell function and insulin resistance/sensitivity and introduced novel indices.
8.Perioperative Management and Outcomes in Children with Hereditary Bleeding Disorder: a Retrospective Review at a Single Hemophilia Treatment Center
Ha Nuel CHON ; Ja Hyang CHO ; Young Shil PARK
Clinical Pediatric Hematology-Oncology 2020;27(2):113-119
Background:
Establishing hemostasis for surgical procedures in children with hereditary bleeding disorders is challenging. We evaluated the results of surgical procedures in children with hereditary bleeding disorders at our center and reviewed the preoperative management and hemorrhagic complications.
Methods:
We conducted a retrospective electronic medical record review from October 2006 to September 2019. Children with hereditary bleeding disorders who had elective surgeries or emergency operations were identified by an electronic record search. The primary focus was a review of clotting factor replacement strategies and bleeding complications.
Results:
In total, 126 elective procedures and 4 emergency surgeries were performed on 95 children at our center. Of the 95 children, hemophilia A, hemophilia B, von Willebrand disease, and factor VII deficiency were 74, 15, 4, and 2, respectively. The main disease distribution of procedures was 99 with hemophilia A, 24 with hemophilia B, and 4 with von Willebrand disease. Procedures included various orthopedic surgeries (87/130, 66.9%), placement or revision of a central venous catheter (8/130, 6.2%), and otolaryngology procedures (7/130, 5.4%). All patients received preoperative clotting factor replacement followed by various postoperative clotting factor replacement regimens. Thirteen procedures (10.0%) in five children were performed in the presence of high titers of clotting factor inhibitors. No deaths or life-threatening bleeding occurred after any procedure. Nine of the 130 procedures (6.9%) were complicated by postoperative bleeding. Tonsillectomy and adenoidectomy were the most common procedures complicated by hemorrhage (3/5, 60%).
Conclusion
Surgical procedures are safe in children with hereditary bleeding disorders with adequate preparation and replacement of clotting factors. Bleeding remains a problem in a subset of patients and requires ongoing hematological involvement and oversight. Delayed bleeding following tonsillectomy was particularly common and suggests a need for close follow-up and ongoing factor administration for this group of patients.
9.A Serous Papillary Cystadenoma of Borderline Malignancy in Testis.
Hyun Jun PARK ; Sung Woo PARK ; Won Hee CHON ; Suk Gun JUNG ; Nam Cheol PARK
Korean Journal of Andrology 2007;25(1):36-38
Serous papillary cystadenomas arising in testis have been rarely reported, and they often resemble ovarian serous tumors of borderline malignancy. Herein, we report a case of a serous papillary cystadenoma of the testis in a 59 year old man. Based on a clinical diagnosis of left testicular tumor, a left radical orchiectomy was performed. The pathologic evaluation revealed a serous papillary cystadenoma of borderline malignancy in the testis.
Cystadenoma, Papillary*
;
Diagnosis
;
Humans
;
Middle Aged
;
Orchiectomy
;
Testis*
10.A case of primary hepatic angiosarcoma.
Sang Jin PARK ; Chae Yoon CHON ; Hyun Seung SHIN ; Hee Yong MOON ; Kwang Hyub HAN ; Yung Myung MOON ; Jin Kyung KANG ; In Suh PARK ; Chan Il PARK
Korean Journal of Medicine 1993;45(6):818-823
No abstract available.
Hemangiosarcoma*