1.Intrahepatic cholestasis of pregnancy.
Xiao-Dong WANG ; Mao-Mao HE ; Zheng-Fei LIU
Chinese Journal of Hepatology 2008;16(8):634-636
3.Spontaneous Resolution of Vanishing Bile Duct Syndrome in Hodgkin's Lymphoma.
Woo Sik HAN ; Eun Suk JUNG ; Youn Ho KIM ; Chung Ho KIM ; Sung Chul PARK ; Ji Yeon LEE ; Yun Jung CHANG ; Jong Eun YEON ; Kwan Soo BYUN ; Chang Hong LEE
The Korean Journal of Hepatology 2005;11(2):164-168
Cholestasis in a patient with Hodgkin's disease is uncommon, and the causes of cholestasis are mainly direct tumor involvement of the liver, hepatotoxic effects of drugs, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome (VBDS) represents a very rare cause for cholestasis in this disease. We report here on a case of a 45-year-old man who developed VBDS during the complete remission stage of Hodgkin's lymphoma. There was no history of hepatitis or intravenous drug abuse, and the patient had negative results for hepatitis A virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, and human immunodeficiency virus. The serological studies for antinuclear antibodies, anti-mitochondrial antibodies and anti-smooth muscle antibodies were also negative. Liver biopsy disclosed the absence of interlobular bile ducts in 9 of 10 portal tracts without any active lymphocyte infiltration and there were no Reed-Sternberg cell in the liver. The patient's cholestasis was in remission and the serum bililrubin level was normalized after two months without treatment, but tumor recurrence was noted at multiple sites of the abdominal lymph nodes on follow-up abdomino-pelvic computed tomogram.
Adult
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Bile Duct Diseases/*complications/diagnosis
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*Bile Ducts, Intrahepatic
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Cholestasis/*complications
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English Abstract
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Hodgkin Disease/*complications
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Humans
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Male
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Remission, Spontaneous
5.Intrahepatic cholestasis due to mitochondrial respiratory chain complex I deficiency in a Chinese boy.
Tong-Fei WU ; Yu-Peng LIU ; Qiao WANG ; Xi-Yuan LI ; Yan-Yan MA ; Jin-Qing SONG ; Yan-Ling YANG
Chinese Journal of Contemporary Pediatrics 2012;14(4):241-246
Mitochondrial respiratory chain deficiency is a common cause of mitochondrial disease in children. This study aimed to review the clinical, enzymatic and genetic characteristics of a Chinese boy with progressive intrahepatic cholestasis due to mitochondrial respiratory chain complex I deficiency. The boy developed diarrhea from the age of 13 months, followed by progressive body weight loss, jaundice and weakness. His urine organic acids, blood amino acids and acylcarnitines profiles were normal. Mitochondrial respiratory chain complexes I to V activities in peripheral leukocytes were measured using spectrophotometric assay. Complex I activity was reduced. 5821G>A mutation was indentified by gene sequencing on tRNA-cys of mitochondrial gene in the patient and his mother. Vitamin supplements, liver protection, antibiotics and plasma infusion were not effective in the patient. Unfortunately, the boy died at the age of 17 months. Mitochondrial respiratory chain complex I deficiency is the most common mitochondrial respiratory chain disorder. This was the first case of intrahepatic cholestasis due to complex I deficiency confirmed by mitochondrial respiratory chain enzyme activity assay and gene analysis in China. It was concluded that mitochondrial hepatopathy is one of major causes of metabolic hepatopathy. Biochemical assay, mitochondrial respiratory chain complex activities assay and genetic analysis are crucial for the etiological diagnosis of metabolic hepatopathy.
Cholestasis, Intrahepatic
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diagnosis
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etiology
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Diagnosis, Differential
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Electron Transport Complex I
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deficiency
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Humans
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Infant
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Male
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Mitochondrial Diseases
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complications
6.A Case of Cholestatic Hepatitis Induced by Epstein-Barr Virus Infection.
Min Jae PARK ; In Kwon CHUNG ; Young Dae PARK ; Yun Jin CHUNG ; Ho Chul LEE ; Han Jin CHO ; Eun Hee SEO ; Chang Min CHO ; Won Young TAK ; Sung Kook KIM ; Yong Whan CHOI ; Young Oh KWEON
The Korean Journal of Hepatology 2006;12(2):237-242
Acute viral hepatitis in human can be caused by a large number of viruses with a wide range of clinical manifestations and laboratory findings. EBV is a rare causative agent of an acute hepatitis, during the course of infectious mononucleosis. Hepatic manifestations of EBV are usually mild and resolve without serious complications. EBV is rather uncommonly confirmed as an etiologic agent in acute viral hepatitis of adults and it rarely causes cholestatic hepatitis. We report a case of EBV hepatitis with cholestatic feature that was verified through serum viral marker and liver biopsy.
Male
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Humans
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Hepatitis, Viral, Human/complications/diagnosis/*virology
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Epstein-Barr Virus Infections/complications/*diagnosis
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Cholestasis, Intrahepatic/diagnosis/*virology
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Adult
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Acute Disease
7.A Case of Sustained Cholestasis Caused by Acute A Viral Hepatitis in Dubin-Johnson Syndrome.
Sang Ho RA ; Se Yong SUNG ; Ho Yeon JUNG ; Jae Hwang CHA ; Soon Koo BAIK ; Mee Yon CHO ; Moon Young KIM
The Korean Journal of Gastroenterology 2012;59(4):313-316
Dubin-Johnson syndrome is a rare clinical entity. It shows intermittent symptoms such as chronic or intermittent jaundice, abdominal pain, weakness, nausea, vomiting, anorexia and diarrhea. Symptoms are precipitated or aggravated by pregnancy, alcoholism, surgical procedures and intercurrent disease. Chronic idiopathic jaundice is typical of Dubin-Johnson syndrome and its prognosis is good. We describe a case of prolonged cholestasis for more than 10 months caused by acute A viral hepatitis in a patient with Dubin-Johnson syndrome. It is a first report of cholestasis complicated by acute A viral hepatitis in a patient with Dubin-Johnson syndrome.
Acute Disease
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Adult
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Bilirubin/blood
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Cholangiopancreatography, Endoscopic Retrograde
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Cholestasis/*diagnosis/etiology
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Hepatitis A/complications/*diagnosis
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Humans
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Jaundice, Chronic Idiopathic/complications/*diagnosis
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Liver/pathology
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Male
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Tomography, X-Ray Computed
8.Common Bile Duct Obstruction Due to a Large Stone at the Duodenal Stump.
Jae Kyoung SHIN ; Sung Hoon CHOI ; So Dam HONG ; Saeahm KIM ; Hye Jeong CHO ; Hee Jin HONG ; Hee Kyung KIM ; Kwang Hyun KO
The Korean Journal of Gastroenterology 2016;67(3):150-152
Enterolith is a rare complication of Billroth II gastrectomy. Most enterolith cases have been reported in association with diverticula, tuberculosis, and Crohn's disease. We report the case of a huge enterolith that developed in the duodenal stump following common bile duct obstruction and cholangitis, necessitating surgery. The enterolith was clearly visible on the abdominal computed tomography. It was removed through a duodenotomy. The surgery was successful without any significant complications.
Abdomen/diagnostic imaging
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Aged
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Cholestasis/*diagnosis/etiology/surgery
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Duodenal Diseases/*diagnosis/etiology/surgery
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Female
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Gallstones/complications/diagnosis
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Gastroenterostomy
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Humans
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Tomography, X-Ray Computed
9.Fibrosing Pancreatitis Causing Obstructive Jaundice.
The Korean Journal of Gastroenterology 2008;52(5):271-272
No abstract available.
Child, Preschool
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Cholestasis/diagnosis/etiology
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Drainage
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Female
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Fibrosis
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Humans
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Jaundice, Obstructive/*diagnosis/etiology
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Pancreatitis/complications/*diagnosis/pathology
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Tomography, X-Ray Computed